Development and characterization of pepducins as Gs-biased allosteric agonists

Journal of Biological Chemistry

Volumn 289, Issue 52, 2014, Pages 35668-35684

  Carr, Richard ^a   Du, Yang ^b   Quoyer, Julie ^c   Panettieri, Reynold A ^d   Janz, Jay M ^e,f   Bouvier, Michel ^c   Kobilka, Brian K ^b   Benovic, Jeffrey L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e Anchor Therapeutics   (United States)

^f PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ENZYMES; MUSCLE;

ADRENERGIC RECEPTORS; AIRWAY SMOOTH MUSCLES; G PROTEIN ACTIVATION; G PROTEIN-COUPLED RECEPTOR KINASE; HUMAN AIRWAY SMOOTH MUSCLE CELLS; INTRACELLULAR LOOP; PULMONARY FUNCTION; RECEPTOR INTERACTION;

PROTEINS;

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR ICL3 8 PEPDUCIN; BETA 2 ADRENERGIC RECEPTOR ICL3 9 PEPDUCIN; BETA 2 ADRENERGIC RECEPTOR PEPDUCIN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR KINASE; GA BINDING PROTEIN; ISOPRENALINE; SALBUTAMOL; STIMULATING G PROTEIN; UNCLASSIFIED DRUG; CYCLIC AMP; PEPTIDE FRAGMENT; PEPTIDE LIBRARY; PROTEIN BINDING; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG SCREENING; DRUG SPECIFICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; INTERNALIZATION; LIGAND BINDING; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; ALLOSTERISM; BIOSYNTHESIS; CHEMISTRY; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; PEPTIDE LIBRARY; PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; SECOND MESSENGER;

ADRENERGIC BETA-AGONISTS; ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; CYCLIC AMP; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, ADRENERGIC, BETA-2; SECOND MESSENGER SYSTEMS;

EID: 84919934370     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.618819     Document Type: Article

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