-
1
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang GL, Semenza GL (1995) Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230-1237.
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
2
-
-
0030961006
-
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S, Caro J (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642-22647.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
3
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292:468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
4
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, et al. (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 292:464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
-
5
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, et al. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
-
6
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxiainducible factors for oxygen-dependent proteolysis
-
Maxwell PH, et al. (1999) The tumour suppressor protein VHL targets hypoxiainducible factors for oxygen-dependent proteolysis. Nature 399:271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
-
7
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, et al. (2000) Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2:423-427.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
-
8
-
-
34347227058
-
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
-
DOI 10.1042/BJ20070389
-
Semenza GL (2007) Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem J 405:1-9. (Pubitemid 46999919)
-
(2007)
Biochemical Journal
, vol.405
, Issue.1
, pp. 1-9
-
-
Semenza, G.L.1
-
9
-
-
8344237449
-
Hydroxylation of HIF-1: Oxygen sensing at the molecular level
-
Semenza GL (2004) Hydroxylation of HIF-1: Oxygen sensing at the molecular level. Physiology (Bethesda) 19:176-182.
-
(2004)
Physiology (Bethesda)
, vol.19
, pp. 176-182
-
-
Semenza, G.L.1
-
11
-
-
0028359320
-
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase a genes: Similarities with the erythropoietin 3́ enhancer
-
Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ (1994) Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3́ enhancer. Proc Natl Acad Sci USA 91:6496-6500. (Pubitemid 24984963)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.14
, pp. 6496-6500
-
-
Firth, J.D.1
Ebert, B.L.2
Pugh, C.W.3
Ratcliffe, P.J.4
-
12
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3:187-197.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
13
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
DOI 10.1016/j.cmet.2006.02.002, PII S1550413106000623
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3:177-185. (Pubitemid 43316523)
-
(2006)
Cell Metabolism
, vol.3
, Issue.3
, pp. 177-185
-
-
Kim, J.-W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
14
-
-
38649143118
-
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
-
Aragonés J, et al. (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-180.
-
(2008)
Nat Genet
, vol.40
, pp. 170-180
-
-
Aragonés, J.1
-
15
-
-
33947724515
-
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
-
DOI 10.1016/j.cell.2007.01.047, PII S0092867407003078
-
Fukuda R, et al. (2007) HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129:111-122. (Pubitemid 46507584)
-
(2007)
Cell
, vol.129
, Issue.1
, pp. 111-122
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.-W.3
Shimoda, L.4
Dang, C.V.5
Semenza, G.6
-
16
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
Zhang H, et al. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283:10892-10903.
-
(2008)
J Biol Chem
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
-
17
-
-
0030985635
-
Congenital polycythemia in Chuvashia
-
Sergeyeva A, et al. (1997) Congenital polycythemia in Chuvashia. Blood 89:2148-2154.
-
(1997)
Blood
, vol.89
, pp. 2148-2154
-
-
Sergeyeva, A.1
-
18
-
-
33745756977
-
Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia
-
Bushuev VI, et al. (2006) Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia. Haematologica 91:744-749.
-
(2006)
Haematologica
, vol.91
, pp. 744-749
-
-
Bushuev, V.I.1
-
19
-
-
18744373593
-
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
-
Ang SO, et al. (2002) Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet 32:614-621.
-
(2002)
Nat Genet
, vol.32
, pp. 614-621
-
-
Ang, S.O.1
-
20
-
-
33746398489
-
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
-
Smith TG, et al. (2006) Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med 3:e290.
-
(2006)
PLoS Med
, vol.3
-
-
Smith, T.G.1
-
21
-
-
18944373435
-
Exercise-induced maximal metabolic rate scales with muscle aerobic capacity
-
Weibel ER, Hoppeler H (2005) Exercise-induced maximal metabolic rate scales with muscle aerobic capacity. J Exp Biol 208:1635-1644.
-
(2005)
J Exp Biol
, vol.208
, pp. 1635-1644
-
-
Weibel, E.R.1
Hoppeler, H.2
-
22
-
-
0036549756
-
An acetyl group deficit limits mitochondrial ATP production at the onset of exercise
-
Greenhaff PL, et al. (2002) An acetyl group deficit limits mitochondrial ATP production at the onset of exercise. Biochem Soc Trans 30:275-280.
-
(2002)
Biochem Soc Trans
, vol.30
, pp. 275-280
-
-
Greenhaff, P.L.1
-
23
-
-
1542329757
-
Metabolic inertia in contracting skeletal muscle: A novel approach for pharmacological intervention in peripheral vascular disease
-
Greenhaff PL, et al. (2004) Metabolic inertia in contracting skeletal muscle: A novel approach for pharmacological intervention in peripheral vascular disease. Br J Clin Pharmacol 57:237-243.
-
(2004)
Br J Clin Pharmacol
, vol.57
, pp. 237-243
-
-
Greenhaff, P.L.1
-
24
-
-
0031972736
-
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
-
Bowker-Kinley MM, Davis WI, Wu P, Harris RA, Popov KM (1998) Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J 329:191-196.
-
(1998)
Biochem J
, vol.329
, pp. 191-196
-
-
Bowker-Kinley, M.M.1
Davis, W.I.2
Wu, P.3
Harris, R.A.4
Popov, K.M.5
-
25
-
-
0028851739
-
Diversity of the pyruvate dehydrogenase kinase gene family in humans
-
Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (1995) Diversity of the pyruvate dehydrogenase kinase gene family in humans. J Biol Chem 270:28989-28994.
-
(1995)
J Biol Chem
, vol.270
, pp. 28989-28994
-
-
Gudi, R.1
Bowker-Kinley, M.M.2
Kedishvili, N.Y.3
Zhao, Y.4
Popov, K.M.5
-
26
-
-
36049028935
-
HIF-1alpha in endurance training: Suppression of oxidative metabolism
-
Mason SD, et al. (2007) HIF-1alpha in endurance training: Suppression of oxidative metabolism. Am J Physiol Regul Integr Comp Physiol 293:R2059-R2069.
-
(2007)
Am J Physiol Regul Integr Comp Physiol
, vol.293
-
-
Mason, S.D.1
-
27
-
-
36849013228
-
Von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis
-
Hickey MM, Lam JC, Bezman NA, Rathmell WK, Simon MC (2007) von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J Clin Invest 117:3879-3889.
-
(2007)
J Clin Invest
, vol.117
, pp. 3879-3889
-
-
Hickey, M.M.1
Lam, J.C.2
Bezman, N.A.3
Rathmell, W.K.4
Simon, M.C.5
-
28
-
-
77949725833
-
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
-
Hickey MM, et al. (2010) The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest 120:827-839.
-
(2010)
J Clin Invest
, vol.120
, pp. 827-839
-
-
Hickey, M.M.1
-
29
-
-
0020510630
-
Increased phosphofructokinase content during chronic hypoxia in cultured skeletal muscle (L8) cells
-
DOI 10.1016/0167-4889(83)90040-X
-
Ptashne KA, Theodore J, Robin ED (1983) Increased phosphofructokinase content during chronic hypoxia in cultured skeletal muscle (L8) cells. Biochim Biophys Acta 763:169-174. (Pubitemid 13012208)
-
(1983)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.763
, Issue.2
, pp. 169-174
-
-
Ptashne, K.A.1
Theodore, J.2
Robin, E.D.3
-
30
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza GL, Roth PH, Fang HM, Wang GL (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269:23757-23763.
-
(1994)
J Biol Chem
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
31
-
-
2342550096
-
Allometric scaling of maximal metabolic rate in mammals: Muscle aerobic capacity as determinant factor
-
Weibel ER, Bacigalupe LD, Schmitt B, Hoppeler H (2004) Allometric scaling of maximal metabolic rate in mammals: Muscle aerobic capacity as determinant factor. Respir Physiol Neurobiol 140:115-132.
-
(2004)
Respir Physiol Neurobiol
, vol.140
, pp. 115-132
-
-
Weibel, E.R.1
Bacigalupe, L.D.2
Schmitt, B.3
Hoppeler, H.4
-
32
-
-
8844276053
-
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance
-
Mason SD, et al. (2004) Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol 2:e288.
-
(2004)
PLoS Biol
, vol.2
-
-
Mason, S.D.1
-
33
-
-
0025228821
-
Arteriovenous differences across human adipose and forearm tissues after overnight fast
-
Coppack SW, Frayn KN, Humphreys SM, Whyte PL, Hockaday TD (1990) Arteriovenous differences across human adipose and forearm tissues after overnight fast. Metabolism 39:384-390.
-
(1990)
Metabolism
, vol.39
, pp. 384-390
-
-
Coppack, S.W.1
Frayn, K.N.2
Humphreys, S.M.3
Whyte, P.L.4
Hockaday, T.D.5
-
34
-
-
0025217709
-
Evidence for lactate production by human adipose tissue in vivo
-
Jansson PA, Smith U, Lönnroth P (1990) Evidence for lactate production by human adipose tissue in vivo. Diabetologia 33:253-256. (Pubitemid 20136244)
-
(1990)
Diabetologia
, vol.33
, Issue.4
, pp. 253-256
-
-
Jansson, P.-A.1
Smith, U.2
Lonnroth, P.3
-
35
-
-
0015517384
-
Glucose-lactate inter-relations in man
-
Kreisberg RA (1972) Glucose-lactate inter-relations in man. N Engl J Med 287:132-137.
-
(1972)
N Engl J Med
, vol.287
, pp. 132-137
-
-
Kreisberg, R.A.1
-
36
-
-
0013965807
-
Splanchnic removal of lactate and pyruvate during prolonged exercise in man
-
Rowell LB, et al. (1966) Splanchnic removal of lactate and pyruvate during prolonged exercise in man. J Appl Physiol 21:1773-1783.
-
(1966)
J Appl Physiol
, vol.21
, pp. 1773-1783
-
-
Rowell, L.B.1
-
37
-
-
61749090485
-
Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice
-
Cantley J, et al. (2009) Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest 119:125-135.
-
(2009)
J Clin Invest
, vol.119
, pp. 125-135
-
-
Cantley, J.1
-
38
-
-
61949412026
-
A role for von Hippel-Lindau protein in pancreatic beta-cell function
-
Puri S, Cano DA, Hebrok M (2009) A role for von Hippel-Lindau protein in pancreatic beta-cell function. Diabetes 58:433-441.
-
(2009)
Diabetes
, vol.58
, pp. 433-441
-
-
Puri, S.1
Cano, D.A.2
Hebrok, M.3
-
39
-
-
56549094039
-
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells
-
Zehetner J, et al. (2008) PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev 22:3135-3146.
-
(2008)
Genes Dev
, vol.22
, pp. 3135-3146
-
-
Zehetner, J.1
-
40
-
-
0024148923
-
The lactate paradox: Analysis of underlying mechanisms
-
Hochachka PW (1988) The lactate paradox: Analysis of underlying mechanisms. Annals of Sports Medicine 4:184-188.
-
(1988)
Annals of Sports Medicine
, vol.4
, pp. 184-188
-
-
Hochachka, P.W.1
-
41
-
-
0022900777
-
Lactate during exercise at extreme altitude
-
West JB (1986) Lactate during exercise at extreme altitude. Fed Proc 45:2953-2957.
-
(1986)
Fed Proc
, vol.45
, pp. 2953-2957
-
-
West, J.B.1
-
42
-
-
0026436739
-
Oxygen transport during exercise at altitude and the lactate paradox: Lessons from Operation Everest II and Pikes Peak
-
Reeves JT, et al. (1992) Oxygen transport during exercise at altitude and the lactate paradox: Lessons from Operation Everest II and Pikes Peak. Exerc Sport Sci Rev 20:275-296.
-
(1992)
Exerc Sport Sci Rev
, vol.20
, pp. 275-296
-
-
Reeves, J.T.1
-
43
-
-
34249072139
-
Point: The lactate paradox does/does not occur during exercise at high altitude
-
West JB (2007) Point: The lactate paradox does/does not occur during exercise at high altitude. J Appl Physiol 102:2398-2399.
-
(2007)
J Appl Physiol
, vol.102
, pp. 2398-2399
-
-
West, J.B.1
-
44
-
-
0015407265
-
Control of exercise hyperpnea under varying durations of exposure to moderate hypoxia
-
Dempsey JA, et al. (1972) Control of exercise hyperpnea under varying durations of exposure to moderate hypoxia. Respir Physiol 16:213-231.
-
(1972)
Respir Physiol
, vol.16
, pp. 213-231
-
-
Dempsey, J.A.1
-
46
-
-
34447503842
-
Comments on Point:Counterpoint: "The lactate paradox does/does not occur during exercise at high altitude"
-
author reply 2409-2410
-
Brooks GA (2007) Comments on Point:Counterpoint: "The lactate paradox does/does not occur during exercise at high altitude". J Appl Physiol, 102:2408, author reply 2409-2410.
-
(2007)
J Appl Physiol
, vol.102
, pp. 2408
-
-
Brooks, G.A.1
-
47
-
-
34447498953
-
Comments on Point:Counterpoint: "The lactate paradox does/does not occur during exercise at high altitude"
-
author reply 2409-2410
-
Mazzeo RS (2007) Comments on Point:Counterpoint: "The lactate paradox does/does not occur during exercise at high altitude". J Appl Physiol, 102:2403, author reply 2409-2410.
-
(2007)
J Appl Physiol
, vol.102
, pp. 2403
-
-
Mazzeo, R.S.1
-
48
-
-
35748931469
-
Counterpoint: The lactate paradox does not occur during exercise at high altitude
-
van Hall G (2007) Counterpoint: The lactate paradox does not occur during exercise at high altitude. J Appl Physiol 102:2399-2401.
-
(2007)
J Appl Physiol
, vol.102
, pp. 2399-2401
-
-
Van Hall, G.1
-
49
-
-
61649103127
-
The lactate paradox revisited in lowlanders during acclimatization to 4100 m and in high-altitude natives
-
van Hall G, et al. (2009) The lactate paradox revisited in lowlanders during acclimatization to 4100 m and in high-altitude natives. J Physiol 587:1117-1129.
-
(2009)
J Physiol
, vol.587
, pp. 1117-1129
-
-
Van Hall, G.1
-
50
-
-
0036613379
-
The lactate paradox in human high-altitude physiological performance
-
Hochachka PW, et al. (2002) The lactate paradox in human high-altitude physiological performance. News Physiol Sci 17:122-126.
-
(2002)
News Physiol Sci
, vol.17
, pp. 122-126
-
-
Hochachka, P.W.1
-
51
-
-
34548391772
-
Nonhematological mechanisms of improved sea-level performance after hypoxic exposure
-
Gore CJ, Clark SA, Saunders PU (2007) Nonhematological mechanisms of improved sea-level performance after hypoxic exposure. Med Sci Sports Exerc 39:1600-1609.
-
(2007)
Med Sci Sports Exerc
, vol.39
, pp. 1600-1609
-
-
Gore, C.J.1
Clark, S.A.2
Saunders, P.U.3
-
52
-
-
26444570010
-
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
-
Pollard PJ, et al. (2005) Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 14:2231-2239.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2231-2239
-
-
Pollard, P.J.1
-
53
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
-
Zhao S, et al. (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 324:261-265.
-
(2009)
Science
, vol.324
, pp. 261-265
-
-
Zhao, S.1
-
54
-
-
0042744741
-
Chuvash-type congenital polycythemia in 4 families of Asian and Western European ancestry
-
Percy MJ, et al. (2003) Chuvash-type congenital polycythemia in 4 families of Asian and Western European ancestry. Blood 102:1097-1099.
-
(2003)
Blood
, vol.102
, pp. 1097-1099
-
-
Percy, M.J.1
|