Detection of neuritic plaques in Alzheimer's disease mouse model

Journal of Visualized Experiments

Volumn , Issue 53, 2011, Pages

  Ly, Philip T T ^a   Cai, Fang ^a   Song, Weihong ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80355132694     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/2831     Document Type: Article

References (4)

1. Glenner, G.G. & Wong, C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 120, 885-890 (1984).
2. Hardy, J. & Selkoe, D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 297, 353-356 (2002).
3. Qing, H., He, G., Ly, P.T., Fox, C.J., Staufenbiel, M., Cai, F., Zhang, Z., Wei, S., Sun, X., Chen, C.H., Zhou, W., Wang, K., & Song, W. Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med. 205, 2781-2789 (2008).
4. Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L.E., & Song, W. Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proc Natl Acad Sci U S A. 103, 18727-18732 (2006).