Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR ubiquitinylation and degradation

Cancer Research

Volumn 73, Issue 13, 2013, Pages 4009-4019

  Chen, Chi Yuan ^a   Jan, Chia Ing ^b,i,j   Lo, Jeng Fan ^b,c,d,j   Yang, Shuenn Chen ^e   Chang, Yih Leong ^b   Pan, Szu Hua ^f   Wang, Wen Lung ^e   Hong, Tse Ming ^g,k   Yang, Pan Chyr ^e,g,h  

^a CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b Department of Dentistry ^*  (United States)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^f Graduate Institute of Medical Genomics and Proteomics   (Taiwan)

^g NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^h NATIONAL TAIWAN UNIVERSITY   (Taiwan)

ⁱ CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^j CHINA MEDICAL UNIVERSITY   (Taiwan)

^k NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PROTEIN DNAJ; PROTEIN TID1 L; PROTEIN TID1 S; TANESPIMYCIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; COLONY FORMATION; COMPLEX FORMATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UBIQUITINATION;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; EPIDERMAL GROWTH FACTOR; FEMALE; GENE EXPRESSION; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM TRANSPLANTATION; POLYUBIQUITIN; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 84880069971     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-4066     Document Type: Article

References (26)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin 2008;58: 71-96.
2. Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers-a different disease. Nat Rev Cancer 2007;7: 778-90.
3. Citri A, Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 2006;7: 505-16.
4. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med 2008;359: 1367-80.
5. Weissman AM, Shabek N, Ciechanover A. The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation. Nat Rev Mol Cell Biol 2011;12: 605-20.
6. Pao W, Iafrate AJ, Su Z. Genetically informed lung cancer medicine. J Pathol 2010;223: 230-40.
7. Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer 2005;5: 761-72.
8. Didelot C, Lanneau D, Brunet M, Joly AL, De Thonel A, Chiosis G, et al. Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins. Curr Med Chem 2007;14: 2839-47.
9. Trepel J, Mollapour M, Giaccone G, Neckers L. Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer 2010;10: 537-49.
10. Schilling B, De-Medina T, Syken J, Vidal M, Munger K. A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein. Virology 1998;247: 74-85.
11. Chen CY, Chiou SH, Huang CY, Jan CI, Lin SC, Hu WY, et al. Tid1 functions as a tumour suppressor in head and neck squamous cell carcinoma. J Pathol 2009;219: 347-55.
12. Bae MK, Jeong JW, Kim SH, Kim SY, Kang HJ, Kim DM, et al. Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha. Cancer Res 2005;65: 2520-5.
13. Kim SW, Chao TH, Xiang R, Lo JF, Campbell MJ, Fearns C, et al. Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells. Cancer Res 2004;64: 7732-9.
14. Qiu XB, Shao YM, Miao S, Wang L. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. Cell Mol Life Sci 2006;63: 2560-70.
15. Gaestel M. Molecular chaperones in signal transduction. Handb Exp Pharmacol 2006: 93-109.
16. Jan CI, YuCC, Hung MC, Harn HJ, Nieh S, Lee HS, et al. Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. J Pathol 2011;225: 424-37.
17. Chu YW, Yang PC, Yang SC, Shyu YC, Hendrix MJ, Wu R, et al. Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 1997;17: 353-60.
18. WuYY, Peck K, Chang YL, Pan SH, Cheng YF, Lin JC, et al. SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelialmesenchymal transition in lung cancer. Oncogene 2011;30: 3682-93.
19. Pan SH, Chao YC, Hung PF, Chen HY, Yang SC, Chang YL, et al. The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1. J Clin Invest 2011;121: 3189-205.
20. Lu B, Garrido N, Spelbrink JN, Suzuki CK. Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate. J Biol Chem 2006;281: 13150-8.
21. Banecki B, Liberek K, Wall D, Wawrzynów A, Georgopoulos C, Bertoli E, et al. Structure-function analysis of the zinc finger region of the DnaJ molecular chaperone. J Biol Chem 1996;271: 14840-8.
22. McClellan AJ, Frydman J. Molecular chaperones and the art of recognizing a lost cause. Nat Cell Biol 2001;3: E51-3.
23. Syken J, De-Medina T, Munger K. TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions. Proc Natl Acad Sci U S A 1999;96: 8499-504.
24. Yin X, Rozakis-Adcock M. Genomic organization and expression of the human tumorous imaginal disc (TID1) gene. Gene 2001;278: 201-10.
25. Gallegos Ruiz MI, Floor K, Roepman P, Rodriguez JA, Meijer GA, Mooi WJ, et al. Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. PLoS ONE 2008;3: e0001722.
26. Tsai MF, Wang CC, Chang GC, Chen CY, Chen HY, Cheng CL, et al. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. J Natl Cancer Inst 2006;98: 825-38. Center of Excellence