Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma

Journal of Hepato-Biliary-Pancreatic Sciences

Volumn 23, Issue 8, 2016, Pages 467-471

  Shimizu, Takayuki ^a   Inoue, Ken Ichi ^a   Hachiya, Hiroyuki ^a   Shibuya, Norisuke ^a   Aoki, Taku ^a   Kubota, Keiichi ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Hepatocellular carcinoma; NF E2 related factor 2; p62; Pentose phosphate pathway; Selective autophagy

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEIN P62; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LIVER CELL CARCINOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS;

EID: 84982279728     PISSN: 18686974     EISSN: 18686982     Source Type: Journal    
DOI: 10.1002/jhbp.364     Document Type: Article

References (27)

1. Warburg O. On the origin of cancer cells. Science. 1956; 123:309–14.
2. Shimizu T, Inoue K, Hachiya H, Shibuya N, Shimoda M, Kubota K. Frequent alteration of the protein synthesis of enzymes for glucose metabolism in hepatocellular carcinomas. J Gastroenterol. 2014;49:1324–32.
3. Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, et al. An nrf2/small maf heterodimer mediates the induction of phase ii detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997;236:313–22.
4. Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, et al. Keap1-null mutation leads to postnatal lethality due to constitutive nrf2 activation. Nat Genet. 2003;35:238–45.
5. Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, et al. Oxidative stress sensor keap1 functions as an adaptor for cul3-based e3 ligase to regulate proteasomal degradation of nrf2. Mol Cell Biol 2004;24:7130–9.
6. Taguchi K, Motohashi H, Yamamoto M. Molecular mechanisms of the keap1-nrf2 pathway in stress response and cancer evolution. Genes Cells: devoted to molecular & cellular mechanisms. 2011;16:123–40.
7. Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell. 2012;22:66–79.
8. Tanito M, Agbaga MP, Anderson RE. Upregulation of thioredoxin system via nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro. Free Radic Biol Med. 2007;42:1838–50.
9. Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, et al. Dysfunctional keap1-nrf2 interaction in non-small-cell lung cancer. PLoS Med. 2006;3:e420.
10. Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, et al. Genetic alteration of keap1 confers constitutive nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology. 2008;135:1358–68, 1368 e1351-4.
11. Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W, et al. High levels of nrf2 determine chemoresistance in type ii endometrial cancer. Cancer Res. 2010;70:5486–96.
12. Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet. 2012;44:694–8.
13. Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, et al. Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer. Mol Cell. 2006;21:689–700.
14. Wang R, An J, Ji F, Jiao H, Sun H, Zhou D. Hypermethylation of the keap1 gene in human lung cancer cell lines and lung cancer tissues. Biochem Biophys Res Commun. 2008;373:151–4.
15. Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, et al. Phosphorylation of p62 activates the keap1-nrf2 pathway during selective autophagy. Mol Cell. 2013;51:618–31.
16. Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the keap1-nrf2-are pathway. Annu Rev Pharmacol Toxicol. 2007;47:89–116.
17. Rubinsztein DC, Marino G, Kroemer G. Autophagy and aging. Cell. 2011;146:682–695.
18. Sporn MB, Liby KT. Nrf2 and cancer: The good, the bad and the importance of context. Nat Rev Cancer. 2012;12:564–71.
19. White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer. 2012;12:401–10.
20. Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, et al. Cancer related mutations in nrf2 impair its recognition by keap1-cul3 e3 ligase and promote malignancy. Proc Natl Acad Sci U S A. 2008;105:13568–73.
21. Adam J, Hatipoglu E, O'Flaherty L, Ternette N, Sahgal N, Lockstone H, et al. Renal cyst formation in fh1-deficient mice is independent of the hif/phd pathway: Roles for fumarate in keap1 succination and nrf2 signaling. Cancer Cell. 2011;20:524–37.
22. Srinivasan R, Ricketts CJ, Sourbier C, Linehan WM. New strategies in renal cell carcinoma: Targeting the genetic and metabolic basis of disease. Clin Canc Res: an official journal of the American Association for Cancer Research. 2015;21:10–17.
23. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008;451:1069–75.
24. Deretic V, Levine B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe. 2009;5:527–49.
25. Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell. 2009;34:259–69.
26. Youle RJ, Narendra DP. Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 2011;12:9–14.
27. Weidberg H, Shvets E, Elazar Z. Biogenesis and cargo selectivity of autophagosomes. Annu Rev Biochem. 2011;80:125–56.