Retraction: Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer (Oncotarget (2016) 7 (53984–53996) DOI: 10.18632/oncotarget.9803);Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer

Oncotarget

Volumn 7, Issue 33, 2016, Pages 53984-53996

  Meng, Erhong ^a,c   Shevde, Lalita A ^a,b   Samant, Rajeev S ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c Beijing Shenogen Biomedical Co Ltd   (China)

Author keywords

Cancer; Chaperone; DNAJB6

Indexed keywords

CALCINEURIN; TRANSCRIPTION FACTOR NFAT; CHAPERONE; DNAJB6 PROTEIN, HUMAN; HEAT SHOCK PROTEIN 40; ISOPROTEIN; NERVE PROTEIN;

BREAST METASTASIS; CARCINOGENESIS; COLORECTAL CANCER; DNA REPLICATION; DNAJB6 GENE; DOWN REGULATION; EMBRYO DEVELOPMENT; EPITHELIAL MESENCHYMAL TRANSITION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEART VENTRICLE HYPERTROPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIMB GIRDLE MUSCULAR DYSTROPHY; MELANOMA; NONHUMAN; PARKINSON DISEASE; REVIEW; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION; GENETICS; METABOLISM; NEOPLASM;

HSP40 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR CHAPERONES; NEOPLASMS; NERVE TISSUE PROTEINS; PROTEIN ISOFORMS;

EID: 84982295428     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.28439     Document Type: Erratum

References (90)

1. Fink AL. Chaperone-mediated protein folding. Physiological reviews. 1999; 79:425-449.
2. Young JC, Agashe VR, Siegers K and Hartl FU. Pathways of chaperone-mediated protein folding in the cytosol. Nature reviews Molecular cell biology. 2004; 5:781-791.
3. Han W and Christen P. Mechanism of the targeting action of DnaJ in the DnaK molecular chaperone system. The Journal of biological chemistry. 2003; 278:19038-19043.
4. Hageman J, van Waarde MA, Zylicz A, Walerych D and Kampinga HH. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. The Biochemical journal. 2011; 435:127-142.
5. Walsh P, Bursac D, Law YC, Cyr D and Lithgow T. The J-protein family: modulating protein assembly, disassembly and translocation. EMBO reports. 2004; 5:567-571.
6. Mitra A, Shevde LA and Samant RS. Multi-faceted role of HSP40 in cancer. Clinical & experimental metastasis. 2009; 26:559-567.
7. Zhang Y, Yang Z, Cao Y, Zhang S, Li H, Huang Y, Ding YQ and Liu X. The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1 nuclear localization which is critical for promotion of cell-cycle arrest in T-cells. The Biochemical journal. 2008; 413:239-250.
8. Sterrenberg JN, Blatch GL and Edkins AL. Human DNAJ in cancer and stem cells. Cancer letters. 2011; 312:129-142.
9. Fan CY, Lee S and Cyr DM. Mechanisms for regulation of Hsp70 function by Hsp40. Cell stress & chaperones. 2003; 8:309-316.
10. De Bock CE, Lin Z, Mekkawy AH, Byrne JA and Wang Y. Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion. International journal of oncology. 2010; 36:1155-1163.
11. Cheng X, Belshan M and Ratner L. Hsp40 facilitates nuclear import of the human immunodeficiency virus type 2 Vpx-mediated preintegration complex. Journal of virology. 2008; 82:1229-1237.
12. Hageman J, Rujano MA, van Waarde MA, Kakkar V, Dirks RP, Govorukhina N, Oosterveld-Hut HM, Lubsen NH and Kampinga HH. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. Molecular cell. 2010; 37:355-369.
13. Sarparanta J, Jonson PH, Golzio C, Sandell S, Luque H, Screen M, McDonald K, Stajich JM, Mahjneh I, Vihola A, Raheem O, Penttila S, Lehtinen S, Huovinen S, Palmio J, Tasca G, et al. Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy. Nature genetics. 2012; 44:450-455, S451-452.
14. Reidy M, Sharma R, Roberts BL and Masison DC. Human J-protein DnaJB6b Cures a Subset of S. cerevisiae Prions and Selectively Blocks Assembly of Structurally Related Amyloids. The Journal of biological chemistry. 2015.
15. Heldens L, Dirks RP, Hensen SM, Onnekink C, van Genesen ST, Rustenburg F and Lubsen NH. Co-chaperones are limiting in a depleted chaperone network. Cell Mol Life Sci. 2010; 67:4035-4048.
16. Winter L and Goldmann WH. Biomechanical characterization of myofibrillar myopathies. Cell Biol Int. 2015; 39:361-363.
17. Chuang JZ, Zhou H, Zhu M, Li SH, Li XJ and Sung CH. Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. The Journal of biological chemistry. 2002; 277:19831-19838.
18. Gillis J, Schipper-Krom S, Juenemann K, Gruber A, Coolen S, van den Nieuwendijk R, van Veen H, Overkleeft H, Goedhart J, Kampinga HH and Reits EA. The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides. The Journal of biological chemistry. 2013; 288:17225-17237.
19. Durrenberger PF, Filiou MD, Moran LB, Michael GJ, Novoselov S, Cheetham ME, Clark P, Pearce RK and Graeber MB. DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes. Journal of neuroscience research. 2009; 87:238-245.
20. Rose JM, Novoselov SS, Robinson PA and Cheetham ME. Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. Hum Mol Genet. 2011; 20:16-27.
21. Ruggieri A, Brancati F, Zanotti S, Maggi L, Pasanisi MB, Saredi S, Terracciano C, Antozzi C, MR DA, Sangiuolo F, Novelli G, Marshall CR, Scherer SW, Morandi L, Federici L, Massa R, et al. Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy. Acta Neuropathol Commun. 2015; 3:44.
22. Harms MB, Sommerville RB, Allred P, Bell S, Ma D, Cooper P, Lopate G, Pestronk A, Weihl CC and Baloh RH. Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy. Annals of neurology. 2012; 71:407-416.
23. Suarez-Cedeno G, Winder T and Milone M. DNAJB6 Myopathy: A vacuolar myopathy with childhood onset. Muscle & nerve. 2013.
24. Couthouis J, Raphael AR, Siskind C, Findlay AR, Buenrostro JD, Greenleaf WJ, Vogel H, Day JW, Flanigan KM and Gitler AD. Exome sequencing identifies a DNAJB6 mutation in a family with dominantly-inherited limb-girdle muscular dystrophy. Neuromuscular disorders: NMD. 2014; 24:431-435.
25. Molkentin JD. Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs. Cardiovascular research. 2004; 63:467-475.
26. Konig A, Fernandez-Zapico ME and Ellenrieder V. Primers on molecular pathways-the NFAT transcription pathway in pancreatic cancer. Pancreatology: official journal of the International Association of Pancreatology. 2010; 10:416-422.
27. Dai YS, Xu J and Molkentin JD. The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Molecular and cellular biology. 2005; 25:9936-9948.
28. Ding Y, Liu W, Deng Y, Jomok B, Yang J, Huang W, Clark KJ, Zhong TP, Lin X, Ekker SC and Xu X. Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening. Circulation research. 2013; 112:606-617.
29. Gomez-Diaz E, Jorda M, Peinado MA and Rivero A. Epigenetics of host-pathogen interactions: the road ahead and the road behind. PLoS pathogens. 2012; 8:e1003007.
30. Taguwa S, Maringer K, Li X, Bernal-Rubio D, Rauch JN, Gestwicki JE, Andino R, Fernandez-Sesma A and Frydman J. Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection. Cell. 2015; 163:1108-1123.
31. Bhowmick R, Li M, Sun J, Baker SA, Insinna C and Besharse JC. Photoreceptor IFT complexes containing chaperones, guanylyl cyclase 1 and rhodopsin. Traffic. 2009; 10:648-663.
32. Hunter PJ, Swanson BJ, Haendel MA, Lyons GE and Cross JC. Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development. Development. 1999; 126:1247-1258.
33. Watson ED, Mattar P, Schuurmans C and Cross JC. Neural stem cell self-renewal requires the Mrj co-chaperone. Developmental dynamics: an official publication of the American Association of Anatomists. 2009; 238:2564-2574.
34. Mitra A, Fillmore RA, Metge BJ, Rajesh M, Xi Y, King J, Ju J, Pannell L, Shevde LA and Samant RS. Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer. Breast cancer research: BCR. 2008; 10:R22.
35. Zhang TT, Jiang YY, Shang L, Shi ZZ, Liang JW, Wang Z, Zhang Y, Hao JJ, Jia XM, Xu X, Cai Y, Zhan QM and Wang MR. Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERKdependent signaling pathway. Molecular carcinogenesis. 2015; 54:1205-1213.
36. Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH and Lung ML. Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells. Gastroenterology. 2015; 149:1825-1836 e1825.
37. Conroy SE and Latchman DS. Do heat shock proteins have a role in breast cancer? Br J Cancer. 1996; 74:717-721.
38. Ischia J and So AI. The role of heat shock proteins in bladder cancer. Nat Rev Urol. 2013; 10:386-395.
39. Lianos GD, Alexiou GA, Mangano A, Mangano A, Rausei S, Boni L, Dionigi G and Roukos DH. The role of heat shock proteins in cancer. Cancer letters. 2015; 360:114-118.
40. Garrido C, Paul C, Seigneuric R and Kampinga HH. The small heat shock proteins family: the long forgotten chaperones. Int J Biochem Cell Biol. 2012; 44:1588-1592.
41. Pennisi R, Ascenzi P and di Masi A. Hsp90: A New Player in DNA Repair? Biomolecules. 2015; 5:2589-2618.
42. Torchy MP, Hamiche A and Klaholz BP. Structure and function insights into the NuRD chromatin remodeling complex. Cell Mol Life Sci. 2015; 72:2491-2507.
43. Gurard-Levin ZA, Quivy JP and Almouzni G. Histone chaperones: assisting histone traffic and nucleosome dynamics. Annu Rev Biochem. 2014; 83:487-517.
44. Keck KM and Pemberton LF. Histone chaperones link histone nuclear import and chromatin assembly. Biochim Biophys Acta. 2013; 1819:277-289.
45. Luo B and Lee AS. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene. 2013; 32:805-818.
46. Avvakumov N, Nourani A and Cote J. Histone chaperones: modulators of chromatin marks. Molecular cell. 2011; 41:502-514.
47. Calderwood SK. Molecular cochaperones: tumor growth and cancer treatment. Scientifica (Cairo). 2013; 2013:217513.
48. Wang X, Chen M, Zhou J and Zhang X. HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review). International journal of oncology. 2014; 45:18-30.
49. Garcia-Carbonero R, Carnero A and Paz-Ares L. Inhibition of HSP90 molecular chaperones: moving into the clinic. Lancet Oncol. 2013; 14:e358-369.
50. Murphy ME. The HSP70 family and cancer. Carcinogenesis. 2013; 34:1181-1188.
51. Siegelin MD. Inhibition of the mitochondrial Hsp90 chaperone network: a novel, efficient treatment strategy for cancer? Cancer letters. 2013; 333:133-146.
52. Tsai MF, Wang CC and Chen JJ. Tumour suppressor HLJ1: A potential diagnostic, preventive and therapeutic target in non-small cell lung cancer. World J Clin Oncol. 2014; 5:865-873.
53. McConnell JR and McAlpine SR. Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets. Bioorg Med Chem Lett. 2013; 23:1923-1928.
54. Yamashita M, Hirohashi Y, Torigoe T, Kusumoto H, Murai A, Imagawa T and Sato N. Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response. PLoS One. 2016; 11:e0146501.
55. Park SY, Choi HK, Seo JS, Yoo JY, Jeong JW, Choi Y, Choi KC and Yoon HG. DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signaling. Biochim Biophys Acta. 2015; 1853:2722-2730.
56. Niu G, Zhang H, Liu D, Chen L, Belani C, Wang HG and Cheng H. Tid1, the Mammalian Homologue of Drosophila Tumor Suppressor Tid56, Mediates Macroautophagy by Interacting with Beclin1-containing Autophagy Protein Complex. The Journal of biological chemistry. 2015; 290:18102-18110.
57. Morita R, Nishizawa S, Torigoe T, Takahashi A, Tamura Y, Tsukahara T, Kanaseki T, Sokolovskaya A, Kochin V, Kondo T, Hashino S, Asaka M, Hara I, Hirohashi Y and Sato N. Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells. Cancer Sci. 2014; 105:389-395.
58. Chen CY, Jan CI, Lo JF, Yang SC, Chang YL, Pan SH, Wang WL, Hong TM and Yang PC. Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR Ubiquitinylation and degradation. Cancer research. 2013; 73:4009-4019.
59. Copeland E, Balgobin S, Lee CM and Rozakis-Adcock M. hTID-1 defines a novel regulator of c-Met Receptor signaling in renal cell carcinomas. Oncogene. 2011; 30:2252-2263.
60. Tsai MF, Wang CC, Chang GC, Chen CY, Chen HY, Cheng CL, Yang YP, Wu CY, Shih FY, Liu CC, Lin HP, Jou YS, Lin SC, Lin CW, Chen WJ, Chan WK, et al. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. J Natl Cancer Inst. 2006; 98:825-838.
61. He HL, Lee YE, Chen HP, Hsing CH, Chang IW, Shiue YL, Lee SW, Hsu CT, Lin LC, Wu TF and Li CF. Overexpression of DNAJC12 predicts poor response to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer. Exp Mol Pathol. 2015; 98:338-345.
62. Mitra A, Menezes ME, Shevde LA and Samant RS. DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype. The Journal of biological chemistry. 2010; 285:24686-24694.
63. Menezes ME, Devine DJ, Shevde LA and Samant RS. Dickkopf1: a tumor suppressor or metastasis promoter? Int J Cancer. 2012; 130:1477-1483.
64. Jeon KW. (2011). International review of cell and molecular biology. Volume 290. (Oxford: Academic).
65. Miller JR and Moon RT. Signal transduction through betacatenin and specification of cell fate during embryogenesis. Genes & development. 1996; 10:2527-2539.
66. Polakis P. Wnt signaling and cancer. Genes & development. 2000; 14:1837-1851.
67. Valenta T, Hausmann G and Basler K. The many faces and functions of beta-catenin. EMBO J. 2012; 31:2714-2736.
68. Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA and Samant RS. DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3beta to downregulate beta-catenin transcription target, osteopontin. Oncogene. 2012; 31:4472-4483.
69. Menezes ME, Mitra A, Shevde LA and Samant RS. DNAJB6 governs a novel regulatory loop determining Wnt/ beta-catenin signalling activity. The Biochemical journal. 2012; 444:573-580.
70. Rao TP and Kuhl M. An updated overview on Wnt signaling pathways: a prelude for more. Circulation research. 2010; 106:1798-1806.
71. Niida A, Hiroko T, Kasai M, Furukawa Y, Nakamura Y, Suzuki Y, Sugano S and Akiyama T. DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/ TCF pathway. Oncogene. 2004; 23:8520-8526.
72. Wodarz A and Nusse R. Mechanisms of Wnt signaling in development. Annual review of cell and developmental biology. 1998; 14:59-88.
73. Micalizzi DS, Farabaugh SM and Ford HL. Epithelialmesenchymal transition in cancer: parallels between normal development and tumor progression. Journal of mammary gland biology and neoplasia. 2010; 15:117-134.
74. Wu ZQ, Li XY, Hu CY, Ford M, Kleer CG and Weiss SJ. Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109:16654-16659.
75. Orford K, Crockett C, Jensen JP, Weissman AM and Byers SW. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. The Journal of biological chemistry. 1997; 272:24735-24738.
76. Ohtsuka K and Hata M. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Cell stress & chaperones. 2000; 5:98-112.
77. Kelley WL. The J-domain family and the recruitment of chaperone power. Trends in biochemical sciences. 1998; 23:222-227.
78. Lin Y, Peng N, Zhuang H, Zhang D, Wang Y and Hua ZC. Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor. BMC Cancer. 2014; 14:639.
79. Izawa I, Nishizawa M, Ohtakara K, Ohtsuka K, Inada H and Inagaki M. Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein. The Journal of biological chemistry. 2000; 275:34521-34527.
80. Watson ED, Geary-Joo C, Hughes M and Cross JC. The Mrj co-chaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta. Development. 2007; 134:1809-1817.
81. Gonias SL, Hembrough TA and Sankovic M. Cytokeratin 8 functions as a major plasminogen receptor in select epithelial and carcinoma cells. Front Biosci. 2001; 6:D1403-1411.
82. Mitra A, Rostas JW, Dyess DL, Shevde LA and Samant RS. Micro-RNA-632 downregulates DNAJB6 in breast cancer. Laboratory investigation; a journal of technical methods and pathology. 2012; 92:1310-1317.
83. Andrews JF, Sykora LJ, Letostak TB, Menezes ME, Mitra A, Barik S, Shevde LA and Samant RS. Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ. Experimental cell research. 2012; 318:1086-1093.
84. Comerford KM, Wallace TJ, Karhausen J, Louis NA, Montalto MC and Colgan SP. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer research. 2002; 62:3387-3394.
85. Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM and Johnson RS. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer research. 2000; 60:4010-4015.
86. Liao D, Corle C, Seagroves TN and Johnson RS. Hypoxiainducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer research. 2007; 67:563-572.
87. Krishnamachary B, Berg-Dixon S, Kelly B, Agani F, Feldser D, Ferreira G, Iyer N, LaRusch J, Pak B, Taghavi P and Semenza GL. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer research. 2003; 63:1138-1143.
88. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW and Giaccia AJ. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 1996; 379:88-91.
89. Watson ED, Hughes M, Simmons DG, Natale DR, Sutherland AE and Cross JC. Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development. Developmental dynamics: an official publication of the American Association of Anatomists. 2011; 240:2505-2519.
90. Dey S, Banerjee P and Saha P. Cell cycle specific expression and nucleolar localization of human J-domain containing co-chaperone Mrj. Molecular and cellular biochemistry. 2009; 322:137-142.