Nephrotoxicity in rabbits after long-term nandrolone decanoate administration

Toxicology Letters

Volumn 259, Issue , 2016, Pages 21-27

  Tsitsimpikou, Christina ^a   Vasilaki, Fotini ^b   Tsarouhas, Konstantinos ^c   Fragkiadaki, Persefoni ^b   Tzardi, Maria ^b   Goutzourelas, Nikolaos ^d   Nepka, Charitini ^c   Kalogeraki, Alexandra ^b   Heretis, Ioannis ^e   Epitropaki, Zoi ^d   Kouretas, Dimitrios ^d   Tsatsakis, Aristidis M ^b  

^a General Chemical State Laboratory   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

^c UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^d UNIVERSITY OF THESSALY   (Greece)

^e UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

Creatinine; Kidney; Nandrolone; Oxidative stress; Urea

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BIOCHEMICAL MARKER; CARBONYL DERIVATIVE; CATALASE; CREATININE; GLUTATHIONE; NANDROLONE DECANOATE; TELOMERASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UREA; ANABOLIC AGENT; BIOLOGICAL MARKER; NANDROLONE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG MEGADOSE; ENZYME ACTIVITY; HISTOPATHOLOGY; HYPEREMIA; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY PARENCHYMA; LIPID PEROXIDATION; LOW DRUG DOSE; MALE; NEPHRITIS; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT MODEL; UREA BLOOD LEVEL; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; DRUG ADMINISTRATION; DRUG EFFECTS; KIDNEY DISEASE; RABBIT;

ANABOLIC AGENTS; ANIMALS; BIOMARKERS; DRUG ADMINISTRATION SCHEDULE; KIDNEY DISEASES; MALE; NANDROLONE; OXIDATIVE STRESS; RABBITS;

EID: 84982861773     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2016.06.1122     Document Type: Article

References (47)

1. Aebi, H., Catalase in vitro. Methods Enzymol. 105 (1984), 121–126.
2. Ahmed Bin Bisher, A.S., Histopathological evidences of the nephritic pathological alterations induced by the anabolic androgenic drug (Sustanon) in male Guinea pigs (Cavia porcellus). J. Biol. Sci. 9 (2009), 514–523.
3. Ahmed, S., Passos, J.F., Birket, M.J., Beckmann, T., Brings, S., Peters, H., Birch-Machin, M.A., von Zglinicki, T., Saretzki, G., Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J. Cell Sci. 121 (2008), 1046–1053.
4. Alm-Eldeen, A., Tousson, E., Deterioration of glomerular endothelial surface layer and the alteration in the renal function after a growth promoter boldenone injection in rabbits. Hum. Exp. Toxicol. 31 (2012), 465–472.
5. Ammar, E.M., Said, S.A., Hassan, M.S., Enhanced vasoconstriction and reduced vasorelaxation induced by testosterone and nandrolone in hypercholesterolemic rabbits. Pharmacol. Res. 50 (2004), 253–259.
6. Bhatti, A.B., Usman, M., Drug targets for oxidative podocyte injury in diabetic nephropathy. Cureus, 7, 2015, e393.
7. Boada, L.D., Zumbado, M., Torres, S., Lopez, A., Diaz-Chico, B.N., Cabrera, J.J., Luzardo, O.P., Evaluation of acute and chronic hepatotoxic effects exerted by anabolic-androgenic steroid stanozolol in adult male rats. Arch. Toxicol. 73 (1999), 465–472.
8. Bricout, V., Wright, F., Update on nandrolone and norsteroids: how endogenous or xenobiotic are these substances?. Eur. J. Appl. Physiol. 92 (2004), 1–12.
9. Daher, E.F., Silva Junior, G.B., Queiroz, A.L., Ramos, L.M., Santos, S.Q., Barreto, D.M., Guimaraes, A.A., Barbosa, C.A., Franco, L.M., Patrocinio, R.M., Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review. Int. Urol. Nephrol. 41 (2009), 717–723.
10. Darke, S., Torok, M., Duflou, J., Sudden or unnatural deaths involving anabolic-androgenic steroids. J. Forensic Sci. 59 (2014), 1025–1028.
11. Divya, M.K., Lincy, L., Raghavamenon, A.C., Babu, T.D., Ameliorative effect of Apodytes dimidiata on cisplatin-induced nephrotoxicity in Wistar rats. Pharm. Biol., 2016, 1–9.
12. Frankenfeld, S.P., Oliveira, L.P., Ortenzi, V.H., Rego-Monteiro, I.C., Chaves, E.A., Ferreira, A.C., Leitao, A.C., Carvalho, D.P., Fortunato, R.S., The anabolic androgenic steroid nandrolone decanoate disrupts redox homeostasis in liver, heart and kidney of male Wistar rats. PLoS One, 16, 2014, 9 (9).
13. Germanakis, I., Tsarouhas, K., Fragkiadaki, P., Tsitsimpikou, C., Goutzourelas, N., Champsas, M.C., Stagos, D., Rentoukas, E., Tsatsakis, A.M., Oxidative stress and myocardial dysfunction in young rabbits after short term anabolic steroids administration. Food Chem Toxic 61 (2013), 101–105.
14. Geusens, P., Nandrolone decanoate: pharmacological properties and therapeutic use in osteoporosis. Clin. Rheumatol. 14:Suppl. 3 (1995), 32–39.
15. Gronbladh, A., Johansson, J., Nyberg, F., Hallberg, M., Administration of growth hormone and nandrolone decanoate alters mRNA expression of the GABAB receptor subunits as well as of the GH receptor IGF-1, and IGF-2 in rat brain. Growth Hormone IGF Res. 24 (2014), 60–66.
16. Hageloch, W., Appell, H.J., Weicker, H., 1988. [Rhabdomyolysis in a bodybuilder using anabolic steroids]. Sportverletzung Sportschaden: Organ der Gesellschaft fur Orthopadisch-Traumatologische Sportmedizin 2, 122–125.
17. Hemmersbach, P., Grosse, J., Nandrolone: a multi-faceted doping agent. Handb. Exp. Pharmacol., 2010, 127–154.
18. Herlitz, L.C., Markowitz, G.S., Farris, A.B., Schwimmer, J.A., Stokes, M.B., Kunis, C., Colvin, R.B., D'Agati, V.D., Development of focal segmental glomerulosclerosis after anabolic steroid abuse. J. Am. Soc. Nephrol. (JASN) 21 (2010), 163–172.
19. Hix, S., Kadiiska, M.B., Mason, R.P., Augusto, O., In vivo metabolism of tert-butyl hydroperoxide to methyl radicals: EPR spin-trapping and DNA methylation studies. Chem. Res. Toxicol. 13 (2000), 1056–1064.
20. Hoseini, L., Roozbeh, J., Sagheb, M., Karbalay-Doust, S., Noorafshan, A., Nandrolone decanoate increases the volume but not the length of the proximal and distal convoluted tubules of the mouse kidney. Micron 40 (2009), 226–230.
21. Iliescu, R., Cucchiarelli, V.E., Yanes, L.L., Iles, J.W., Reckelhoff, J.F., Impact of androgen-induced oxidative stress on hypertension in male SHR. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 (2007), R731–735.
22. Kanayama, G., Hudson, J.I., Pope, H.G. Jr., Long-term psychiatric and medical consequences of anabolic-androgenic steroid abuse: a looming public health concern?. Drug Alcohol Depend. 98 (2008), 1–12.
23. Kiraly, C.L., Androgenic-anabolic steroid effects on serum and skin surface lipids, on red cells, and on liver enzymes. Int. J. Sports Med. 9:4 (1988), 249–252.
24. Lu, J., Holmgren, A., The thioredoxin antioxidant system. Free Radic. Biol. Med. 66 (2014), 75–87.
25. McGuire, B.B., Watson, R.W., Perez-Barriocanal, F., Fitzpatrick, J.M., Docherty, N.G., Gender differences in the renin-angiotensin and nitric oxide systems: relevance in the normal and diseased kidney. Kidney Blood Pressure Res. 30 (2007), 67–80.
26. Mulligan, K., Zackin, R., Clark, R.A., Alston-Smith, B., Liu, T., Sattler, F.R., Delvers, T.B., Currier, J.S., Team, A.C.T.G.S., National Institute of, A., Adult, G., Effect of nandrolone decanoate therapy on weight and lean body mass in HIV-infected women with weight loss: a randomized, double-blind, placebo-controlled, multicenter trial. Arch. Intern. Med. 165 (2005), 578–585.
27. Nasr, J., Ahmad, J., Severe cholestasis and renal failure associated with the use of the designer steroid Superdrol (methasteron): a case report and literature review. Dig. Dis. Sci. 54 (2009), 1144–1146.
28. Parssinen, M., Seppala, T., Steroid use and long-term health risks in former athletes. Sports Med. 32 (2002), 83–94.
29. Parssinen, M., Seppala, T., Steroid use and long-term health risks in former athletes. Sports Med. 32:2 (2002), 83–94.
30. Piccolomini, A.F., Iskandar, M.M., Lands, L.C., Kubow, S., High hydrostatic pressure pre-treatment of whey proteins enhances whey protein hydrolysate inhibition of oxidative stress and IL-8 secretion in intestinal epithelial cells. Food Nutr. Res., 56, 2012.
31. Reddy, C.C., Tu, C.P., Burgess, J.R., Ho, C.Y., Scholz, R.W., Massaro, E.J., Evidence for the occurrence of selenium-independent glutathione peroxidase activity in rat liver microsomes. Biochem. Biophys. Res. Commun. 101 (1981), 970–978.
32. Revai, T., Sapi, Z., Benedek, S., Kovacs, A., Kaszas, I., Viranyi, M., Winkler, G., Severe nephrotic syndrome in a young man taking anabolic steroid and creatine long term. Orv. Hetil. 144 (2003), 2425–2427.
33. Riezzo, I., Turillazzi, E., Bello, S., Cantatore, S., Cerretani, D., Di Paolo, M., Fiaschi, A.I., Frati, P., Neri, M., Pedretti, M., Fineschi, V., Chronic nandrolone administration promotes oxidative stress, induction of pro-inflammatory cytokine and TNF-alpha mediated apoptosis in the kidneys of CD1 treated mice. Toxicol. Appl. Pharmacol. 280 (2014), 97–106.
34. Saborido, A., Molano, F., Megias, A., Effect of training and anabolicandrogenic steroids on drug metabolism in rat liver. Med. Sci. Sports Exerc. 25:7 (1993), 815–822.
35. Sattler, F.R., Jaque, S.V., Schroeder, E.T., Olson, C., Dube, M.P., Martinez, C., Briggs, W., Horton, R., Azen, S., Effects of pharmacological doses of nandrolone decanoate and progressive resistance training in immunodeficient patients infected with human immunodeficiency virus. J. Clin. Endocrinol. Metab. 84 (1999), 1268–1276.
36. Shahraki, M.R., Mirshekari, H., Shahraki, A.R., Chronic administration of high doses of nandrolone decanoate on the pituitary-Gonadal axis in male rats. Int. J. High Risk Behav. Addict., 15(4(3)), 2015, e24419.
37. Shokri, S., Hemadi, M., Bayat, G., Bahmanzadeh, M., Jafari-Anarkooli, I., Mashkani, B., Combination of running exercise and high dose of anabolic androgenic steroid, nandrolone decanoate, increases protamine deficiency and DNA damage in rat spermatozoa. Andrologia 46 (2014), 184–190.
38. Simons, F.E., Gu, X., Simons, K.J., Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J. Allergy Clin. Immunol. 108:5 (2001), 871–873.
39. Spanidis, Y., Mpesios, A., Stagos, D., Goutzourelas, N., Bar-Or, D., Karapetsa, M., Zakynthinos, E., Spandidos, D.A., Tsatsakis, A.M., Leon, G., Kouretas, D., Assessment of the redox status in patients with metabolic syndrome and type 2 diabetes reveals great variations. Exp. Ther. Med. 11:3 (2016), 895–903.
40. Tousson, E., El-Moghazy, M., Massoud, A., El-Atrash, A., Sweef, O., Akel, A., Physiological and biochemical changes after boldenone injection in adult rabbits. Toxicol. Ind. Health 32 (2016), 177–182.
41. Tsitsimpikou, C., Tzatzarakis, M., Fragkiadaki, P., Kovatsi, L., Stivaktakis, P., Kalogeraki, A., Kouretas, D., Tsatsakis, A.M., Histopathological lesions, oxidative stress and genotoxic effects in liver and kidneys following long term exposure of rabbits to diazinon and propoxur. Toxicology 307 (2013), 109–114.
42. Vasilaki, F., Tsitsimpikou, C., Tsarouhas, K., Germanakis, I., Tzardi, M., Kavvalakis, M., Ozcagli, E., Kouretas, D., Tsatsakis, A.M., Cardiotoxicity in rabbits after long-term nandrolone decanoate administration. Toxicol. Lett. 241 (2016), 143–151.
43. Veskoukis, A.S., Nikolaidis, M.G., Kyparos, A., Kokkinos, D., Nepka, C., Barbanis, S., Kouretas, D., Effects of xanthine oxidase inhibition on oxidative stress and swimming performance in rats. Appl. Physiol. Nutr. Metab. 33 (2008), 1140–1154.
44. Vieira, R.P., França, R.F., Damaceno-Rodrigues, N.R., Dolhnikoff, M., Caldini, E.G., Carvalho, C.R., Ribeiro, W., Dose-dependent hepatic response to subchronic administration of nandrolone decanoate. Med. Sci. Sports Exerc. 40:5 (2008), 842–847.
45. Zafiropoulos, A., Tsarouhas, K., Tsitsimpikou, C., Fragkiadaki, P., Germanakis, I., Tsardi, M., Maravgakis, G., Goutzourelas, N., Vasilaki, F., Kouretas, D., Hayes, A., Tsatsakis, A., Cardiotoxicity in rabbits after a low-level exposure to diazinon, propoxur, and chlorpyrifos. Hum. Exp. Toxicol. 33 (2014), 1241–1252.
46. Zeier, M., Schonherr, R., Amann, K., Ritz, E., Effects of testosterone on glomerular growth after uninephrectomy. Nephrol. Dial. Transplant. 13 (1998), 2234–2240.
47. de Winter, J.C.F., Using the Student's t-test with extremely small sample sizes. Pract. Assess. Res. Eval. 18:10 (2013), 1–12.