Gremlin-2 is a BMP antagonist that is regulated by the circadian clock

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Yeung, Ching Yan Chloé ^a,b   Gossan, Nicole ^a,b   Lu, Yinhui ^a,b   Hughes, Alun ^b   Hensman, James J ^c   Bayer, Monika L ^d   Kjær, Michael ^d   Kadler, Karl E ^a,b   Meng, Qing Jun ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BMP2 PROTEIN, HUMAN; BMP2 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN 2; GREM2 PROTEIN, MOUSE; MESSENGER RNA; PROTEIN;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL DIFFERENTIATION; CIRCADIAN RHYTHM; CYTOLOGY; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; PHOSPHORYLATION; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TENDON; TIME FACTOR; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELLS, CULTURED; CIRCADIAN CLOCKS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOENZYME TECHNIQUES; MICE; PHOSPHORYLATION; PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TENDONS; TIME FACTORS;

EID: 84902106530     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05183     Document Type: Article

References (37)

1. Chaudhury, S., Holland, C., Thompson, M. S., Vollrath, F. & Carr, A. J. Tensileand shear mechanical properties of rotator cuff repair patches. J Shoulder ElbowSurg 21, 1168 (2012).
2. Butler, D. L. et al. Functional tissue engineering for tendon repair: Amultidisciplinary strategy using mesenchymal stem cells, bioscaffolds, andmechanical stimulation. J Orthop Res 26, 1 (2008).
3. Oliva, F., Barisani, D., Grasso, A. & Maffulli, N. Gene expression analysis incalcific tendinopathy of the rotator cuff. Eur Cell Mater 21, 548 (2011).
4. Lippmann, R. K. Observations concerning the calcific cuff deposit. Clin Orthop 20,49 (1961).
5. Welfling, J., Kahn,M. F., Desroy, M., Paolaggi, J. B. & de Seze, S. [Calcifications ofthe shoulder. II. The disease of multiple tendinous calcifications]. Rev Rhum MalOsteoartic 32, 325 (1965).
6. Uhthoff, H. K. & Loehr, J. W. Calcific Tendinopathy of the Rotator Cuff:Pathogenesis, Diagnosis, and Management. J AmAcad Orthop Surg 5, 183 (1997).
7. Oliva, F., Via, A. G. & Maffulli, N. Physiopathology of intratendinous calcificdeposition. BMC Med 10, 95 (2012).
8. McCarthy, J. J. et al. Identification of the circadian transcriptome in adult mouseskeletal muscle. Physiol. Genomics 31, 86 (2007).
9. Gossan, N. et al. The circadian clock in murine chondrocytes regulates genescontrolling key aspects of cartilage homeostasis. Arthritis Rheum 65, 2334 (2013).
10. Bunger, M. K. et al. Progressive arthropathy in mice with a targeted disruption ofthe Mop3/Bmal-1 locus. Genesis 41, 122 (2005).
11. Vitaterna, M. H. et al.Mutagenesis and mapping of amouse gene, Clock, essentialfor circadian behavior. Science 264, 719 (1994).
12. Yoo, S. H. et al. PERIOD2::LUCIFERASE real-time reporting of circadiandynamics reveals persistent circadian oscillations in mouse peripheral tissues.Proc Natl Acad Sci USA 101, 5339 (2004).
13. Hsu, D. R., Economides, A. N., Wang, X., Eimon, P. M. & Harland, R. M. TheXenopus dorsalizing factor Gremlin identifies a novel family of secreted proteinsthat antagonize BMP activities. Mol Cell 1, 673 (1998).
14. Miyazawa, K., Shinozaki, M., Hara, T., Furuya, T. & Miyazono, K. Two majorSmad pathways in TGF-beta superfamily signalling. Genes Cells 7, 1191 (2002).
15. Hollnagel, A., Oehlmann, V., Heymer, J., Ruther, U. & Nordheim, A. Id genes aredirect targets of bone morphogenetic protein induction in embryonic stem cells.J Biol Chem 274, 19838 (1999).
16. Yang, J. et al. Id proteins are critical downstream effectors of BMP signaling inhuman pulmonary arterial smooth muscle cells. Amer J Physiol (2013).
17. Maronde, E. et al. The clock genes Period 2 and Cryptochrome 2 differentiallybalance bone formation. PloS one 5, e11527 (2010).
18. Takarada, T. et al. Clock genes influence gene expression in growth plate andendochondral ossification in mice. J Biol Chem 287, 36081 (2012).
19. Andrews, J. L. et al. CLOCK and BMAL1 regulate MyoD and are necessary formaintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci USA107, 19090 (2010).
20. Wakefield, L. M.&Hill, C. S. Beyond TGFbeta: roles of other TGFbeta superfamilymembers in cancer. Nat Rev Cancer 13, 328 (2013).
21. Topol, L. Z. et al. Biosynthesis, post-translation modification, and functionalcharacterization of Drm/Gremlin. J Biol Chem 275, 8785 (2000).
22. Topol, L. Z. et al. Identification of drm, a novel gene whose expression issuppressed in transformed cells and which can inhibit growth of normal but nottransformed cells in culture. Mol Cell Biol 17, 4801 (1997).
23. Bragdon, B. et al. Bone morphogenetic proteins: a critical review. Cell Signal 23,609 (2011).
24. McMahon, R. et al. IHG-2, a mesangial cell gene induced by high glucose, ishuman gremlin. Regulation by extracellular glucose concentration, cyclicmechanical strain, and transforming growth factor-beta1. J Biol Chem 275, 9901(2000).
25. Wordinger, R. J., Zode, G.& Clark, A. F. Focus on molecules: gremlin. Exp Cell Res87, 78 (2008).
26. Sudo, S., Avsian-Kretchmer, O.,Wang, L. S.&Hsueh, A. J. Protein related toDANand cerberus is a bone morphogenetic protein antagonist that participates inovarian paracrine regulation. J Biol Chem 279, 23134 (2004).
27. Zuniga, E., Rippen, M., Alexander, C., Schilling, T. F. & Crump, J. G. Gremlin 2regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventralpatterning of the facial skeleton. Development 138, 5147 (2011).
28. Muller, II et al. Functional modeling in zebrafish demonstrates that the atrialfibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocytedifferentiation and atrial rhythm. Dis Model Mech 6, 332 (2013).
29. Tanwar, V. et al. Gremlin 2 promotes differentiation of embryonic stem cells toatrial fate by activation of the JNK signaling pathway. Stem Cells (2014).
30. Rui, Y. F. et al.Mechanical loading increased BMP-2 expression which promotedosteogenic differentiation of tendon-derived stem cells. J Orthop Res 29, 390(2011).
31. Neuwirth, J. et al. Expression of bioactive bone morphogenetic proteins in thesubacromial bursa of patients with chronic degeneration of the rotator cuff.Arthritis Res Therapy 8, R92 (2006).
32. Brown, S. A., Pagani, L.,Cajochen,C.&Eckert, A. Systemic and cellular reflectionson ageing and the circadian oscillator: a mini-review. Gerontology 57, 427 (2011).
33. Meng, Q. J. et al. Ligand modulation of REV-ERBalpha function resets theperipheral circadian clock in a phasic manner. J Cell Sci 121, 3629 (2008).
34. Hughes, M. E., Hogenesch, J. B. & Kornacker, K. JTK-CYCLE: an efficientnonparametric algorithm for detecting rhythmic components in genome-scaledata sets. J Biol Rhythms 25, 372 (2010).
35. Strimmer, K. fdrtool: a versatile R package for estimating local and tail area-basedfalse discovery rates. Bioinformatics 24, 1461 (2008).
36. Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data usingreal-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25,402 (2001).
37. Bayer, M. L. et al. The initiation of embryonic-like collagen fibrillogenesis by adulthuman tendon fibroblasts when cultured under tension. Biomaterials 31, 4889(2010).