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Volumn 73, Issue 8-9, 1999, Pages 465-472

Evaluation of acute and chronic hepatotoxic effects exerted by anabolic- androgenic steroid stanozolol in adult male rats

Author keywords

Cell cycle; Hepatotoxicity; Monooxygenase enzymes; S phase; Stanozolol

Indexed keywords

ALANINE AMINOTRANSFERASE; ANABOLIC AGENT; ANDROGEN; ASPARTATE AMINOTRANSFERASE; CYTOCHROME B5; CYTOCHROME P450; STANOZOLOL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNSPECIFIC MONOOXYGENASE;

EID: 0033406253     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050636     Document Type: Article
Times cited : (66)

References (40)
  • 1
    • 0017797324 scopus 로고
    • Optimization of methods for aspartate aminotransferase and alanine amino-transferase
    • Bergmeyer HU, Scheibe P, Wahlefeld AW (1978) Optimization of methods for aspartate aminotransferase and alanine amino-transferase. Clin Chem 24: 58-73
    • (1978) Clin Chem , vol.24 , pp. 58-73
    • Bergmeyer, H.U.1    Scheibe, P.2    Wahlefeld, A.W.3
  • 3
    • 0342560982 scopus 로고
    • The liver: The mitotic origin of polyploid cells
    • Brodsky VY, Uryvaeva IV (eds) Cambridge University Press, Cambridge
    • Brodsky VY, Uryvaeva IV (1985) The liver: the mitotic origin of polyploid cells. In: Brodsky VY, Uryvaeva IV (eds) Genome multiplication in growth and development. Cambridge University Press, Cambridge, pp 22-37
    • (1985) Genome Multiplication in Growth and Development , pp. 22-37
    • Brodsky, V.Y.1    Uryvaeva, I.V.2
  • 4
    • 49549138165 scopus 로고
    • Structure and effects of anabolic steroids
    • Camerino B, Sciaky R (1975) Structure and effects of anabolic steroids. Pharmacol Ther [B] 1: 233-275
    • (1975) Pharmacol Ther [B] , vol.1 , pp. 233-275
    • Camerino, B.1    Sciaky, R.2
  • 5
    • 0013595461 scopus 로고
    • Anabolic steroids
    • De Groot LJ (ed) Saunders and Co., Philadelphia
    • Catlin D (1995) Anabolic steroids. In: De Groot LJ (ed) Endocrinology. Saunders and Co., Philadelphia, pp 2362-2376
    • (1995) Endocrinology , pp. 2362-2376
    • Catlin, D.1
  • 6
    • 0025127633 scopus 로고
    • Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal
    • Esterbauer H, Cheeseman KH (1990) Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 186: 407-421
    • (1990) Methods Enzymol , vol.186 , pp. 407-421
    • Esterbauer, H.1    Cheeseman, K.H.2
  • 7
    • 0028328702 scopus 로고
    • Stanozolol and danazol, unlike natural androgens interact with the low affinity glucocorticoid-binding sites from male rat liver microsomes
    • Fernández L, Chirino R, Boada LD, Navarro D, Cabrera N, del Río I, Díaz-Chico BN (1994) Stanozolol and danazol, unlike natural androgens interact with the low affinity glucocorticoid-binding sites from male rat liver microsomes. Endocrinology 134: 1401-1408
    • (1994) Endocrinology , vol.134 , pp. 1401-1408
    • Fernández, L.1    Chirino, R.2    Boada, L.D.3    Navarro, D.4    Cabrera, N.5    Del Río, I.6    Díaz-Chico, B.N.7
  • 10
    • 0026503180 scopus 로고
    • Assay for tumor initiating and promoting activity in two rat liver foci bioassays
    • Ghia M, Mereto E (1992) Assay for tumor initiating and promoting activity in two rat liver foci bioassays. Cancer Lett 63: 203-209
    • (1992) Cancer Lett , vol.63 , pp. 203-209
    • Ghia, M.1    Mereto, E.2
  • 11
    • 0024236331 scopus 로고
    • The molecular biology of cytochrome P450s
    • Gonzalez FJ (1989) The molecular biology of cytochrome P450s. Pharmacol Rev 40: 243-288
    • (1989) Pharmacol Rev , vol.40 , pp. 243-288
    • Gonzalez, F.J.1
  • 12
    • 0017764686 scopus 로고
    • Metabolism of vinyl chloride: Destruction of the heme of highly purified liver microsomal cytochrome P-450 by a metabolite
    • Guengerich FP, Strickland TW (1977) Metabolism of vinyl chloride: destruction of the heme of highly purified liver microsomal cytochrome P-450 by a metabolite. Mol Pharmacol 13: 993-1004
    • (1977) Mol Pharmacol , vol.13 , pp. 993-1004
    • Guengerich, F.P.1    Strickland, T.W.2
  • 13
    • 0002227995 scopus 로고
    • Androgen physiology: Testosterone and other androgens: Physiology, pharmacology and therapeutic use
    • De Groot LJ (ed) Saunders and Co., Philadelphia
    • Handelsman DJ (1995) Androgen physiology: testosterone and other androgens: physiology, pharmacology and therapeutic use. In: De Groot LJ (ed) Endocrinology. Saunders and Co., Philadelphia, pp 2351-2361
    • (1995) Endocrinology , pp. 2351-2361
    • Handelsman, D.J.1
  • 14
    • 0031172481 scopus 로고    scopus 로고
    • Hepatic ploidy, nuclearity, and distribution of DNA synthesis: A comparison of nongenotoxic hepatocarcinogens with noncarcinogenic liver mitogens
    • Hasmall SC, Roberts RA (1997) Hepatic ploidy, nuclearity, and distribution of DNA synthesis: a comparison of nongenotoxic hepatocarcinogens with noncarcinogenic liver mitogens. Toxicol Appl Pharmacol 144: 287-293
    • (1997) Toxicol Appl Pharmacol , vol.144 , pp. 287-293
    • Hasmall, S.C.1    Roberts, R.A.2
  • 15
    • 0021735872 scopus 로고
    • Anabolic steroids: A review of the literature
    • Haupt H, Rovere G (1984) Anabolic steroids: a review of the literature. Am J Sports Med 12: 469-484
    • (1984) Am J Sports Med , vol.12 , pp. 469-484
    • Haupt, H.1    Rovere, G.2
  • 16
    • 0023864748 scopus 로고
    • Deleterious effects of anabolic steroids on serum lipoprotein, blood presssure and liver function in amateur bodybuilders
    • Lenders JW, Demacker PN, Vos JA, Jansen PL, Hoitsma AJ, van't Laar A, Thien T (1988) Deleterious effects of anabolic steroids on serum lipoprotein, blood presssure and liver function in amateur bodybuilders. Int J Sports Med 9: 19-23
    • (1988) Int J Sports Med , vol.9 , pp. 19-23
    • Lenders, J.W.1    Demacker, P.N.2    Vos, J.A.3    Jansen, P.L.4    Hoitsma, A.J.5    Van't Laar, A.6    Thien, T.7
  • 17
    • 0027477558 scopus 로고
    • Current perspectives on anabolic- androgenic abuse
    • Lukas SE (1993) Current perspectives on anabolic- androgenic abuse. Trends Pharmacol Sci 14: 61-68
    • (1993) Trends Pharmacol Sci , vol.14 , pp. 61-68
    • Lukas, S.E.1
  • 18
    • 0027056720 scopus 로고
    • Ethinyl estradiol-induced cell proliferation in rat liver. Involvement of specific populations of hepatocytes
    • Mayol X, Neal GE, Davies R, Romero A, Domingo J (1992) Ethinyl estradiol-induced cell proliferation in rat liver. Involvement of specific populations of hepatocytes. Carcino-genesis 13: 2381-2388
    • (1992) Carcino-genesis , vol.13 , pp. 2381-2388
    • Mayol, X.1    Neal, G.E.2    Davies, R.3    Romero, A.4    Domingo, J.5
  • 20
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes, I. Evidence for its haemoprotein nature
    • Omura T, Sato R (1964) The carbon monoxide-binding pigment of liver microsomes, I. Evidence for its haemoprotein nature. J Biol Chem 239: 2370-2379
    • (1964) J Biol Chem , vol.239 , pp. 2370-2379
    • Omura, T.1    Sato, R.2
  • 21
    • 0018437950 scopus 로고
    • Self-catalyzed destruction of cytochrome P-450: Covalent binding of ethynyl sterols to prosthetic heme
    • Ortiz de Montellano P, Kuntze K, Yost G, Mico B (1979) Self-catalyzed destruction of cytochrome P-450: Covalent binding of ethynyl sterols to prosthetic heme. Proc Natl Acad Sci USA76: 746-749
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 746-749
    • Ortiz De Montellano, P.1    Kuntze, K.2    Yost, G.3    Mico, B.4
  • 22
    • 0017209208 scopus 로고
    • Intrahepatic cholestasis induced by drugs and chemicals
    • Plaa GL, Priestly BG (1976) Intrahepatic cholestasis induced by drugs and chemicals. Pharmacol Rev 28: 207-273
    • (1976) Pharmacol Rev , vol.28 , pp. 207-273
    • Plaa, G.L.1    Priestly, B.G.2
  • 23
    • 0023871971 scopus 로고
    • Interaction of stanozolol with cytochrome P-450
    • Rendic S, Ruf HH (1988) Interaction of stanozolol with cytochrome P-450. Biochem Pharmacol 37: 766-768
    • (1988) Biochem Pharmacol , vol.37 , pp. 766-768
    • Rendic, S.1    Ruf, H.H.2
  • 24
    • 0343430894 scopus 로고
    • Anabolic androgenic steroids (AAS): Structure, nomenclature and classification, biological properties
    • CRC Press (eds) CRC Press, Boca Ratón, Florida
    • Rogozkin VA (1991) Anabolic androgenic steroids (AAS): structure, nomenclature and classification, biological properties. In: CRC Press (eds) Metabolism of AAS. CRC Press, Boca Ratón, Florida, pp 1-23
    • (1991) Metabolism of AAS , pp. 1-23
    • Rogozkin, V.A.1
  • 25
    • 85043334396 scopus 로고
    • Effects of anabolizing androgens on hepatic monooxygenase activities
    • Shipe JR, Savory J (eds) Blackwell Scientific Publications, Oxford
    • Saborido A, Vila J, Odriozola JM, Megías A (1991) Effects of anabolizing androgens on hepatic monooxygenase activities. In: Shipe JR, Savory J (eds) Drugs in competitive athletics, Blackwell Scientific Publications, Oxford, pp 121-125
    • (1991) Drugs in Competitive Athletics , pp. 121-125
    • Saborido, A.1    Vila, J.2    Odriozola, J.M.3    Megías, A.4
  • 26
    • 0027284210 scopus 로고
    • Effect of training and anabolic- androgenic steroids on drug metabolism in rat liver
    • Saborido A, Molano F, Megías A (1993) Effect of training and anabolic- androgenic steroids on drug metabolism in rat liver. Med Sci Sports Exerc 25: 815-822
    • (1993) Med Sci Sports Exerc , vol.25 , pp. 815-822
    • Saborido, A.1    Molano, F.2    Megías, A.3
  • 27
    • 0023915070 scopus 로고
    • Quantitative structure-activity studies on effects of sixteen different steroids on growth and monoxygenases of rat liver
    • Schulte-Hermann R, Ochs H, Bursch W, Parzefall W (1988) Quantitative structure-activity studies on effects of sixteen different steroids on growth and monoxygenases of rat liver. Cancer Res 48: 2462-2468
    • (1988) Cancer Res , vol.48 , pp. 2462-2468
    • Schulte-Hermann, R.1    Ochs, H.2    Bursch, W.3    Parzefall, W.4
  • 28
    • 0026631535 scopus 로고
    • Liver pathology associated with the use of anabolic- androgenic steroids
    • Soe KL, Soe M, Gluud C (1992) Liver pathology associated with the use of anabolic- androgenic steroids. Liver 12: 73-79
    • (1992) Liver , vol.12 , pp. 73-79
    • Soe, K.L.1    Soe, M.2    Gluud, C.3
  • 29
    • 0017120644 scopus 로고
    • Hepatic lesions in patients treated with synthetic anabolic steroids
    • Sweeney E, Evans D (1976) Hepatic lesions in patients treated with synthetic anabolic steroids. J Clin Pathol 29: 626-633
    • (1976) J Clin Pathol , vol.29 , pp. 626-633
    • Sweeney, E.1    Evans, D.2
  • 30
    • 0022796048 scopus 로고
    • The influence of dose of pheno-barbital and interval to measurement on concentration of liver enzymes in parrots and gilts
    • Thomford PJ, Dziuk PJ (1986) The influence of dose of pheno-barbital and interval to measurement on concentration of liver enzymes in parrots and gilts. J Anim Sci 63: 1184-1190
    • (1986) J Anim Sci , vol.63 , pp. 1184-1190
    • Thomford, P.J.1    Dziuk, P.J.2
  • 33
    • 0025653461 scopus 로고
    • An integrated set of methods for routine flow cytometric DNA analysis
    • Vindelov L, Christensen IJ (1990) An integrated set of methods for routine flow cytometric DNA analysis. Method Cell Biol 33: 127-137
    • (1990) Method Cell Biol , vol.33 , pp. 127-137
    • Vindelov, L.1    Christensen, I.J.2
  • 34
    • 0029083424 scopus 로고
    • Toxic effects of anabolic- androgenic steroids in primary rat hepatic cell cultures
    • Welder AA, Robertson JW, Melchert RB (1995) Toxic effects of anabolic- androgenic steroids in primary rat hepatic cell cultures. J Pharmacol Toxicol Methods 33: 187-195
    • (1995) J Pharmacol Toxicol Methods , vol.33 , pp. 187-195
    • Welder, A.A.1    Robertson, J.W.2    Melchert, R.B.3
  • 35
    • 0018186104 scopus 로고
    • Metabolic activation of acetylenic substituents to derivatives in the rat causing the loss of hepatic cytochrome P-450 and haem
    • White IN (1978) Metabolic activation of acetylenic substituents to derivatives in the rat causing the loss of hepatic cytochrome P-450 and haem. Biochem J 174: 853-861
    • (1978) Biochem J , vol.174 , pp. 853-861
    • White, I.N.1
  • 36
    • 0019295784 scopus 로고
    • The use and misuse of androgens
    • Wilson J, Griffin J (1980) The use and misuse of androgens. Metabolism 29: 1278-1295
    • (1980) Metabolism , vol.29 , pp. 1278-1295
    • Wilson, J.1    Griffin, J.2
  • 37
    • 0026603074 scopus 로고
    • Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan
    • Wilson DM, Godsworthy TL, Popp JA, Butterworth BE (1992) Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan. Environ Mol Mutagen 19: 209-222
    • (1992) Environ Mol Mutagen , vol.19 , pp. 209-222
    • Wilson, D.M.1    Godsworthy, T.L.2    Popp, J.A.3    Butterworth, B.E.4
  • 38
    • 0026065862 scopus 로고
    • Synthetic estrogens and tamoxifen as promoters of hepatocarcinogenesis
    • Yager JD, Shi YE (1991) Synthetic estrogens and tamoxifen as promoters of hepatocarcinogenesis. Prev Med 20: 27-37
    • (1991) Prev Med , vol.20 , pp. 27-37
    • Yager, J.D.1    Shi, Y.E.2
  • 39
    • 0027996471 scopus 로고
    • Growth stimulation followed by growth inhibition in livers of female rats treated with ethinylestradiol
    • Yager JD, Zurlo J, Sewall C, Lucier G, Hongchin H (1994) Growth stimulation followed by growth inhibition in livers of female rats treated with ethinylestradiol. Carcinogenesis 15: 2117-2123
    • (1994) Carcinogenesis , vol.15 , pp. 2117-2123
    • Yager, J.D.1    Zurlo, J.2    Sewall, C.3    Lucier, G.4    Hongchin, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.