Safety profile of solid lipid nanoparticles loaded with rosmarinic acid for oral use: In vitro and animal approaches

International Journal of Nanomedicine

Volumn 11, Issue , 2016, Pages 3621-3640

  Madureira, Ana Raquel ^a   Nunes, Sara ^b   Campos, Débora A ^a   Fernandes, João C ^b   Marques, Cláudia ^c   Zuzarte, Monica ^b   Gullón, Beatriz ^a   Rodríguez Alcalá, Luís M ^a   Calhau, Conceição ^c,d   Sarmento, Bruno ^e,f,g   Gomes, Ana Maria ^a   Pintado, Maria Manuela ^a   Reis, Flávio ^b  

^a CBQF CENTRO DE BIOTECNOLOGIA E QUÍMICA FINA LABORATÓRIO ASSOCIADO   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c University of Porto   (Portugal)

^d UNIVERSITY OF PORTO   (Portugal)

^e INSTITUTO DE INVESTIGAÇÃO E FORMAÇÃO AVANÇADA EM CIÊNCIAS E TECNOLOGIAS DA SAÚDE   (Portugal)

^f UNIVERSITY OF PORTO   (Portugal)

^g INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

Author keywords

In vitro and animal toxicity; Rosmarinic acid; Safety profile; Solid lipid nanoparticles; Witepsol and Carnauba waxes

Indexed keywords

CARNAUBA; CYCLOPHOSPHAMIDE; DNA; FATTY ACID; ROSMARINIC ACID; SALVIA OFFICINALIS EXTRACT; SOLID LIPID NANOPARTICLE; STAUROSPORINE; UNCLASSIFIED DRUG; WAX; WITEPSOL; CARNAUBA WAX; CINNAMIC ACID DERIVATIVE; DEPSIDE; LIPID; NANOPARTICLE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; MALE; NANOTOXICOLOGY; NONHUMAN; OXIDATION REDUCTION STATE; RAT; SAFETY; ANIMAL; CELL SURVIVAL; CHEMISTRY; CYTOKINESIS; DRUG EFFECTS; LYMPHOCYTE; METABOLISM; ORAL DRUG ADMINISTRATION; OXIDATION REDUCTION REACTION; REAL TIME POLYMERASE CHAIN REACTION; ULTRASTRUCTURE; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; CELL SURVIVAL; CINNAMATES; CYTOKINESIS; DEPSIDES; DNA; GASTROINTESTINAL MICROBIOME; LIPIDS; LYMPHOCYTES; MALE; NANOPARTICLES; OXIDATION-REDUCTION; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; TRIGLYCERIDES; WAXES;

EID: 84982730509     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S104623     Document Type: Article

References (48)

1. Nunes S, Madureira R, Campos D, et al. Therapeutic and nutraceutical potential of rosmarinic acid-cytoprotective properties and pharmacokinetic profile. Crit Rev Food Sci Nutr. Epub June 26, 2015.
2. Petersen M, Simmonds MS. Rosmarinic acid. Phytochemistry. 2003;62:121–125.
3. Shen J, Gao G, Liu X, Fu J. Natural polyphenols enhance stability of crosslinked UHMWPE for joint implants. Clin Orthop Relat Res. 2014;473:760–766.
4. Grace MH, Guzman I, Roopchand DE, et al. Stable binding of alternative protein-enriched food matrices with concentrated cranberry bioflavonoids for functional food applications. J Agric Food Chem. 2013;61:6856–6864.
5. Kalim MD, Bhattacharyya D, Banerjee A, Chattopadhyay S. Oxidative DNA damage preventive activity and antioxidant potential of plants used in Unani system of medicine. BMC Complement Altern Med. 2010;10:77.
6. Campos DA, Madureira AR, Gomes AM, Sarmento B, Pintado MM. Optimization of the production of solid Witepsol nanoparticles loaded with rosmarinic acid. Colloids Surf B Biointerfaces. 2014;115:109–117.
7. Madureira AR, Campos DA, Fonte P, et al. Characterization of solid lipid nanoparticles produced with carnauba wax for rosmarinic acid oral delivery. RSC Adv. 2015;5:22665–22673.
8. Campos DA, Madureira AR, Sarmento B, Gomes AM, Pintado MM. Stability of bioactive solid lipid nanoparticles loaded with herbal extracts when exposed to simulated gastrointestinal tract conditions. Food Res Int. 2015;78:131–140.
9. Chiumarelli M, Ferreira MD. Qualidade pós-colheita de tomates’ Débora’com utilização de diferentes coberturas comestíveis e temperaturas de armazenamento. Hortic Bras. 2006;24:381–385.
10. Chiumarelli M, Pereira LM, Ferrari CC, Sarantópoulos CI, Hubinger MD. Cassava starch coating and citric acid to preserve quality parameters of fresh-cut “Tommy Atkins” mango. J Food Sci. 2010;75:E297–E304.
11. Garcia LC, Pereira LM, de Luca Sarantópoulos CI, Hubinger MD. Selection of an edible starch coating for minimally processed strawberry. Food Bioprocess Technol. 2010;3:834–842.
12. da Silva CF, Severino P, Martins F, Chaud MV, Santana MH. The intestinal permeation of didanosine from granules containing microspheres using the everted gut sac model. J Microencapsul. 2009;26:523–528.
13. Gamboa JM, Leong KW. In vitro and in vivo models for the study of oral delivery of nanoparticles. Adv Drug Deliv Rev. 2013;65:800–810.
14. Nunes S, Madureira R, Campos D, et al. Solid lipid nanoparticles as oral delivery systems of phenolic compounds: overcoming pharmacokinetic limitations for nutraceutical applications. Crit Rev Food Sci Nutr. Epub July 20, 2015.
15. Nuñez-Anita RE, Acosta-Torres LS, Vilar-Pineda J, Martínez-Espinosa JC, de la Fuente-Hernández J, Castaño VM. Toxicology of antimicrobial nanoparticles for prosthetic devices. Int J Nanomedicine. 2014;9:3999–4006.
16. Pan CH, Liu WT, Bien MY, et al. Effects of size and surface of zinc oxide and aluminum-doped zinc oxide nanoparticles on cell viability inferred by proteomic analyses. Int J Nanomedicine. 2014;9:3631–3643.
17. Shen WB, Plachez C, Chan A, et al. Human neural progenitor cells retain viability, phenotype, proliferation, and lineage differentiation when labeled with a novel iron oxide nanoparticle, molday ION rhodamine B. Int J Nanomedicine. 2013;8:4593–4600.
18. Zhang XD, Wu D, Shen X, et al. Size-dependent in vivo toxicity of PEG-coated gold nanoparticles. Int J Nanomedicine. 2011;6:2071–2081.
19. De Jong WH, Borm PJ. Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine. 2008;3:133–149.
20. Cui D, Tian F, Ozkan CS, Wang M, Gao H. Effect of single wall carbon nanotubes on human HEK293 cells. Toxicol Lett. 2005;155:73–85.
21. Lin W, Huang YW, Zhou XD, Ma Y. In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol. 2006;217:252–259.
22. Singh N, Manshian B, Jenkins GJ, et al. NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials. 2009;30:3891–3914.
23. Gião MS, González-Sanjosé ML, Muñiz P, et al. Protection of deoxyribose and DNA from degradation by using aqueous extracts of several wild plants. J Sci Food Agric. 2008;88:633–640.
24. Fenech M, Morley AA. Measurement of micronuclei in lymphocytes. Mutat Res. 1985;147:29–36.
25. Eastmond DA, Tucker JD. Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody. Environ Mol Mutagen. 1989;13:34–43.
26. van Engeland M, Ramaekers FC, Schutte B, Reutelingsperger CP. A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture. Cytometry. 1996;24:131–139.
27. Casciola-Rosen L, Rosen A, Petri M, Schlissel M. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1996;93:1624–1629.
28. Piloto N, Teixeira HM, Teixeira-Lemos E, et al. Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping. Cardiovasc Toxicol. 2009;9:201–210.
29. Parada B, Reis F, Figueiredo A, et al. Inhibition of bladder tumour growth by sirolimus in an experimental carcinogenesis model. BJU Int. 2011;107:135–143.
30. Castro-Gómez P, Fontecha J, Rodríguez-Alcalá LM. A high-performance direct transmethylation method for total fatty acids assessment in biological and foodstuff samples. Talanta. 2014;128:518–523.
31. Rodríguez-Alcalá LM, Sá C, Pimentel LL, et al. Endocrine disruptor DDE associated with a high-fat diet enhances the impairment of liver fatty acid composition in rats. J Agric Food Chem. 2015;63:9341–9348.
32. Walch SG, Tinzoh LN, Zimmermann BF, Stuhlinger W, Lachenmeier DW. Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of salvia officinalis L. (sage tea). Front Pharmacol. 2011;2:79.
33. Mi FL, Tan YC, Liang HF, Sung HW. In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials. 2002;23:181–191.
34. El-Zein RA, Schabath MB, Etzel CJ, Lopez MS, Franklin JD, Spitz MR. Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk. Cancer Res. 2006;66:6449–6456.
35. Fenech M. Cytokinesis-block micronucleus cytome assay. Nat Protoc. 2007;2:1084–1104.
36. Kasper D, Zaleznik D. Gas gangrene, antibiotic-associated colitis, and other clostridial infections. Harrisons Princ Intern Med. 2001;1:922–926.
37. Yu SP, Choi DW. Ions, cell volume, and apoptosis. Proc Nat Acad Sci U S A. 2000;97:9360–9362.
38. Baudouin C, Riancho L, Warnet JM, Brignole F. In vitro studies of antiglaucomatous prostaglandin analogues: travoprost with and without benzalkonium chloride and preserved latanoprost. Invest Ophthalmol Vis Sci. 2007;48:4123–4128.
39. Aruoma OI, Spencer JPE, Warren D, Jenner P, Butler J, Halliwell B. Characterization of food antioxidants, illustrated using commercial garlic and ginger preparations. Food Chem. 1997;60:149–156.
40. Konishi Y, Shimizu M. Transepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers. Biosci Biotechnol Biochem. 2003;67:856–862.
41. Konishi Y, Hitomi Y, Yoshida M, Yoshioka E. Pharmacokinetic study of caffeic and rosmarinic acids in rats after oral administration. J Agric Food Chem. 2005;53:4740–4746.
42. Ferraro V, Madureira AR, Fonte P, Sarmento B, Gomes AM, Pintado ME. Evaluation of the interactions between rosmarinic acid and bovine milk casein. RSC Adv. 2015;5:88529–88538.
43. Ferraro V, Madureira AR, Sarmento B, Gomes A, Pintado ME. Study of the interactions between rosmarinic acid and bovine milk whey protein α-lactoalbumin, β-lactoglobulin and lactoferrin. Food Res Int. 2015;77:450–459.
44. Lee HC, Jenner AM, Low CS, Lee YK. Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Res Microbiol. 2006;157:876–884.
45. Greer JB, O’Keefe SK. Microbial induction of immunity, inflammation, and cancer. Front Physiol. 2010;1:168.
46. Scheppach W. Effects of short chain fatty acids on gut morphology and function. Gut. 1994;35:S35–S38.
47. Romo-Vaquero M, Selma MV, Larrosa M, et al. A rosemary extract rich in carnosic acid selectively modulates caecum microbiota and inhibits β-glucosidase activity, altering fiber and short chain fatty acids fecal excretion in lean and obese female rats. PLoS One. 2014;9:e94687.
48. Kishino S, Takeuchi M, Park SB. Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A. 2013;110:17808–17813.