The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

Annals of the Rheumatic Diseases

Volumn 76, Issue 3, 2017, Pages 576-584

  Dudek, Michal ^a,b   Yang, Nan ^a,b   Ruckshanthi, Jayalath P D ^a,b   Williams, Jack ^a,b   Borysiewicz, Elzbieta ^a   Wang, Ping ^a   Adamson, Antony ^a   Li, Jian ^a   Bateman, John F ^c   White, Michael R ^a   Boot Handford, Raymond P ^b   Hoyland, Judith A ^d,e   Meng, Qing Jun ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Arthritis; Chondrocytes; Cytokines; Low Back Pain

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTOME; TUMOR NECROSIS FACTOR; ARNTL PROTEIN, HUMAN; ARNTL PROTEIN, MOUSE; CIRCADIAN RHYTHM SIGNALING PROTEIN; CLOCK PROTEIN, HUMAN; CLOCK PROTEIN, MOUSE; PER2 PROTEIN, HUMAN; PER2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR CLOCK;

AGE; AGING; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; BMAL1 GENE; BODY TEMPERATURE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERVERTEBRAL DISK DEGENERATION; KNOCKOUT MOUSE; LOW BACK PAIN; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; INTERVERTEBRAL DISK; METABOLISM; NUCLEUS PULPOSUS; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TEMPERATURE; TISSUE CULTURE TECHNIQUE;

AGE FACTORS; AGING; ANIMALS; ARNTL TRANSCRIPTION FACTORS; CELLS, CULTURED; CIRCADIAN CLOCKS; CIRCADIAN RHYTHM; CLOCK PROTEINS; HUMANS; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MICE; MICE, KNOCKOUT; NF-KAPPA B; NUCLEUS PULPOSUS; PERIOD CIRCADIAN PROTEINS; SIGNAL TRANSDUCTION; TEMPERATURE; TISSUE CULTURE TECHNIQUES; TRANSCRIPTOME; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84982840935     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2016-209428     Document Type: Article

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