Physiological and biochemical changes after boldenone injection in adult rabbits

Toxicology and Industrial Health

Volumn 32, Issue 1, 2016, Pages 177-182

  Tousson, Ehab ^a   El Moghazy, Mostafa ^b   Massoud, Ahmed ^a   El Atrash, Afaf ^a   Sweef, Osama ^a   Akel, Amani ^a  

^a Tanta University   (Egypt)

^b Damietta University   (Egypt)

Author keywords

boldenone; liver and kidney functions; rabbit; sexual hormones; Steroids

Indexed keywords

ALANINE AMINOTRANSFERASE; ANABOLIC AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BOLDENONE; CREATININE; FOLLITROPIN; GLOBULIN; LUTEINIZING HORMONE; SERUM ALBUMIN; TESTOSTERONE; UREA;

ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMICAL PHENOMENA; MALE; METABOLISM; RABBIT;

ALANINE TRANSAMINASE; ANABOLIC AGENTS; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; CHEMICAL PHENOMENA; CREATININE; FOLLICLE STIMULATING HORMONE; GLOBULINS; LUTEINIZING HORMONE; MALE; RABBITS; SERUM ALBUMIN; TESTOSTERONE; UREA;

EID: 84952939120     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233713501365     Document Type: Article

References (37)

1. Alm-Eldeen A, Tousson E (2012) Deterioration of glomerular endothelial surface layer and the alteration in the renal function in Rabbits after treatment with a growth promoter Boldenone. Human and Experimental Toxicology 3: 465–472.
2. Boada LD, Zumbado SM, Torres A, López BN, Cabrera JJ, Luzardo OP (1999) Evaluation of acute and chronic hepatotoxic effects exerted by anabolic-androgenic steroid stanozolol in adult male rats. Archives of Toxicology 73: 465–472.
3. Bowers L, Wong E (1980) Kinetic serum creatinine assays. A critical evaluation and review. Clinical Chemistry 26: 555–561.
4. Cannizzo TF, Zancanaro G, Spada F, Mulasso C, Biolatti B (2007) Pathology of the testicle and sex accessory glands following the administration of boldenone and boldione as growth promoters in veal calves. Journal of Veterinary Medical Science 69: 1109–1116.
5. Dickerman RD, Pertusi RM, Zachariah NY, Dufour DR, McConathy WJ (1999) Anabolic steroidinduced hepatotoxicity: is it overstated? Clinical Journal of Sport Medicine 9: 34–39.
6. Doumas BT, Biggs HG (1972) Determination of serum globulins. In: Cooper GR (ed) Standard Methods of Clinical Chemistry.Vol. 7. New York, NY: Academic Press, pp. 175.
7. El-Moghazy M, Tousson E, Sakeran M (2012) Changes in the hepatic and renal structure and function after a growth promoter Boldenone injection in Rabbits. Animal Biology 62: 171–180.
8. Fawcett JK (1960) Determination of urea in serum. Journal of Clinical Pathology 13: 156–159.
9. Gabr FI, Shaker MH (2006) Effect of anabolic steroids (Boldenone Undecylenate) on metabolic, hormonesand reproductive performance of mature rams. Journal of Egyptian Veterinary Medical Association 66: 235–248.
10. Gabr F, Abo El-Maaty T, Amal M, Aotifa AM (2009) Effects of growth promoter boldenone undecylenate on weaned male lambs. Nature and Science 7: 61–69.
11. Groot MJ, Arts CM (1991) Histological changes in the genital tract of male veal calves after the administration of natural hormones. Archiv für Lebensmittelhygiene 42: 93–96.
12. Henry R (1974) Clinical Chemistry, Principles and Techniques. 2nd ed. New York, NY: Harper and Row, p. 415.
13. Henry RJ (1968) Determination of serum total protein. In: Clinical Chemistry Principles and Techniques. New York, NY: Harper and Row, pp 85.
14. Hoffmann U (2002) Anabolic steroids: a problem in popular sports. Toxichem Krimtech 69: 136.
15. Hughes TK, Fulep E, Juelich T, Smith EM, Stanton GJ (1995) Modulation of immune responses by anabolic-androgenic steroids. International Journal of Immunopharmacology 17: 857–863.
16. Istasse L, Evrard P, Van Eenaeme C, Gielen M, Maghuin-Rogister G, Bienfait JM (1988) Trenbolone acetate in combination with 17beta-estradiol: influence of implant supports and dose levels on animal performance and plasma metabolites. Journal of Animal Science 66: 1212–1222.
17. Jockenhovel F, Bullmann C, Schubert M, Vogel E, Reinhardt W, Reinwein D et al. (1999) Influence of various modes of androgen substitution on serum lipids and lipoproteins in hypogonadal men. Metabolism 48: 590–596.
18. Kicman AT (2008) Pharmacology of anabolic steroids. British Journal of Pharmacology 154: 502.
19. Kuhn CM (2002) Anabolic steroids. Recent Progress in Hormone Research 57: 411–434.
20. Pey A, Blázquez I, Delgad J, Megıas A (2003) Effects of prolonged stanozolol treatment on antioxidant enzyme activities, oxidative stress markers, and heat shock protein HSP72 levels in rat liver. Journal of Steroid Biochemistry 87: 269–277.
21. Pompa G, Arioli F, Fracchiolla ML, Sgoifo CA, Bassini AL, Stella S et al. (2006) Food additives. Contaminants 23: 126.
22. Rodriguez BM, Mendez Sanchez A, Blanco Rodriguez A (1991) Comparative morphological studies of lamb and calf Sertoli cells treated with anabolic agent. Histology and Histopathology 6: 171–174.
23. Schänzer W (1996) Metabolism of anabolic-androgenic steroids. Clinical Chemistry 42: 1001–1020.
24. Shimomura K, Shimada M, Hagiwara M, Harada S, Kato M, Furuhama K (2005) Insights into testicular damage induced by ethinylestradiol in rats. Reproductive Toxicology 20: 157–163.
25. Silcox RW, Keeton JT, Johnson BH (1986) Effects of zeranol and trenbolone acetate on testis function, live weight gain and carcass traits of bulls. Journal of Animal Science 63: 358–368.
26. Simontacchi C, Perez de Altamirano T, Marinelli L, Angeletti R, Gabai G (2004) Plasma steroid variations in bull calves repeatedly treated with testosterone, nortestosterone and oestradiol administered alone or in combination. Veterinary Research Communications 28: 467–477.
27. Soma LR, Uboh CE, Guan F, MC-Donnell S, Pack J (2007) Pharmacokinetics of boldenone and stanozolol and the results of quantification of anabolic-androgenic steroids in race horses and nonrace horses. Journal of Veterinary Pharmacology and Therapeutics 30: 101–108.
28. Sullivan ML, Martinez CM, Gennis P, Gallagher EJ (1998) The cardiac toxicity of anabolic steroids. Progress in Cardiovascular Diseases 41: 1–15.
29. Sundlof SF (2001) Legal control of veterinary drugs. In: Adams HR (ed) Veterinary Pharmacology Therapeutics. 8th ed. p. 1155. Ames, IA: Iowa State University Press.
30. Takahashi M, Tatsugi Y, Kohno T (2004) Endocrinological and pathological effects of anabolic-androgenic steroid in male rats. Endocrine Journal 51: 425–434.
31. Tietz NW (1994). Textbook of clinical chemistry 2nd ed. In: Burtis CA, Ashwood ER (eds), UK: W.B. Saunders Co.
32. Tousson E, Alm-Eldeen A, El-Moghazy M (2011a) p53 and Bcl-2 expression in response to boldenone induced liver cells injury. Toxicology and Industrial Health 27: 711–718.
33. Tousson E, El-Gerbed MSA, Shaleby S (2011b) Effects of maturity on histopathological alteration after a growth promoter boldenone injection in rabbits. Journal of American Science 7: 1074–1080.
34. Tousson E, El-Moghazy M, Massoud A, Akel A (2012) Histopathological and immunohistochemical changes in the testes of rabbits after injection with the growth promoter boldenone. Reproductive Sciences 19: 253–259.
35. Urhausen A, Torsten A, Wilfried K (2003) Reversibility of the effects on blood cells, lipids, liver function and hormones in former anabolic-androgenic steroid abusers. Journal of Steroid Biochemistry and Molecular Biology 84: 369–375.
36. Welder AA, Robertson JW, Melchert RB (1995) Toxic effects of anabolic-androgenic steroids in primary rat hepatic cultures. Journal of Pharmacological and Toxicological Methods 33: 187–195.
37. Yesalis CE, Kennedy NJ, Kopstein AN, Bahrke MS (1993) Anabolic-androgenic steroid use in the United States. Journal of the American Veterinary Medical Association 270: 1217–1221.