Cardiotoxicity in rabbits after a low-level exposure to diazinon, propoxur, and chlorpyrifos

Human and Experimental Toxicology

Volumn 33, Issue 12, 2014, Pages 1241-1252

  Zafiropoulos, A ^a   Tsarouhas, K ^b   Tsitsimpikou, C ^c   Fragkiadaki, P ^a   Germanakis, I ^d   Tsardi, M ^e   Maravgakis, G ^a   Goutzourelas, N ^f   Vasilaki, F ^a   Kouretas, D ^f   Hayes, A W ^g   Tsatsakis, A M ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b General Hospital of Karditsa   (Greece)

^c General Chemical State Laboratory   (Greece)

^d UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

^e UNIVERSITY OF CRETE   (Greece)

^f UNIVERSITY OF THESSALY   (Greece)

^g HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

cardiac dysfunction; chlorpyrifos; diazinon; Propoxur

Indexed keywords

CHLORPYRIFOS; DIMPYLATE; GENOMIC DNA; PROPOXUR; TELOMERASE; INSECTICIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; FEMALE; HEART FUNCTION; LONG TERM EXPOSURE; NONHUMAN; OXIDATIVE STRESS; RABBIT; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; HEART MUSCLE; METABOLISM; MONOCYTE; PATHOLOGY;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ANIMALS; CARDIOTOXICITY; CHLORPYRIFOS; DIAZINON; ECHOCARDIOGRAPHY; FEMALE; INSECTICIDES; MONOCYTES; MYOCARDIUM; OXIDATIVE STRESS; PROPOXUR; RABBITS; TELOMERASE;

EID: 84919638955     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327114532384     Document Type: Article

References (63)

1. Tsatsakis AM, Tsakalof AK, Siatitsas Y, et al. Acute poisoning with carbamate pesticides: the Cretan experience. Sci Justice. 1996 ; 36: 35-39
2. Quinn DM. Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states. Chem Rev. 1987 ; 87: 955-979
3. Teimouri F, Amirkabirian N, Esmaily H, et al. Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress. Hum Exp Toxicol. 2006 ; 25: 697-703
4. Giordano G, Afsharinejad Z, Guizzetti M, et al. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol Appl Pharmacol. 2007 ; 219: 181-189
5. Sutcu R, Altuntas I, Buyukvanli B, et al. The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat erythrocytes: role of vitamins E and C. Toxicol Indus Health. 2007 ; 23: 13-17
6. Elaziz MIA, Sahlab AM, Elkhalik A. Influence of diazinon and deltamethrine on reproductive-organs and fertility of male-rats. Deut Tierarztl Woch. 1994 ; 101: 230-232
7. Lopez DE, Carrascal E. Sensitivity of human lymphocyte chromosome to diazinon at different times during cell culture. Bull Environ Contam Toxicol. 1987 ; 38: 125-130
8. Altamirano-Lozano MA, Camacho-Manzanilla MC, Loyola-Alvarez R. Mutagenic and teratogenic effects of diazinon. Rev Int Contam Ambient. 1989 ; 5: 49-58
9. Hatjian BA, Mutch E, Williams FM, et al. Cytogenetic response without changes in peripheral cholinesterase enzymes following exposure to a sheep dip containing diazinon in vivo and in vitro. Mut Res Gen Toxicol Environ Mutagen. 2000 ; 472: 85-92
10. Kappers WA, Edwards RJ, Murray S, et al. Diazinon is activated by CYP2C19 in human liver. Toxicol Appl Pharmacol. 2001 ; 177: 68-76
11. Margariti MG, Tsatsakis AM. Assessment of long-term subacute exposure to dimethoate by hair analysis of dialkyl phosphates DMP and DMTP in exposed rabbits: the effects of dose, dose duration and hair colour. Environ Res. 2009 ; 109: 821-829
12. Rahman MF, Mahboob M, Danadevi K, et al. Assessment of genotoxic effects of chloropyriphos and acephate by the comet assay in mice leucocytes. Mut Res Gen Toxicol Environ Mutag. 2002 ; 516: 139-147
13. Elhalwagy MEA, Darwish NS, Zaher EM. Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide. Pestic Biochem Physiol. 2008 ; 91: 81-89
14. Ludomirsky A, Klein HO, Sarelli P, et al. Q-T prolongation and polymorphous ("torsade de pointes") ventricular arrhythmias associated with organophosphorus insecticide poisoning. Am J Cardiol. 1982 ; 49: 1654-1658
15. Deacon MM, Murray JS, Pilny MK. Embryotoxicity and fetotoxicity of orally administered chlorpyrifos in mice. Toxicol Appl Pharmacol. 1980 ; 54: 31-40
16. Yano BL, Young JT, Mattsson JL. Lack of carcinogenicity of chlorpyrifos insecticide in a high-dose, 2-year dietary toxicity study in Fischer 344 rats. Toxicol Sci. 2000 ; 53: 135-144
17. Lijinsky W Chemistry and biology of N-nitroso compounds. Cambridge, UK: Cambridge University Press ; 1992 :
18. Gonzalez Cid M, Loria D, Matos E. Genotoxicity of the pesticide propoxur and its nitroso derivative, NO-propoxur, on human lymphocytes in vitro. Mut Res. 1990 ; 232: 45-48
19. Millard CB, Broomfield CA. Anticholinesterases: medical applications of neurochemical principles. J Neurochem. 1995 ; 64: 1909-1918
20. Takahashi H, Kojima T, Ikeda T, et al. Differences in the mode of lethality produced through intravenous and oral administration of organophosphorus insecticides in rats. Fundam Appl Toxicol. 1991 ; 16: 459-468
21. Borison HL. Central nervous respiratory depressants - control-systems approach to respiratory depression. Pharmacol Ther B. 1977 ; 3: 211-226
22. Brimblecombe RW. Drugs acting on central cholinergic mechanisms and affecting respiration. Pharmacol Ther B. 1977 ; 3: 65-74
23. Benarroch EE, Granata AR, Ruggiero DA, et al. Neurons of C1 area mediate cardiovascular responses initiated from ventral medullary surface. Am J Physiol. 1986 ; 250: 932-945
24. Roth A, Zellinger I, Arad M, et al. Organophosphates and the heart. Chest. 1993 ; 103: 576-582
25. Karelliedde L. Organophosphorus poisoning and anesthesia. Anasthesia. 1999 ; 54: 1073-1088
26. Brill DM, Maisel AS, Prabhu R. Polymorphic ventricular tachycardia and other complex arrhythmias in organophosphate insecticide poisoning. J Electrocardiol. 1984 ; 17: 97-102
27. Wang MH, Tseng CD, Bair SY. Q-T interval prolongation and pleomorphic ventricular tachyarrhythmia ('Torsade de pointes') in organophosphate poisoning: report of a case. Hum Exp Toxicol. 1998 ; 17: 587-590
28. Saadeh AM, Farsakh NA, Al-Ali MK. Cardiac manifestations of acute carbamate and organophosphate poisoning. Heart. 1997 ; 77: 461-464
29. Rubinshtein R, Bar-Meir E, Grubstein A, et al. Early onset of ventricular tachyarrhythmias in organophosphate intoxication. Isr Med Assoc J. 2002 ; 4: 63-64
30. Karki P, Ansari JA, Bhandary S, et al. Cardiac and electrocardiographical manifestations of acute organophosphate poisoning. Singapore Med J. 2004 ; 45: 385-389
31. Eisler R Eisler's encyclopedia of environmentally hazardous priority chemicals. 1 th ed. Netherlanda, Jinarce House, Jordan Hill, Oxford, 2009. Jinarce House, Jordan Hill, Oxford: Netherlanda ; 2009 :
32. Moriya F, Hashimoto Y, Kuo T-L. Pitfalls when determing tissue distributions of organophosphorus chemicals: sodium fluoride accelerates chemical degradation. J Anal Toxicol. 1999 ; 23: 210-215
33. Veskoukis AS, Nikolaidis MG, Kyparos A, et al. Effects of xanthine oxidase inhibition on oxidative stress and swimming performance in rats. Appl Physiol Nutr Metab. 2008 ; 33: 1140-1154
34. Germanakis I, Tsarouhas K, Fragkiadaki P, et al. Oxidative stress and myocardial dysfunction in young rabbits after short term anabolic steroids administration. Food Chem Toxicol. 2013 ; 61: 101-105
35. Germanakis I, Pepes S, Sifakis S, et al. Fetal longitudinal myocardial function assessment by anatomic M-mode. Fetal Diagn Ther. 2012 ; 32: 65-71
36. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994 ; 266: 2011-2015
37. Tsirpanlis G, Chatzipanagiotou S, Boufidou F, et al. Telomerase activity is decreased in peripheral blood mononuclear cells of hemodialysis patients. Am J Nephrol. 2006 ; 26: 91-96
38. Tsitsimpikou C, Tzatzarakis M, Fragkiadaki P, et al. Histopathological lesions, oxidative stress and genotoxic effects in liver and kidneys following long term exposure of rabbits to diazinon and propoxur. Toxicology. 2013 ; 307: 109-114
39. Plehn JF, Foster E, Grice WN, et al. Echocardiographic assessment of LV mass in rabbits: models of pressure and volume overload hypertrophy. Am J Physiol. 1993 ; 265: 2066-2072
40. Fontes-Sousa AP, Bras-Silva C, Moura C, et al. M-mode and Doppler echocardiographic reference values for male New Zealand white rabbits. Am J Vet Res. 2006 ; 67: 1725-1729
41. Stypmann J, Engelen MA, Breithardt AK, et al. Doppler echocardiography and tissue Doppler imaging in the healthy rabbit: differences of cardiac function during awake and anaesthetised examination. Int J Cardiol. 2007 ; 115: 164-170
42. Moura C, Fontes-Sousa AP, Teixeira-Pinto A, et al. Agreement between echocardiographic techniques in assessment of the left ventricular myocardial performance index in rabbits. Am J Vet Res. 2009 ; 70: 464-471
43. Cetin N, Cetin E, Eraslan G, et al. Chlorpyrifos induces cardiac dysfunction in rabbits. Res Vet Sci. 2007 ; 82: 405-408
44. Germanakis I, Kalmanti M, Parthenakis F, et al. Correlation of plasma N-terminal pro-brain natriuretic peptide levels with left ventricle mass in children treated with anthracyclines. Int J Cardiol. 2006 ; 108: 212-215
45. Sinhaseni P, Samatiwat O. Toxicokinetics and safety factors in risk assessment. J Toxicol Sci. 1998 ; 23: 209-213
46. Farag AT, Eweidah MH, Tayel SM, et al. Developmental toxicity of acephate by gavage in mice. Reprod Toxicol. 2000 ; 14: 241-245
47. John M, Oommen A, Zachariah A. Muscle injury in organophosphorous poisoning and its role in the development of intermediate syndrome. Neurotoxicology. 2003 ; 24: 43-53
48. Abdou HM, ElMazoudy RH. Oxidative damage, hyperlipidemia and histological alterations of cardiac and skeletal muscles induced by different doses of diazinon in female rats. J Hazard Mater. 2010 ; 182: 273-278
49. Kodavanti UP, Moyer CF, Ledbetter AD, et al. Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto rat. Toxicol Sci. 2003 ; 71: 237-245
50. Raimondi S, Garte S, Sram RJ, et al. Effects of diet on biomarkers of exposure and effects, and on oxidative damage. Mutat Res. 2007 ; 620: 93-102
51. Douarre C, Sourbier C, Dalla Rosa I, et al. Mitochondrial topoisomerase IIs critical for mitochondrial integrity and cellular energy metabolism. PLoS One. 2012 ; 7: 41094
52. Tchantchou F, Graves M, Ashline D, et al. Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E, and apolipoprotein E. J Neurosci Res. 2004 ; 75: 508-515
53. Dorval J, Leblond VS, Hontela A. Oxidative stress and loss of cortisol secretion in adrenocortical cells of rainbow trout (Oncorhynchus mykiss) exposed in vitro to endosulfan, an organochlorine pesticide. Aquat Toxicol. 2003 ; 63: 229-241
54. Kose A, Gunay N, Yildirim C, et al. Cardiac damage in acute organophosphate poisoning in rats: effects of atropine and pralidoxime. Am J Emerg Med. 2009 ; 27: 169-175
55. Ander BP, Dupasquier CM, Prociuk MA, et al. Polyunsaturated fatty acids and their effects on cardiovascular disease. Exp Clin Cardiol. 2003 ; 8: 164-172
56. Tabo M, Komatsu R, Honda M, et al. Cardiovascular safety profile of MA-2029, a novel motilin receptor antagonist. J Toxicol Sci. 2008 ; 33: 631-639
57. Slater AF, Nobel CS, Orrenius S. The role of intracellular oxidants in apoptosis. Biochim Biophys Acta. 1995 ; 1271: 59-62
58. Saretzki G. Telomerase, mitochondria and oxidative stress. Exp Gerontol. 2009 ; 44: 485-492
59. Rentoukas E, Tsarouhas K, Kaplanis I, et al. Connection between telomerase activity in PBMC and markers of inflammation and endothelial dysfunction in patients with metabolic syndrome. PLoS One. 2012 ; 7: e35739
60. Roth A, Yssel H, Pene J, et al. Telomerase levels control the lifespan of human T lymphocytes. Blood. 2003 ; 102: 849-857
61. López-Diazguerrero N, Pérez-Figueroa GE, Martínez-Garduño CM, et al. Telomerase activity in response to mild oxidative stress. Cell Biol Int. 2012 ; 36: 409-413
62. Serra V, Von Zglinicki T, Lorenz M, et al. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows down telomere shortening. J Biol Chem. 2003 ; 278: 6824-6830
63. Ahmed S, Passos J, Birket S, et al. Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci. 2008 ; 121: 1046-1053