Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFkB-dependent pathway

Osteoarthritis and Cartilage

Volumn 23, Issue 11, 2015, Pages 1981-1988

  Guo, B ^a   Yang, N ^a   Borysiewicz, E ^a   Dudek, M ^a   Williams, J L ^a   Li, J ^a,b   Maywood, E S ^c   Adamson, A ^a   Hastings, M H ^c   Bateman, J F ^d   White, M R H ^a   Boot Handford, R P ^e   Meng, Q J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b TAISHAN MEDICAL UNIVERSITY   (China)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cartilage; Circadian clock; Cytokine; Inflammation; Osteoarthritis

Indexed keywords

CYTOKINE; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK; TUMOR NECROSIS FACTOR ALPHA; DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MONITORING; BIOLUMINESCENCE; CARTILAGE CELL; CARTILAGE EXPLANT; CATABOLISM; CELL LINE; CHONDROPATHY; CIRCADIAN RHYTHM; CLOCK CONTROLLED CATABOLIC GENE; CONTROLLED STUDY; EX VIVO STUDY; FLUORESCENCE IMAGING; FUNCTIONAL ASSESSMENT; GENE; GENE DISRUPTION; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR CLOCK; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SW 1353 CELL; ANIMAL; ARTICULAR CARTILAGE; BIOSYNTHESIS; CELL CULTURE; CHONDROCYTE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; CIRCADIAN CLOCKS; CYTOKINES; DISEASE MODELS, ANIMAL; DNA; GENE EXPRESSION REGULATION; MICE; MICE, TRANSGENIC; NF-KAPPA B; OSTEOARTHRITIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84945310610     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.02.020     Document Type: Article

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