Intracellular accumulation of Praziquantel in T lymphoblastoid cell lines, CEM (parental) and CEMvbl(P-gp-overexpressing)

BMC Pharmacology and Toxicology

Volumn 17, Issue 1, 2016, Pages

  Kigen, Gabriel ^a,b   Edwards, Geoffrey ^b  

^a MOI UNIVERSITY   (Kenya)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Characterization; P glycoprotein; Pharmacokinetics; Praziquantel

Indexed keywords

AMMONIUM FORMATE; CLOZAPINE; MULTIDRUG RESISTANCE PROTEIN; PRAZIQUANTEL; SAQUINAVIR; TARIQUIDAR;

ARTICLE; CALIBRATION; CELL CULTURE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STABILITY; ELUTION; ENZYME SPECIFICITY; FLOW RATE; HUMAN; HUMAN CELL; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; LYMPHOBLASTOID CELL LINE; PROTEIN EXPRESSION; REVERSED PHASE LIQUID CHROMATOGRAPHY; SUPERNATANT; T LYMPHOCYTE; BIOSYNTHESIS; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; EXTRACELLULAR FLUID; INTRACELLULAR FLUID; METABOLISM;

CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR FLUID; HUMANS; INTRACELLULAR FLUID; P-GLYCOPROTEIN; PRAZIQUANTEL; T-LYMPHOCYTES;

EID: 84981747436     PISSN: None     EISSN: 20506511     Source Type: Journal    
DOI: 10.1186/s40360-016-0079-4     Document Type: Article

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