메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; CYTOKINE; ENZYME INHIBITOR; F671-0003; FLUORESCENT DYE; M049-0244; MOLECULAR LIBRARY; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, HUMAN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, MOUSE; QUINOXALINE DERIVATIVE;

EID: 84938544861     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12657     Document Type: Article
Times cited : (25)

References (31)
  • 2
    • 84864269536 scopus 로고    scopus 로고
    • Visfatin/NAMPT: A multifaceted molecule with diverse roles in physiology and pathophysiology
    • Dahl, T. B., Holm, S., Aukrust, P. & Halvorsen, B. Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology. Annu. Rev. Nutr. 32, 229-243 (2012).
    • (2012) Annu. Rev. Nutr. , vol.32 , pp. 229-243
    • Dahl, T.B.1    Holm, S.2    Aukrust, P.3    Halvorsen, B.4
  • 4
    • 84872763359 scopus 로고    scopus 로고
    • Visfatin affects redox adaptative responses and proliferation in Me45 human malignant melanoma cells: An in vitro study
    • Buldak, R. J. et al. Visfatin affects redox adaptative responses and proliferation in Me45 human malignant melanoma cells: an in vitro study. Oncol. Rep. 29, 771-778 (2013).
    • (2013) Oncol. Rep. , vol.29 , pp. 771-778
    • Buldak, R.J.1
  • 5
    • 82355183529 scopus 로고    scopus 로고
    • Introduction: Adipokines and cardiovascular disease
    • Miao, C. Y. Introduction: Adipokines and cardiovascular disease. Clin. Exp. Pharmacol. Physiol. 38, 860-863 (2011).
    • (2011) Clin. Exp. Pharmacol. Physiol. , vol.38 , pp. 860-863
    • Miao, C.Y.1
  • 6
    • 84881367747 scopus 로고    scopus 로고
    • Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
    • Galli, U. et al. Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. J. Med. Chem. 56, 6279-6296 (2013).
    • (2013) J. Med. Chem. , vol.56 , pp. 6279-6296
    • Galli, U.1
  • 7
    • 14844291424 scopus 로고    scopus 로고
    • Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: An ECSG/EORTC study
    • Ravaud, A. et al. Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study. Eur. J. Cancer 41, 702-707 (2005).
    • (2005) Eur. J. Cancer , vol.41 , pp. 702-707
    • Ravaud, A.1
  • 8
    • 38149105811 scopus 로고    scopus 로고
    • The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor
    • Holen, K., Saltz, L. B., Hollywood, E., Burk, K. & Hanauske, A. R. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest New Drugs 26, 45-51 (2008).
    • (2008) Invest New Drugs , vol.26 , pp. 45-51
    • Holen, K.1    Saltz, L.B.2    Hollywood, E.3    Burk, K.4    Hanauske, A.R.5
  • 9
    • 77951887249 scopus 로고    scopus 로고
    • Safety and efficacy of NAD depleting cancer drugs: Results of a phase I clinical trial of CHS 828 and overview of published data
    • von Heideman, A., Berglund, A., Larsson, R. & Nygren, P. Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data. Cancer Chemother. Pharmacol. 65, 1165-1172 (2010).
    • (2010) Cancer Chemother. Pharmacol. , vol.65 , pp. 1165-1172
    • Von Heideman, A.1    Berglund, A.2    Larsson, R.3    Nygren, P.4
  • 10
    • 84888262057 scopus 로고    scopus 로고
    • Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens
    • Matheny, C. J. et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem. Biol. 20, 1352-1363 (2013).
    • (2013) Chem. Biol. , vol.20 , pp. 1352-1363
    • Matheny, C.J.1
  • 11
    • 84879576402 scopus 로고    scopus 로고
    • Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors
    • Zheng, X. et al. Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. J. Med. Chem. 56, 4921-4937 (2013).
    • (2013) J. Med. Chem. , vol.56 , pp. 4921-4937
    • Zheng, X.1
  • 12
    • 84889261827 scopus 로고    scopus 로고
    • Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship
    • Christensen, M. K. et al. Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship. J. Med. Chem. 56, 9071-9088 (2013).
    • (2013) J. Med. Chem. , vol.56 , pp. 9071-9088
    • Christensen, M.K.1
  • 13
    • 84894102697 scopus 로고    scopus 로고
    • Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
    • Giannetti, A. M. et al. Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). J. Med. Chem. 57, 770-792 (2014).
    • (2014) J. Med. Chem. , vol.57 , pp. 770-792
    • Giannetti, A.M.1
  • 14
    • 79952439080 scopus 로고    scopus 로고
    • A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase
    • Zhang, R. Y. et al. A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase. Anal. Biochem. 412, 18-25 (2011).
    • (2011) Anal. Biochem. , vol.412 , pp. 18-25
    • Zhang, R.Y.1
  • 15
    • 84930619097 scopus 로고    scopus 로고
    • Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase
    • Xu, T. Y. et al. Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase. Sci. Rep. 5, 10043 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 10043
    • Xu, T.Y.1
  • 16
    • 0034680606 scopus 로고    scopus 로고
    • Formal hydride transfer mechanism for photoreduction of 3-phenylquinoxalin-2-ones by amines. Association of 3-phenylquinoxalin-2-one with aliphatic amines
    • De La Fuente, J. R., Canete, A., Zanocco, A. L., Saitz, C. & Jullian, C. Formal hydride transfer mechanism for photoreduction of 3-phenylquinoxalin-2-ones by amines. Association Of 3-phenylquinoxalin-2-one with aliphatic amines. J. Org. Chem. 65, 7949-7958 (2000).
    • (2000) J. Org. Chem. , vol.65 , pp. 7949-7958
    • De La-Fuente, J.R.1    Canete, A.2    Zanocco, A.L.3    Saitz, C.4    Jullian, C.5
  • 17
    • 84961292049 scopus 로고    scopus 로고
    • Intracellular NAMPT-NAD+ -SIRT1 cascade improves post-ischaemic vascular repair by modulating notch signalling in endothelial progenitors
    • Wang, P. et al. Intracellular NAMPT-NAD+ -SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors. Cardiovasc. Res. 104, 477-488 (2014).
    • (2014) Cardiovasc. Res. , vol.104 , pp. 477-488
    • Wang, P.1
  • 18
    • 84879748358 scopus 로고    scopus 로고
    • Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay
    • Martinez Molina, D. et al. Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Science 341, 84-87 (2013).
    • (2013) Science , vol.341 , pp. 84-87
    • Martinez Molina, D.1
  • 19
    • 84923306335 scopus 로고    scopus 로고
    • FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells
    • Schuster, S. et al. FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells. Biochem. Biophys. Res. Commun. 458, 334-340 (2015).
    • (2015) Biochem. Biophys. Res. Commun. , vol.458 , pp. 334-340
    • Schuster, S.1
  • 20
    • 0242526050 scopus 로고    scopus 로고
    • FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis
    • Hasmann, M. & Schemainda, I. FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 63, 7436-7442 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 7436-7442
    • Hasmann, M.1    Schemainda, I.2
  • 21
    • 84930081819 scopus 로고    scopus 로고
    • Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer
    • Sampath, D., Zabka, T. S., Misner, D. L., O'Brien, T. & Dragovich, P. S. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer. Pharmacol. Ther. 151, 16-31 (2015).
    • (2015) Pharmacol. Ther. , vol.151 , pp. 16-31
    • Sampath, D.1    Zabka, T.S.2    Misner, D.L.3    O'Brien, T.4    Dragovich, P.S.5
  • 22
    • 84901823147 scopus 로고    scopus 로고
    • Protein kinase C epsilon regulates mitochondrial pools of nampt and NAD following resveratrol and ischemic preconditioning in the rat cortex
    • Morris-Blanco, K. C., Cohan, C. H., Neumann, J. T., Sick, T. J. & Perez-Pinzon, M. A. Protein kinase C epsilon regulates mitochondrial pools of Nampt and NAD following resveratrol and ischemic preconditioning in the rat cortex. J. Cereb. Blood Flow Metab. 34, 1024-1032 (2014).
    • (2014) J. Cereb. Blood Flow Metab. , vol.34 , pp. 1024-1032
    • Morris-Blanco, K.C.1    Cohan, C.H.2    Neumann, J.T.3    Sick, T.J.4    Perez-Pinzon, M.A.5
  • 23
    • 34548627517 scopus 로고    scopus 로고
    • Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
    • Yang, H. et al. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130, 1095-1107 (2007).
    • (2007) Cell , vol.130 , pp. 1095-1107
    • Yang, H.1
  • 24
    • 77958569431 scopus 로고    scopus 로고
    • Inhibition of nicotinamide phosphoribosyltransferase: Cellular bioenergetics reveals a mitochondrial insensitive NAD pool
    • Pittelli, M. et al. Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. J. Biol. Chem. 285, 34106-34114 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 34106-34114
    • Pittelli, M.1
  • 25
    • 1642503079 scopus 로고    scopus 로고
    • High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity
    • Rowlands, M. G. et al. High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. Anal. Biochem. 327, 176-183 (2004).
    • (2004) Anal. Biochem. , vol.327 , pp. 176-183
    • Rowlands, M.G.1
  • 26
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang, J. H., Chung, T. D. & Oldenburg, K. R. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J. Biomol. Screen 4, 67-73 (1999).
    • (1999) J. Biomol. Screen , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 27
    • 58449109119 scopus 로고    scopus 로고
    • Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: Role of nicotinamide mononucleotide
    • Wang, P. et al. Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. Cardiovasc. Res. 81, 370-380 (2009).
    • (2009) Cardiovasc. Res. , vol.81 , pp. 370-380
    • Wang, P.1
  • 28
    • 77956989433 scopus 로고
    • Cycling assay for nicotinamide adenine dinucleotides
    • Matsumura, H. & Miyachi, S. Cycling Assay for Nicotinamide Adenine Dinucleotides. Methods In Enzymology 69, 465-470 (1980).
    • (1980) Methods in Enzymology , vol.69 , pp. 465-470
    • Matsumura, H.1    Miyachi, S.2
  • 29
    • 84860561281 scopus 로고    scopus 로고
    • Loss of AMP-activated protein kinase-alpha2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle
    • Wang, P. et al. Loss of AMP-activated protein kinase-alpha2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle. Diabetes 61, 1051-1061 (2012).
    • (2012) Diabetes , vol.61 , pp. 1051-1061
    • Wang, P.1
  • 30
    • 0019781507 scopus 로고
    • Mouse liver cell culture. I. Hepatocyte isolation
    • Klaunig, J. E. et al. Mouse liver cell culture. I. Hepatocyte isolation. In Vitro 17, 913-925 (1981).
    • (1981) Vitro , vol.17 , pp. 913-925
    • Klaunig, J.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.