-
1
-
-
84866065842
-
How p53 wields the scales of fate: Arrest or death?
-
Goh, A. M. & Lane, D. P. How p53 wields the scales of fate: arrest or death? Transcription 3, 240-244 (2012).
-
(2012)
Transcription
, vol.3
, pp. 240-244
-
-
Goh, A.M.1
Lane, D.P.2
-
2
-
-
84903313705
-
Functions of TAp63 and p53 in restraining the development of metastatic cancer
-
Tan, E. H. et al. Functions of TAp63 and p53 in restraining the development of metastatic cancer. Oncogene 33, 3325-3333 (2014).
-
(2014)
Oncogene
, vol.33
, pp. 3325-3333
-
-
Tan, E.H.1
-
3
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
Maddocks, O. D. et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493, 542-546 (2013).
-
(2013)
Nature
, vol.493
, pp. 542-546
-
-
Maddocks, O.D.1
-
4
-
-
84876291823
-
Non-cell-autonomous tumor suppression by p53
-
Lujambio, A. et al. Non-cell-autonomous tumor suppression by p53. Cell 153, 449-460 (2013).
-
(2013)
Cell
, vol.153
, pp. 449-460
-
-
Lujambio, A.1
-
5
-
-
84862636275
-
Mutant p53: One name, many proteins
-
Freed-Pastor, W. A. & Prives, C. Mutant p53: one name, many proteins. Genes Dev. 26, 1268-1286 (2012).
-
(2012)
Genes Dev.
, vol.26
, pp. 1268-1286
-
-
Freed-Pastor, W.A.1
Prives, C.2
-
6
-
-
84887430076
-
Metabolic regulation by p53 family members
-
Berkers, C. R., Maddocks, O. D., Cheung, E. C., Mor, I. & Vousden, K. H. Metabolic regulation by p53 family members. Cell. Metab. 18, 617-633 (2013).
-
(2013)
Cell. Metab.
, vol.18
, pp. 617-633
-
-
Berkers, C.R.1
Maddocks, O.D.2
Cheung, E.C.3
Mor, I.4
Vousden, K.H.5
-
7
-
-
84873678601
-
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
-
Jiang, P., Du, W., Mancuso, A., Wellen, K. E. & Yang, X. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493, 689-693 (2013).
-
(2013)
Nature
, vol.493
, pp. 689-693
-
-
Jiang, P.1
Du, W.2
Mancuso, A.3
Wellen, K.E.4
Yang, X.5
-
8
-
-
69349100179
-
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
-
Hong, H. et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460, 1132-1135 (2009).
-
(2009)
Nature
, vol.460
, pp. 1132-1135
-
-
Hong, H.1
-
9
-
-
84882281048
-
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint
-
Swaminathan, S. et al. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat. Med. 19, 1014-1022 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 1014-1022
-
-
Swaminathan, S.1
-
10
-
-
84874044758
-
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis
-
Follis, A. V. et al. PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat. Chem. Biol. 9, 163-168 (2013).
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 163-168
-
-
Follis, A.V.1
-
11
-
-
84862675016
-
P53 opens the mitochondrial permeability transition pore to trigger necrosis
-
Vaseva, A. V. et al. p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell 149, 1536-1548 (2012).
-
(2012)
Cell
, vol.149
, pp. 1536-1548
-
-
Vaseva, A.V.1
-
12
-
-
84862270480
-
P53 dynamics control cell fate
-
Purvis, J. E. et al. p53 dynamics control cell fate. Science 336, 1440-1444 (2012).
-
(2012)
Science
, vol.336
, pp. 1440-1444
-
-
Purvis, J.E.1
-
13
-
-
84883634636
-
P53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer
-
Marcel, V. et al. p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer. Cancer Cell 24, 318-330 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 318-330
-
-
Marcel, V.1
-
14
-
-
84877311822
-
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
-
Kenzelmann Broz, D. et al. Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev. 27, 1016-1031 (2013).
-
(2013)
Genes Dev.
, vol.27
, pp. 1016-1031
-
-
Kenzelmann Broz, D.1
-
16
-
-
84888388753
-
The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria
-
Matissek, K. J., Mossalam, M., Okal, A. & Lim, C. S. The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria. Mol. Pharm. 10, 3592-3602 (2013).
-
(2013)
Mol. Pharm.
, vol.10
, pp. 3592-3602
-
-
Matissek, K.J.1
Mossalam, M.2
Okal, A.3
Lim, C.S.4
-
17
-
-
0038269028
-
The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREBbinding protein
-
Liu, G., Xia, T. & Chen, X. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREBbinding protein. J. Biol. Chem. 278, 17557-17565 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17557-17565
-
-
Liu, G.1
Xia, T.2
Chen, X.3
-
18
-
-
0032568539
-
Identification of an additional negative regulatory region for p53 sequence-specific DNA binding
-
Muller-Tiemann, B. F., Halazonetis, T. D. & Elting, J. J. Identification of an additional negative regulatory region for p53 sequence-specific DNA binding. Proc. Natl Acad. Sci. USA 95, 6079-6084 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 6079-6084
-
-
Muller-Tiemann, B.F.1
Halazonetis, T.D.2
Elting, J.J.3
-
19
-
-
0036784608
-
Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein
-
McKinney, K. & Prives, C. Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein. Mol. Cell Biol. 22, 6797-6808 (2002).
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 6797-6808
-
-
McKinney, K.1
Prives, C.2
-
20
-
-
22544484456
-
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
-
Krummel, K. A., Lee, C. J., Toledo, F. & Wahl, G. M. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc. Natl Acad. Sci. USA 102, 10188-10193 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 10188-10193
-
-
Krummel, K.A.1
Lee, C.J.2
Toledo, F.3
Wahl, G.M.4
-
21
-
-
20744448187
-
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
-
Feng, L., Lin, T., Uranishi, H., Gu, W. & Xu, Y. Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol. Cell Biol. 25, 5389-5395 (2005).
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 5389-5395
-
-
Feng, L.1
Lin, T.2
Uranishi, H.3
Gu, W.4
Xu, Y.5
-
22
-
-
84879794532
-
Mutant mice lacking the p53 C-terminal domain model telomere syndromes
-
Simeonova, I. et al. Mutant mice lacking the p53 C-terminal domain model telomere syndromes. Cell Rep. 3, 2046-2058 (2013).
-
(2013)
Cell Rep.
, vol.3
, pp. 2046-2058
-
-
Simeonova, I.1
-
23
-
-
0034862475
-
The C-terminus of p53: The more you learn the less you know
-
Ahn, J. & Prives, C. The C-terminus of p53: the more you learn the less you know. Nat. Struct. Biol. 8, 730-732 (2001).
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 730-732
-
-
Ahn, J.1
Prives, C.2
-
24
-
-
34047103990
-
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
-
Carter, S., Bischof, O., Dejean, A. & Vousden, K. H. C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat. Cell Biol. 9, 428-435 (2007).
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 428-435
-
-
Carter, S.1
Bischof, O.2
Dejean, A.3
Vousden, K.H.4
-
25
-
-
84864677524
-
MDM4 is a key therapeutic target in cutaneous melanoma
-
Gembarska, A. et al. MDM4 is a key therapeutic target in cutaneous melanoma. Nat. Med. 18, 1239-1247 (2012).
-
(2012)
Nat. Med.
, vol.18
, pp. 1239-1247
-
-
Gembarska, A.1
-
26
-
-
84880753919
-
Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network
-
Daftuar, L., Zhu, Y., Jacq, X. & Prives, C. Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network. PLoS ONE 8, e68667 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Daftuar, L.1
Zhu, Y.2
Jacq, X.3
Prives, C.4
-
27
-
-
84873055344
-
MDM2, MDMX and p53 in oncogenesis and cancer therapy
-
Wade, M., Li, Y. C. & Wahl, G. M. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat. Rev. Cancer 13, 83-96 (2013).
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 83-96
-
-
Wade, M.1
Li, Y.C.2
Wahl, G.M.3
-
28
-
-
84877826693
-
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP
-
Lu, M. et al. Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer Cell 23, 618-633 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 618-633
-
-
Lu, M.1
-
29
-
-
84887074375
-
MDMX contains an autoinhibitory sequence element
-
Bista, M., Petrovich, M. & Fersht, A. R. MDMX contains an autoinhibitory sequence element. Proc. Natl Acad. Sci. USA 110, 17814-17819 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 17814-17819
-
-
Bista, M.1
Petrovich, M.2
Fersht, A.R.3
-
30
-
-
43049163953
-
Acetylation is indispensable for p53 activation
-
Tang, Y., Zhao, W., Chen, Y., Zhao, Y. & Gu, W. Acetylation is indispensable for p53 activation. Cell 133, 612-626 (2008).
-
(2008)
Cell
, vol.133
, pp. 612-626
-
-
Tang, Y.1
Zhao, W.2
Chen, Y.3
Zhao, Y.4
Gu, W.5
-
31
-
-
66449099052
-
P53 acetylation is crucial for its transcription-independent proapoptotic functions
-
Yamaguchi, H. et al. p53 acetylation is crucial for its transcription-independent proapoptotic functions. J. Biol. Chem. 284, 11171-11183 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 11171-11183
-
-
Yamaguchi, H.1
-
32
-
-
84872594782
-
P53 acetylation enhances Taxol-induced apoptosis in human cancer cells
-
Kim, J. H. et al. p53 acetylation enhances Taxol-induced apoptosis in human cancer cells. Apoptosis 18, 110-120 (2013).
-
(2013)
Apoptosis
, vol.18
, pp. 110-120
-
-
Kim, J.H.1
-
33
-
-
84881515385
-
The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway
-
de Conti, A. et al. The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway. Carcinogenesis 34, 1900-1906 (2013).
-
(2013)
Carcinogenesis
, vol.34
, pp. 1900-1906
-
-
De Conti, A.1
-
34
-
-
84886743570
-
Lysine-specific modifications of p53: A matter of life and death?
-
Marouco, D., Garabadgiu, A. V., Melino, G. & Barlev, N. A. Lysine-specific modifications of p53: a matter of life and death? Oncotarget 4, 1556-1571 (2013).
-
(2013)
Oncotarget
, vol.4
, pp. 1556-1571
-
-
Marouco, D.1
Garabadgiu, A.V.2
Melino, G.3
Barlev, N.A.4
-
35
-
-
84876459162
-
Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2
-
van Leeuwen, I. M. et al. Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2. Mol. Cancer Ther. 12, 471-480 (2013).
-
(2013)
Mol. Cancer Ther.
, vol.12
, pp. 471-480
-
-
Van Leeuwen, I.M.1
-
36
-
-
84874594177
-
MOZ increases p53 acetylation and premature senescence through its complex formation with PML
-
Rokudai, S. et al. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc. Natl Acad. Sci. USA 110, 3895-3900 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 3895-3900
-
-
Rokudai, S.1
-
37
-
-
84858047563
-
The WTX tumor suppressor enhances p53 acetylation by CBP/p300
-
Kim, W. J., Rivera, M. N., Coffman, E. J. & Haber, D. A. The WTX tumor suppressor enhances p53 acetylation by CBP/p300. Mol. Cell 45, 587-597 (2012).
-
(2012)
Mol. Cell
, vol.45
, pp. 587-597
-
-
Kim, W.J.1
Rivera, M.N.2
Coffman, E.J.3
Haber, D.A.4
-
38
-
-
79952742986
-
RNA content in the nucleolus alters p53 acetylation via MYBBP1A
-
Kuroda, T. et al. RNA content in the nucleolus alters p53 acetylation via MYBBP1A. EMBO J. 30, 1054-1066 (2011).
-
(2011)
EMBO J.
, vol.30
, pp. 1054-1066
-
-
Kuroda, T.1
-
39
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Ferlay, J. et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 127, 2893-2917 (2010).
-
(2010)
Int. J. Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
-
40
-
-
79956193597
-
ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion
-
Naji, L., Pacholsky, D. & Aspenstrom, P. ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. Biochem. Biophys. Res. Commun. 409, 96-102 (2011).
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.409
, pp. 96-102
-
-
Naji, L.1
Pacholsky, D.2
Aspenstrom, P.3
-
41
-
-
84867019805
-
ColoGuideEx: A robust gene classifier specific for stage II colorectal cancer prognosis
-
Agesen, T. H. et al. ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis. Gut 61, 1560-1567 (2012).
-
(2012)
Gut
, vol.61
, pp. 1560-1567
-
-
Agesen, T.H.1
-
42
-
-
84883474258
-
Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells
-
Menendez, D. et al. Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells. Nucleic Acids Res. 41, 7286-7301 (2013).
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 7286-7301
-
-
Menendez, D.1
-
43
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas, N.
-
Cancer Genome Atlas, N. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
-
44
-
-
77950517628
-
BRD7 is a candidate tumour suppressor gene required for p53 function
-
Drost, J. et al. BRD7 is a candidate tumour suppressor gene required for p53 function. Nat. Cell Biol. 12, 380-389 (2010).
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 380-389
-
-
Drost, J.1
-
45
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu, W. & Roeder, R. G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606 (1997).
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
46
-
-
0032490855
-
Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome
-
Davison, T. S., Yin, P., Nie, E., Kay, C. & Arrowsmith, C. H. Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome. Oncogene 17, 651-656 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 651-656
-
-
Davison, T.S.1
Yin, P.2
Nie, E.3
Kay, C.4
Arrowsmith, C.H.5
-
47
-
-
84878603920
-
RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain
-
Xu, J. et al. RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain. Cell Rep. 3, 1526-1538 (2013).
-
(2013)
Cell Rep.
, vol.3
, pp. 1526-1538
-
-
Xu, J.1
-
48
-
-
0042622245
-
Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN
-
Farre, D. et al. Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res. 31, 3651-3653 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 3651-3653
-
-
Farre, D.1
-
49
-
-
84898048775
-
The APC network regulates the removal of mutated cells from colonic crypts
-
Song, J. H. et al. The APC network regulates the removal of mutated cells from colonic crypts. Cell Rep. 7, 94-103 (2014).
-
(2014)
Cell Rep.
, vol.7
, pp. 94-103
-
-
Song, J.H.1
-
50
-
-
84863047242
-
Orphan nuclear receptor PNR/NR2E3 stimulates p53 functions by enhancing p53 acetylation
-
Wen, Z. et al. Orphan nuclear receptor PNR/NR2E3 stimulates p53 functions by enhancing p53 acetylation. Mol. Cell Biol. 32, 26-35 (2012).
-
(2012)
Mol. Cell Biol.
, vol.32
, pp. 26-35
-
-
Wen, Z.1
-
51
-
-
84872354372
-
Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation
-
Wu, D., Ozaki, T., Yoshihara, Y., Kubo, N. & Nakagawara, A. Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation. J. Biol. Chem. 288, 1353-1364 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 1353-1364
-
-
Wu, D.1
Ozaki, T.2
Yoshihara, Y.3
Kubo, N.4
Nakagawara, A.5
-
52
-
-
84890459245
-
Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness
-
Kong, X. et al. Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. J. Natl Cancer. Inst. 105, 1738-1749 (2013).
-
(2013)
J. Natl Cancer. Inst.
, vol.105
, pp. 1738-1749
-
-
Kong, X.1
-
53
-
-
61449172037
-
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
-
Huang da, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57 (2009).
-
(2009)
Nat. Protoc.
, vol.4
, pp. 44-57
-
-
Da Huang, W.1
Sherman, B.T.2
Lempicki, R.A.3
-
54
-
-
55549097836
-
Mapping short DNA sequencing reads and calling variants using mapping quality scores
-
Li, H., Ruan, J. & Durbin, R. Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res. 18, 1851-1858 (2008).
-
(2008)
Genome Res.
, vol.18
, pp. 1851-1858
-
-
Li, H.1
Ruan, J.2
Durbin, R.3
-
55
-
-
50849090969
-
Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data
-
Valouev, A. et al. Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data. Nat. Methods 5, 829-834 (2008).
-
(2008)
Nat. Methods
, vol.5
, pp. 829-834
-
-
Valouev, A.1
-
56
-
-
77951947707
-
ChIPpeakAnno: A Bioconductor package to annotate ChIP-seq and ChIP-chip data
-
Zhu, L. J. et al. ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data. BMC Bioinformatics 11, 237 (2010).
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 237
-
-
Zhu, L.J.1
|