Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury

Neuroscience

Volumn 284, Issue , 2015, Pages 202-216

  Kemp, S W P ^a,b   Szynkaruk, M ^a   Stanoulis, K N ^a   Wood, M D ^a,b   Liu, E H ^a   Willand, M P ^a,b   Morlock, L ^d   Naidoo, J ^d   Williams, N S ^d   Ready, J M ^d   Mangano, T J ^f   Beggs, S ^b   Salter, M W ^b   Gordon, T ^a,b   Pieper, A A ^e,f   Borschel, G H ^a,b,c,f  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Functional recovery; Microglia; Neonatal nerve injury; Neuroprotection; P7C3

Indexed keywords

IONOTROPIC RECEPTOR; NEUROPROTECTIVE AGENT; P 7C 3; P 7C 3 S 184; UNCLASSIFIED DRUG; CARBAZOLE DERIVATIVE; P7C3 COMPOUND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BLOOD BRAIN BARRIER; CELL DEATH; CELL MATURATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG TISSUE LEVEL; FUNCTIONAL ASSESSMENT; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LOCOMOTION; MICROGLIA; MOTONEURON; MOTOR PERFORMANCE; MUSCLE FUNCTION; MUSCLE MASS; MUSCLE REINNERVATION; MUSCLE STRENGTH; NEONATAL NERVE INJURY; NERVE CELL; NERVE FIBER REGENERATION; NERVE INJURY; NEUROPROTECTION; NEWBORN DISEASE; NONHUMAN; PERIPHERAL NERVE INJURY; RAT; SCIATIC NERVE; SENSORIMOTOR FUNCTION; SPINAL GANGLION; TANDEM MASS SPECTROMETRY; ANIMAL; CELL PROLIFERATION; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; LEWIS RAT; MALE; MOVEMENT DISORDERS; NERVE REGENERATION; NEWBORN; PATHOLOGY; SCIATIC NEUROPATHY; SENSATION; SENSORY NERVE CELL; SPINAL CORD;

ANIMALS; ANIMALS, NEWBORN; CARBAZOLES; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; MALE; MICROGLIA; MOTOR NEURONS; MOVEMENT DISORDERS; MUSCLE STRENGTH; NERVE REGENERATION; NEUROPROTECTIVE AGENTS; PERIPHERAL NERVE INJURIES; RATS; RATS, INBRED LEW; SCIATIC NEUROPATHY; SENSATION; SENSORY RECEPTOR CELLS; SPINAL CORD;

EID: 84908389399     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.10.005     Document Type: Article

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