How much can the tubule regenerate and who does it? An open question

Nephrology Dialysis Transplantation

Volumn 31, Issue 8, 2016, Pages 1243-1250

  Lombardi, Duccio ^a   Becherucci, Francesca ^b   Romagnani, Paola ^a,b,c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

AKI; Stem cell; Tubular cell dedifferentiation; Tubular progenitor; Tubular regeneration

Indexed keywords

ACUTE KIDNEY FAILURE; CELL CYCLE REGULATION; CELL DEATH; CELL DIFFERENTIATION; CELL DIVISION; CELL LINEAGE; CELL REGENERATION; FUNCTIONAL ASSESSMENT; HUMAN; KIDNEY TUBULE; KIDNEY TUBULE CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEM CELL; TISSUE REGENERATION; ACUTE KIDNEY INJURY; ANIMAL; CYTOLOGY; PHYSIOLOGY; REGENERATION;

ACUTE KIDNEY INJURY; ANIMALS; HUMANS; KIDNEY TUBULES; REGENERATION; STEM CELLS;

EID: 84982126191     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfv262     Document Type: Review

References (50)

1. Uchino S, Kellum JA, Bellomo R et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005; 294: 813-818
2. Basile DP, Anderson MD, Sutton TA. Pathophysiology of acute kidney injury. Compr Physiol 2012; 2: 1303-1353
3. James MT, Ghali WA, Tonelli M et al. Acute kidney injury following coronary angiography is associated with a long-term decline in kidney function. Kidney Int 2010; 78: 803-809
4. Coca SG, Singanamala S, Parikh CR. Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int 2012; 81: 442-448
5. Lo LJ, Go AS, Chertow GM et al. Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int 2009; 76: 893-899
6. Rydén L, Sartipy U, EvansMet al. Acute kidney injury after coronary artery bypass grafting and long-term risk of end-stage renal disease. Circulation 2014; 130: 2005-2011
7. James MT, GhaliWA, Knudtson ML et al. Associations between acute kidney injury and cardiovascular and renal outcomes after coronary angiography. Circulation 2011; 123: 409-416
8. Ibrahim HN, Foley R, Tan L et al. Long-term consequences of kidney donation. N Engl J Med 2009; 360: 459-469
9. Humphreys BD, Valerius MT, Kobayashi A et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008; 2: 284-291
10. Kobayashi A, Valerius MT, Mugford JW et al. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 2008; 3: 169-181
11. Vogetseder A, Picard N, Gaspert A et al
12. Angelotti ML, Ronconi E, Ballerini L et al. Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury. Stem Cells 2012; 30: 1714-1725
13. Kitamura S, Yamasaki Y, Kinomura M et al. Establishment and characterization of renal progenitor like cells from S3 segment of nephron in rat adult kidney. FASEB J 2005; 19: 1789-1797
14. Maeshima A, Yamashita S, Nojima Y. Identification of renal progenitor-like tubular cells that participate in the regeneration processes of the kidney. J Am Soc Nephrol 2003; 14: 3138-3146
15. Romagnani P, Remuzzi G. Renal progenitors in non-diabetic and diabetic nephropathies. Trends Endocrinol Metab 2013; 24: 13-20
16. Romagnani P, Lasagni L, Remuzzi G. Renal progenitors: an evolutionary conserved strategy for kidney regeneration. Nat Rev Nephrol 2013; 9: 137-146
17. Sagrinati C, Netti GS, Mazzinghi B et al. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. Am Soc Nephrol 2006; 17: 2443-2456
18. Ronconi E, Sagrinati C, Angelotti ML et al. Regeneration of glomerular podocytes by human renal progenitors. J AmSoc Nephrol 2009; 20: 322-332
19. Lindgren D, Boström AK, Nilsson K et al. Isolation and characterization of progenitor-like cells from human renal proximal tubules. Am J Pathol 2011; 178: 828-837
20. Smeets B, Boor P, Dijkman H et al. Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration. J Pathol 2013; 229: 645-659
21. Bussolati B, Bruno S, Grange C et al. Isolation of renal progenitor cells from adult human kidney. Am J Pathol 2005; 166: 545-555
22. Berger K, Bangen JM, Hammerich L et al. Origin of regenerating tubular cells after acute kidney injury. Proc Natl Acad Sci USA 2014; 111: 1533-1538
23. Kusaba T, Lalli M, Kramann R et al. Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci USA 2014; 111: 1527-1532
24. Humphreys BD, Czerniak S, DiRocco DP et al. Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci USA 2011; 108: 9226-9231
25. Romagnani P, Rinkevich Y, Dekel B. The use of lineage tracing to study kidney injury and regeneration. Nat Rev Nephrol 2015. doi:10. 1038/nrneph. 2015. 67
26. Kramann R, Kusaba T, Humphreys BD. Who regenerates the kidney tubule? Nephrol Dial Transplant 2016; 30: 903-910
27. Barker N, van Es JH, Kuipers J et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449: 1003-1007
28. Rios AC, Fu NY, Lindeman GJ et al. In situ identification of bipotent stem cells in the mammary gland. Nature 2014; 506: 322-327
29. Barker N, Rookmaaker MB, Kujala P et al. Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Rep 2012; 2: 540-552
30. Lombardi D, Lasagni L. Transgenic strategies to study podocyte loss and regeneration. Stem Cells Int 2015; doi:10. 1155/2015/678347
31. Appel D, Kershaw DB, Smeets B et al. Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 2009; 20: 333-343
32. Ousset M, Van Keymeulen A, Bouvencourt G et al. Multipotent and unipotent progenitors contribute to prostate postnatal development. Nat Cell Biol 2012; 14: 1131-1138
33. Mascré G, Dekoninck S, Drogat B et al. Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature 2012; 489: 257-262
34. Pina C, Fugazza C, Tipping AJ et al. Inferring rules of lineage commitment in haematopoiesis. Nat Cell Biol 2012; 14: 287-294
35. Jensen P, Farago AF, Awatramani RB et al. Redefining the serotonergic system by genetic lineage. Nat Neurosci 2008; 11: 417-419
36. Hsu YC, Li L, Fuchs E. Transit-amplifying cells orchestrate stem cell activity and tissue regeneration. Cell 2014; 157: 935-949
37. Grosse-Gehling P, Fargeas CA, Dittfeld C et al. CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges. J Pathol 2013; 229: 355-378
38. Hansson J, Hultenby K, Cramnert C et al. Evidence for a morphologically distinct and functionally robust cell type in the proximal tubules of human kidney. Hum Pathol 2014; 45: 382-393
39. Langworthy M, Zhou B, de Caestecker M et al. NFATc1 identifies a population of proximal tubule cell progenitors. J Am Soc Nephrol 2009; 20: 311-321
40. Axelson H, Johansson ME. Renal stem cells and their implications for kidney cancer. Semin Cancer Biol 2013; 23: 56-61
41. Nonclercq D,Wrona S, ToubeauG et al. Tubular injury and regeneration in the rat kidney following acute exposure to gentamicin: a time-course study. Ren Fail 1992; 14: 507-521
42. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182: 311-322
43. Wang F, Higgins JM. Histone modifications and mitosis: countermarks, landmarks, and bookmarks. Trends Cell Biol 2013; 23: 175-184
44. Iatropoulos MJ, Williams GM. Proliferation markers. Exp Toxicol Pathol 1996; 48: 175-181
45. Nguan CY, Guan Q, Gleave ME et al. Promotion of cell proliferation by clusterin in the renal tissue repair phase after ischemia-reperfusion injury. Am J Physiol Renal Physiol 2014; 306: F724-F733
46. Ye Y, Wang B, Jiang X et al. Proliferative capacity of stem/progenitor-like cells in the kidney may associate with the outcome of patients with acute tubular necrosis. Hum Pathol 2011; 42: 1132-1141
47. Thomasova D, Anders HJ. Cell cycle control in the kidney. Nephrol Dial Transplant 2016; 30: 1622-1630
48. Miyaoka Y, Ebato K, Kato H et al. Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration. Curr Biol 2012; 22: 1166-1175
49. Cuppage FE, Tate A. Repair of the nephron following injury with mercuric chloride. Am J Pathol 1967; 51: 405-429
50. Rinkevich Y, MontoroDT, Contreras-TrujilloHet al. In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Rep 2014; 7: 1270-1283