-
1
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
-
Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010;468:839-43.
-
(2010)
Nature
, vol.468
, pp. 839-843
-
-
Ko, M.1
Huang, Y.2
Jankowska, A.M.3
Pape, U.J.4
Tahiliani, M.5
Bandukwala, H.S.6
-
2
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
-
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011;19:17-30.
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
-
3
-
-
84866419591
-
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
-
Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, et al. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012;150:1135-46.
-
(2012)
Cell
, vol.150
, pp. 1135-1146
-
-
Lian, C.G.1
Xu, Y.2
Ceol, C.3
Wu, F.4
Larson, A.5
Dresser, K.6
-
4
-
-
84877080268
-
Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma
-
Gambichler T, Sand M, Skrygan M. Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma. Melanoma Res. 2013;23:218-20.
-
(2013)
Melanoma Res
, vol.23
, pp. 218-220
-
-
Gambichler, T.1
Sand, M.2
Skrygan, M.3
-
5
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009;324:930-5.
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
-
6
-
-
77956189495
-
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
-
Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010;466:1129-33.
-
(2010)
Nature
, vol.466
, pp. 1129-1133
-
-
Ito, S.1
D'alessio, A.C.2
Taranova, O.V.3
Hong, K.4
Sowers, L.C.5
Zhang, Y.6
-
7
-
-
84886860116
-
TET enzymes, TDG and the dynamics of DNA demethylation
-
Kohli RM, Zhang Y. TET enzymes, TDG and the dynamics of DNA demethylation. Nature. 2013;502:472-9.
-
(2013)
Nature
, vol.502
, pp. 472-479
-
-
Kohli, R.M.1
Zhang, Y.2
-
8
-
-
79956323623
-
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
-
Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, et al. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature. 2011;473:398-402.
-
(2011)
Nature
, vol.473
, pp. 398-402
-
-
Ficz, G.1
Branco, M.R.2
Seisenberger, S.3
Santos, F.4
Krueger, F.5
Hore, T.A.6
-
9
-
-
84861221693
-
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution
-
Booth MJ, Branco MR, Ficz G, Oxley D, Krueger F, Reik W, et al. Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science. 2012;336:934-7.
-
(2012)
Science
, vol.336
, pp. 934-937
-
-
Booth, M.J.1
Branco, M.R.2
Ficz, G.3
Oxley, D.4
Krueger, F.5
Reik, W.6
-
10
-
-
84455167621
-
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells
-
Yildirim O, Li R, Hung JH, Chen PB, Dong X, Ee LS, et al. Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell. 2010;147:1498-510.
-
(2010)
Cell
, vol.147
, pp. 1498-1510
-
-
Yildirim, O.1
Li, R.2
Hung, J.H.3
Chen, P.B.4
Dong, X.5
Ee, L.S.6
-
11
-
-
84871563384
-
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
-
Mellén M, Ayata P, Dewell S, Kriaucionis S, Heintz N. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell. 2012;151:1417-30.
-
(2012)
Cell
, vol.151
, pp. 1417-1430
-
-
Mellén, M.1
Ayata, P.2
Dewell, S.3
Kriaucionis, S.4
Heintz, N.5
-
12
-
-
84874771985
-
Dynamic readers for 5-(Hydroxy)methylcytosine and its oxidized derivatives
-
Spruijt CG, Gnerlich F, Smits AH, Pfaffeneder T, Jansen PW, Bauer C, et al. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell. 2013;152:1146-59.
-
(2013)
Cell
, vol.152
, pp. 1146-1159
-
-
Spruijt, C.G.1
Gnerlich, F.2
Smits, A.H.3
Pfaffeneder, T.4
Jansen, P.W.5
Bauer, C.6
-
13
-
-
84877693964
-
Ascorbate induces Ten-eleven translocation (TET) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
-
Minor EM, Court BL, Young JL, Wang G. Ascorbate induces Ten-eleven translocation (TET) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J Biol Chem. 2013;288:13669-74.
-
(2013)
J Biol Chem
, vol.288
, pp. 13669-13674
-
-
Minor, E.M.1
Court, B.L.2
Young, J.L.3
Wang, G.4
-
14
-
-
84884704614
-
Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate
-
Dickson KM, Gustafson CB, Young JI, Züchner S, Wang G. Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate. Biochem Biophys Res Commun. 2013;439:522-7.
-
(2013)
Biochem Biophys Res Commun
, vol.439
, pp. 522-527
-
-
Dickson, K.M.1
Gustafson, C.B.2
Young, J.I.3
Züchner, S.4
Wang, G.5
-
15
-
-
84881476916
-
Vitamin C induces TET-dependent DNA demethylation and a blastocyst-like state in ES cells
-
Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, et al. Vitamin C induces TET-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013;500:222-6.
-
(2013)
Nature
, vol.500
, pp. 222-226
-
-
Blaschke, K.1
Ebata, K.T.2
Karimi, M.M.3
Zepeda-Martínez, J.A.4
Goyal, P.5
Mahapatra, S.6
-
16
-
-
84880344660
-
Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals
-
Yin R, Mao SQ, Zhao B, Chong Z, Yang Y, Zhao C, et al. Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J Am Chem Soc. 2013;135:10396-403.
-
(2013)
J am Chem Soc
, vol.135
, pp. 10396-10403
-
-
Yin, R.1
Mao, S.Q.2
Zhao, B.3
Chong, Z.4
Yang, Y.5
Zhao, C.6
-
17
-
-
84888372386
-
Vitamin C modulates TET1 function during somatic cell reprogramming
-
Chen J, Guo L, Zhang L, Wu H, Yang J, Liu H, et al. Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet. 2013;45:1504-9.
-
(2013)
Nat Genet
, vol.45
, pp. 1504-1509
-
-
Chen, J.1
Guo, L.2
Zhang, L.3
Wu, H.4
Yang, J.5
Liu, H.6
-
18
-
-
0030983467
-
Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells
-
Spielholz C, Golde DW, Houghton AN, Nualart F, Vera JC. Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells. Cancer Res. 1997;57:2529-37.
-
(1997)
Cancer Res
, vol.57
, pp. 2529-2537
-
-
Spielholz, C.1
Golde, D.W.2
Houghton, A.N.3
Nualart, F.4
Vera, J.C.5
-
19
-
-
79956072230
-
Vitamin C: A concentration-function approach yields pharmacology and therapeutic discoveries
-
Levine M, Padayatty SJ, Espey MG. Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. Adv Nutr. 2011;2:78-88.
-
(2011)
Adv Nutr
, vol.2
, pp. 78-88
-
-
Levine, M.1
Padayatty, S.J.2
Espey, M.G.3
-
20
-
-
84866613772
-
Ascorbic acid: Chemistry, biology and the treatment of cancer
-
Du J, Cullen JJ, Buettner GR. Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta. 2012;1826:443-57.
-
(2012)
Biochim Biophys Acta
, vol.1826
, pp. 443-457
-
-
Du, J.1
Cullen, J.J.2
Buettner, G.R.3
-
21
-
-
84875537133
-
Epigenetic reprogramming in cancer
-
Suvà ML, Riggi N, Bernstein BE. Epigenetic reprogramming in cancer. Science. 2013;339:1567-70.
-
(2013)
Science
, vol.339
, pp. 1567-1570
-
-
Suvà, M.L.1
Riggi, N.2
Bernstein, B.E.3
-
22
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18:553-67.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
-
23
-
-
84866908544
-
TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases
-
Hsu CH, Peng KL, Kang ML, Chen YR, Yang YC, Tsai CH, et al. TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases. Cell Rep. 2012;2:568-79.
-
(2012)
Cell Rep
, vol.2
, pp. 568-579
-
-
Hsu, C.H.1
Peng, K.L.2
Kang, M.L.3
Chen, Y.R.4
Yang, Y.C.5
Tsai, C.H.6
-
24
-
-
70350686382
-
Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES)
-
Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutr. 2009;90:1252-63.
-
(2009)
Am J Clin Nutr
, vol.90
, pp. 1252-1263
-
-
Schleicher, R.L.1
Carroll, M.D.2
Ford, E.S.3
Lacher, D.A.4
-
25
-
-
77955500681
-
Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (Vitamin C): Evidence from 5 independent studies with >15,000 participants
-
Timpson NJ, Forouhi NG, Brion MJ, Harbord RM, Cook DG, Johnson P, et al. Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. Am J Clin Nutr. 2010;92:375-82.
-
(2010)
Am J Clin Nutr
, vol.92
, pp. 375-382
-
-
Timpson, N.J.1
Forouhi, N.G.2
Brion, M.J.3
Harbord, R.M.4
Cook, D.G.5
Johnson, P.6
-
26
-
-
0035814732
-
New insights into the physiology and pharmacology of vitamin C
-
Padayatty SJ, Levine M. New insights into the physiology and pharmacology of vitamin C. CMAJ. 2001;164:353-5.
-
(2001)
CMAJ
, vol.164
, pp. 353-355
-
-
Padayatty, S.J.1
Levine, M.2
-
27
-
-
84873086305
-
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
-
Harbour JW, Roberson ED, Anbunathan H, Onken MD, Worley LA, Bowcock AM. Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma. Nat Genet. 2013;45:133-5.
-
(2013)
Nat Genet
, vol.45
, pp. 133-135
-
-
Harbour, J.W.1
Roberson, E.D.2
Anbunathan, H.3
Onken, M.D.4
Worley, L.A.5
Bowcock, A.M.6
-
28
-
-
84555171449
-
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1gene in chronic lymphocytic leukemia
-
Quesada V, Conde L, Villamor N, Ordóñez GR, Jares P, Bassaganyas L, et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1gene in chronic lymphocytic leukemia. Nat Genet. 2011;44:47-52.
-
(2011)
Nat Genet
, vol.44
, pp. 47-52
-
-
Quesada, V.1
Conde, L.2
Villamor, N.3
Ordóñez, G.R.4
Jares, P.5
Bassaganyas, L.6
-
29
-
-
84855541345
-
Ascorbate depletion increases growth and metastasis of melanoma cells in vitamin C deficient mice
-
Cha J, Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M. Ascorbate depletion increases growth and metastasis of melanoma cells in vitamin C deficient mice. Exp Oncol. 2011;33:226-30.
-
(2011)
Exp Oncol
, vol.33
, pp. 226-230
-
-
Cha, J.1
Roomi, M.W.2
Ivanov, V.3
Kalinovsky, T.4
Niedzwiecki, A.5
Rath, M.6
-
30
-
-
84873683033
-
Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4 T1 breast cancer cells in vitamin C-deficient mice
-
Cha J, Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M. Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4 T1 breast cancer cells in vitamin C-deficient mice. Int J Oncol. 2013;42:55-64.
-
(2013)
Int J Oncol
, vol.42
, pp. 55-64
-
-
Cha, J.1
Roomi, M.W.2
Ivanov, V.3
Kalinovsky, T.4
Niedzwiecki, A.5
Rath, M.6
-
31
-
-
79956292024
-
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
-
Wu H, D'Alessio AC, Ito S, Xia K, Wang Z, Cui K, et al. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature. 2011;473:389-93.
-
(2011)
Nature
, vol.473
, pp. 389-393
-
-
Wu, H.1
D'alessio, A.C.2
Ito, S.3
Xia, K.4
Wang, Z.5
Cui, K.6
-
32
-
-
84907334161
-
ArhGAP30 promotes p53 acetylation and function in colorectal cancer
-
Wang J, Qian J, Hu Y, Kong X, Chen H, Shi Q, et al. ArhGAP30 promotes p53 acetylation and function in colorectal cancer. Nat Commun. 2014;5:4735.
-
(2014)
Nat Commun
, vol.5
, pp. 4735
-
-
Wang, J.1
Qian, J.2
Hu, Y.3
Kong, X.4
Chen, H.5
Shi, Q.6
-
33
-
-
84876463939
-
Breathing-in epigenetic change with vitamin C
-
Monfort A, Wutz A. Breathing-in epigenetic change with vitamin C. EMBO Rep. 2013;14:337-46.
-
(2013)
EMBO Rep
, vol.14
, pp. 337-346
-
-
Monfort, A.1
Wutz, A.2
-
34
-
-
84906279217
-
Epigenetic impacts of ascorbate on human metastatic melanoma cells
-
Venturelli S, Sinnberg TW, Berger A, Noor S, Levesque MP, Böcker A, et al. Epigenetic impacts of ascorbate on human metastatic melanoma cells. Front Oncol. 2014;4:227.
-
(2014)
Front Oncol
, vol.4
, pp. 227
-
-
Venturelli, S.1
Sinnberg, T.W.2
Berger, A.3
Noor, S.4
Levesque, M.P.5
Böcker, A.6
-
35
-
-
84894593503
-
The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines
-
Sinnberg T, Noor S, Venturelli S, Berger A, Schuler P, Garbe C, et al. The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines. J Cell Mol Med. 2014;18:530-41.
-
(2014)
J Cell Mol Med
, vol.18
, pp. 530-541
-
-
Sinnberg, T.1
Noor, S.2
Venturelli, S.3
Berger, A.4
Schuler, P.5
Garbe, C.6
-
36
-
-
27644490306
-
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression
-
Balint K, Xiao M, Pinnix CC, Soma A, Veres I, Juhasz I, et al. Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest. 2005;115:3166-76.
-
(2005)
J Clin Invest
, vol.115
, pp. 3166-3176
-
-
Balint, K.1
Xiao, M.2
Pinnix, C.C.3
Soma, A.4
Veres, I.5
Juhasz, I.6
-
37
-
-
84871809302
-
STAR: Ultrafast universal RNA-seq aligner
-
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29:15-21.
-
(2013)
Bioinformatics
, vol.29
, pp. 15-21
-
-
Dobin, A.1
Davis, C.A.2
Schlesinger, F.3
Drenkow, J.4
Zaleski, C.5
Jha, S.6
-
38
-
-
84928987900
-
HTSeq — A Python framework to work with high-throughput sequencing data
-
Anders S, Pyl PT, Huber W. HTSeq — A Python framework to work with high-throughput sequencing data. Bioinformatics. 2015;31:166-9.
-
(2015)
Bioinformatics
, vol.31
, pp. 166-169
-
-
Anders, S.1
Pyl, P.T.2
Huber, W.3
-
39
-
-
75249087100
-
EdgeR: A Bioconductor package for differential expression analysis of digital gene expression data
-
Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139-40.
-
(2010)
Bioinformatics
, vol.26
, pp. 139-140
-
-
Robinson, M.D.1
McCarthy, D.J.2
Smyth, G.K.3
-
40
-
-
77958471357
-
Differential expression analysis for sequence count data
-
Anders S, Huber W. Differential expression analysis for sequence count data. Genome Biol. 2010;11:R106.
-
(2010)
Genome Biol
, vol.11
, pp. 106
-
-
Anders, S.1
Huber, W.2
-
41
-
-
77955298482
-
BaySeq: Empirical Bayesian methods for identifying differential expression in sequence count data
-
Hardcastle TJ, Kelly KA. baySeq: empirical Bayesian methods for identifying differential expression in sequence count data. BMC Bioinformatics. 2010;11:422.
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 422
-
-
Hardcastle, T.J.1
Kelly, K.A.2
-
42
-
-
24044440971
-
BiNGO: A Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks
-
Maere S, Heymans K, Kuiper M. BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics. 2005;21:3448-9.
-
(2005)
Bioinformatics
, vol.21
, pp. 3448-3449
-
-
Maere, S.1
Heymans, K.2
Kuiper, M.3
|