-
1
-
-
34548416641
-
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
-
Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon SH, Garrido C, Yao TP, Vourc'h C, Matthias P, Khochbin S. 2007. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev 21:2172-2181.
-
(2007)
Genes Dev
, vol.21
, pp. 2172-2181
-
-
Boyault, C.1
Zhang, Y.2
Fritah, S.3
Caron, C.4
Gilquin, B.5
Kwon, S.H.6
Garrido, C.7
Yao, T.P.8
Vourc'h, C.9
Matthias, P.10
Khochbin, S.11
-
2
-
-
34547727312
-
Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease
-
Braak H, Sastre M, Del Tredici K. 2007. Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol 114:231-241.
-
(2007)
Acta Neuropathol
, vol.114
, pp. 231-241
-
-
Braak, H.1
Sastre, M.2
Del Tredici, K.3
-
3
-
-
0026696593
-
Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons
-
Cheetham ME, Brion JP, Anderton BH. 1992. Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons. Biochem J 284:469-476.
-
(1992)
Biochem J
, vol.284
, pp. 469-476
-
-
Cheetham, M.E.1
Brion, J.P.2
Anderton, B.H.3
-
4
-
-
0037205425
-
Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently
-
Chuang JZ, Zhou H, Zhu M, Li SH, Li XJ, Sung CH. 2002., Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. J Biol Chem 277:19831-19838.
-
(2002)
J Biol Chem
, vol.277
, pp. 19831-19838
-
-
Chuang, J.Z.1
Zhou, H.2
Zhu, M.3
Li, S.H.4
Li, X.J.5
Sung, C.H.6
-
5
-
-
27644521346
-
The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment
-
Dai YS, Xu J, Molkentin JD. 2005. The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol 25:9936-9948.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 9936-9948
-
-
Dai, Y.S.1
Xu, J.2
Molkentin, J.D.3
-
6
-
-
33746104816
-
Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease
-
Duke DC, Moran LB, Kalaitzakis ME, Deprez M, Dexter DT, Pearce RK, Graeber MB. 2006. Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease. Neurogenetics 7:139-148.
-
(2006)
Neurogenetics
, vol.7
, pp. 139-148
-
-
Duke, D.C.1
Moran, L.B.2
Kalaitzakis, M.E.3
Deprez, M.4
Dexter, D.T.5
Pearce, R.K.6
Graeber, M.B.7
-
7
-
-
33750015475
-
A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation
-
Fayazi Z, Ghosh S, Marion S, Bao X, Shero M, Kazemi-Esfarjani P. 2006. A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation. Neurobiol Dis 24:226-244.
-
(2006)
Neurobiol Dis
, vol.24
, pp. 226-244
-
-
Fayazi, Z.1
Ghosh, S.2
Marion, S.3
Bao, X.4
Shero, M.5
Kazemi-Esfarjani, P.6
-
8
-
-
12944250987
-
Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
-
Hartmann A, Hunot S, Michel PP, Muriel MP, Vyas S, Faucheux BA, Mouatt-Prigent A, Turmel H, Srinivasan A, Ruberg M, Evan GI, Agid Y, Hirsch EC. 2000. Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc Natl Acad Sci U S A 97:2875-2880.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 2875-2880
-
-
Hartmann, A.1
Hunot, S.2
Michel, P.P.3
Muriel, M.P.4
Vyas, S.5
Faucheux, B.A.6
Mouatt-Prigent, A.7
Turmel, H.8
Srinivasan, A.9
Ruberg, M.10
Evan, G.I.11
Agid, Y.12
Hirsch, E.C.13
-
9
-
-
14144251429
-
Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis
-
Jayanthi S, Deng X, Ladenheim B, McCoy MT, Cluster A, Cai NS, Cadet JL. 2005. Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis. Proc Natl Acad Sci U S A 102:868-873.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 868-873
-
-
Jayanthi, S.1
Deng, X.2
Ladenheim, B.3
McCoy, M.T.4
Cluster, A.5
Cai, N.S.6
Cadet, J.L.7
-
10
-
-
0346020435
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
-
Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP. 2003. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115:727-738.
-
(2003)
Cell
, vol.115
, pp. 727-738
-
-
Kawaguchi, Y.1
Kovacs, J.J.2
McLaurin, A.3
Vance, J.M.4
Ito, A.5
Yao, T.P.6
-
11
-
-
2942620074
-
Hsp70 reduces alpha-synuclein aggregation and toxicity
-
Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ. 2004. Hsp70 reduces alpha-synuclein aggregation and toxicity. J Biol Chem 279: 25497-25502.
-
(2004)
J Biol Chem
, vol.279
, pp. 25497-25502
-
-
Klucken, J.1
Shin, Y.2
Masliah, E.3
Hyman, B.T.4
McLean, P.J.5
-
12
-
-
33749583553
-
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
-
Kontopoulos E, Parvin JD, Feany MB. 2006. Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet 15:3012-3023.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 3012-3023
-
-
Kontopoulos, E.1
Parvin, J.D.2
Feany, M.B.3
-
13
-
-
0023931333
-
Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study
-
Kuzuhara S, Mori H, Izumiyama N, Yoshimura M, Ihara Y. 1988. Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta Neuropathol 75:345-353.
-
(1988)
Acta Neuropathol
, vol.75
, pp. 345-353
-
-
Kuzuhara, S.1
Mori, H.2
Izumiyama, N.3
Yoshimura, M.4
Ihara, Y.5
-
14
-
-
40749094842
-
Origins and effects of extracellular alpha-synuclein: Implications in Parkinson's disease
-
Lee SJ. 2008. Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease. J Mol Neurosci 34:17-22.
-
(2008)
J Mol Neurosci
, vol.34
, pp. 17-22
-
-
Lee, S.J.1
-
15
-
-
23644443643
-
Gene expression profiling of Lewy body-bearing neurons in Parkinson's disease
-
Lu L, Neff F, Alvarez-Fischer D, Henze C, Xie Y, Oertel WH, Schlegel J, Hartmann A. 2005. Gene expression profiling of Lewy body-bearing neurons in Parkinson's disease. Exp Neurol 195:27-39.
-
(2005)
Exp Neurol
, vol.195
, pp. 27-39
-
-
Lu, L.1
Neff, F.2
Alvarez-Fischer, D.3
Henze, C.4
Xie, Y.5
Oertel, W.H.6
Schlegel, J.7
Hartmann, A.8
-
16
-
-
0030776204
-
Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord
-
Michael GJ, Averill S, Nitkunan A, Rattray M, Bennett DL, Yan Q, Priestley JV. 1997. Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord. J Neurosci 17:8476-8490.
-
(1997)
J Neurosci
, vol.17
, pp. 8476-8490
-
-
Michael, G.J.1
Averill, S.2
Nitkunan, A.3
Rattray, M.4
Bennett, D.L.5
Yan, Q.6
Priestley, J.V.7
-
17
-
-
0032738677
-
The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease
-
Mirza B, Hadberg H, Thomsen P, Moos T. 2000. The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease. Neuroscience 95:425-432.
-
(2000)
Neuroscience
, vol.95
, pp. 425-432
-
-
Mirza, B.1
Hadberg, H.2
Thomsen, P.3
Moos, T.4
-
18
-
-
38649121744
-
Towards a pathway definition of Parkinson's disease: A complex disorder with links to cancer, diabetes and inflammation
-
Moran LB, Graeber MB. 2008. Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation. Neurogenetics 9:1-13.
-
(2008)
Neurogenetics
, vol.9
, pp. 1-13
-
-
Moran, L.B.1
Graeber, M.B.2
-
19
-
-
33644658492
-
Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease
-
Moran LB, Duke DC, Deprez M, Dexter DT, Pearce RK, Graeber MB. 2006. Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease. Neurogenetics 7:1-11.
-
(2006)
Neurogenetics
, vol.7
, pp. 1-11
-
-
Moran, L.B.1
Duke, D.C.2
Deprez, M.3
Dexter, D.T.4
Pearce, R.K.5
Graeber, M.B.6
-
20
-
-
41149121201
-
Neuronal pentraxin II is highly up-regulated in Parkinson's disease and a novel component of Lewy bodies
-
Moran LB, Hickey E, Michael GJ, Derkacs M, Christian LM, Kalaitzakis ME, Pearce RK, Graeber MB. 2008. Neuronal pentraxin II is highly up-regulated in Parkinson's disease and a novel component of Lewy bodies. Acta Neuropathol 115:471-478.
-
(2008)
Acta Neuropathol
, vol.115
, pp. 471-478
-
-
Moran, L.B.1
Hickey, E.2
Michael, G.J.3
Derkacs, M.4
Christian, L.M.5
Kalaitzakis, M.E.6
Pearce, R.K.7
Graeber, M.B.8
-
22
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. 2007. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447:859-863.
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
Nedelsky, N.B.6
Schwartz, S.L.7
DiProspero, N.A.8
Knight, M.A.9
Schuldiner, O.10
Padmanabhan, R.11
Hild, M.12
Berry, D.L.13
Garza, D.14
Hubbert, C.C.15
Yao, T.P.16
Baehrecke, E.H.17
Taylor, J.P.18
-
23
-
-
0242317675
-
Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis
-
Peirson SN, Butler JN, Foster RG. 2003. Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res 31:e73.
-
(2003)
Nucleic Acids Res
, vol.31
-
-
Peirson, S.N.1
Butler, J.N.2
Foster, R.G.3
-
24
-
-
33751265748
-
The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones
-
Qiu XB, Shao YM, Miao S, Wang L. 2006. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. Cell Mol Life Sci 63:2560-2570.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 2560-2570
-
-
Qiu, X.B.1
Shao, Y.M.2
Miao, S.3
Wang, L.4
-
25
-
-
34547126694
-
-
Rochet JC. Novel therapeutic strategies for the treatment of protein-misfolding diseases. 2007. Expert Rev Mol Med 9:1-34.
-
Rochet JC. Novel therapeutic strategies for the treatment of protein-misfolding diseases. 2007. Expert Rev Mol Med 9:1-34.
-
-
-
-
27
-
-
0032568534
-
Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
-
Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. 1998. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci U S A 95:6469-6473.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
28
-
-
33748751765
-
Histone deacetylase (HDAC) 4 involvement in both Lewy and Marinesco bodies
-
Takahashi-Fujigasaki J, Fujigasaki H. 2006. Histone deacetylase (HDAC) 4 involvement in both Lewy and Marinesco bodies. Neuropathol Appl Neurobiol 32:562-566.
-
(2006)
Neuropathol Appl Neurobiol
, vol.32
, pp. 562-566
-
-
Takahashi-Fujigasaki, J.1
Fujigasaki, H.2
-
29
-
-
0037313281
-
Glial involvement in diffuse Lewy body disease
-
Terada S, Ishizu H, Yokota O, Tsuchiya K, Nakashima H, Ishihara T, Fujita D, Ueda K, Ikeda K, Kuroda S. 2003. Glial involvement in diffuse Lewy body disease. Acta Neuropathol 105:163-169.
-
(2003)
Acta Neuropathol
, vol.105
, pp. 163-169
-
-
Terada, S.1
Ishizu, H.2
Yokota, O.3
Tsuchiya, K.4
Nakashima, H.5
Ishihara, T.6
Fujita, D.7
Ueda, K.8
Ikeda, K.9
Kuroda, S.10
-
30
-
-
0033973421
-
NACP/ alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains
-
Wakabayashi K, Hayashi S, Yoshimoto M, Kudo H, Takahashi H. 2000. NACP/ alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains. Acta Neuropathol 99: 14-20.
-
(2000)
Acta Neuropathol
, vol.99
, pp. 14-20
-
-
Wakabayashi, K.1
Hayashi, S.2
Yoshimoto, M.3
Kudo, H.4
Takahashi, H.5
-
31
-
-
34249059782
-
The Mrj cochaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta
-
Watson ED, Geary-Joo C, Hughes M, Cross JC. 2007. The Mrj cochaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta. Development 134:1809-1817.
-
(2007)
Development
, vol.134
, pp. 1809-1817
-
-
Watson, E.D.1
Geary-Joo, C.2
Hughes, M.3
Cross, J.C.4
-
32
-
-
20144366969
-
HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients, to the proteasome
-
Westhoff B, Chapple JP, van der Spuy J, Hohfeld J, Cheetham ME. 2005. HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients, to the proteasome. Curr Biol 15:1058-1064.
-
(2005)
Curr Biol
, vol.15
, pp. 1058-1064
-
-
Westhoff, B.1
Chapple, J.P.2
van der Spuy, J.3
Hohfeld, J.4
Cheetham, M.E.5
|