Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility

Molecular and Biochemical Parasitology

Volumn 167, Issue 1, 2009, Pages 54-59

  Messerli, Shanta M ^a   Kasinathan, Ravi S ^b   Morgan, William ^b   Spranger, Stefani ^c   Greenberg, Robert M ^b  

^a MARINE BIOLOGICAL LABORATORY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

ABC transporter; Multidrug resistance; P glycoprotein; Praziquantel; Schistosoma mansoni

Indexed keywords

GLYCOPROTEIN P; PRAZIQUANTEL; ANTHELMINTIC AGENT; HELMINTH PROTEIN;

ARTICLE; CONCENTRATION PROCESS; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; IMMUNOREACTIVITY; MULTIDRUG RESISTANCE; NONHUMAN; PARASITE ISOLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SEQUENCE HOMOLOGY; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; DRUG RESISTANCE; EGYPT; GENE EXPRESSION PROFILING; HUMAN; ISOLATION AND PURIFICATION; MALE; MOUSE; PARASITOLOGY; SCHISTOSOMIASIS MANSONI;

SCHISTOSOMA MANSONI; VERMES; VERTEBRATA;

ANIMALS; ANTHELMINTICS; DRUG RESISTANCE; EGYPT; FEMALE; GENE EXPRESSION PROFILING; HELMINTH PROTEINS; HUMANS; MALE; MICE; P-GLYCOPROTEIN; PRAZIQUANTEL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI;

EID: 67650373884     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2009.04.007     Document Type: Article

References (40)

1. Greenberg R.M. Praziquantel: mechanism of action. In: Maule A., and Marks N.J. (Eds). Parasitic flatworms: molecular biology, biochemistry, immunology and physiology (2006), CAB International, Oxfordshire, UK 269-281
2. 2+ channels targets of praziquantel action?. Int J Parasitol 35 (2005) 1-9
3. Cioli D., and Pica-Mattoccia L. Praziquantel. Parasitol Res 90 Suppl 1 (2003) S3-S9
4. Andrews P. Praziquantel: mechanisms of antischistosomal activity. Pharmacol Ther 29 (1985) 129-156
5. Fenwick A., Savioli L., Engels D., et al. Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends Parasitol 19 (2003) 509-515
6. Hagan P., Appleton C.C., Coles G.C., et al. Schistosomiasis control: keep taking the tablets. Trends Parasitol 20 (2004) 92-97
7. Day T.A., and Botros S. Drug resistance in schistosomes. In: Maule A., and Marks N.J. (Eds). Parasitic flatworms: molecular biology, biochemistry, immunology and physiology (2006), CAB International, Oxfordshire, UK 256-268
8. Ambudkar S.V., Kimchi-Sarfaty C., Sauna Z.E., and Gottesman M.M. P-glycoprote: from genomics to F mechanism. Oncogene 22 (2003) 7468-7485
9. Leonard G.D., Fojo T., and Bates S.E. The role of ABC transporters in clinical practice. The Oncologist 8 (2003) 411-424
10. Lin J.H., and Yamazaki M. Clinical relevance of P-glycoprotein in drug therapy. Drug Metab Rev 35 (2003) 417-454
11. Paulsen I.T. Multidrug efflux pumps and resistance: regulation and evolution. Curr Opin Microbiol 6 (2003) 446-451
12. Blackhall W.J., Liu H.Y., Xu M., et al. Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus. Mol Biochem Parasitol 95 (1998) 193-201
13. Xu M., Molento M., Blackhall W., et al. Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog. Mol Biochem Parasitol 91 (1998) 327-335
14. Sangster N.C., Bannan S.C., Weiss A.S., et al. Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins and an association with avermectin/milbemycin resistance. Exp Parasitol 91 (1999) 250-257
15. Smith J.M., and Prichard R.K. Localization of p-glycoprotein mRNA in the tissues of Haemonchus contortus adult worms and its relative abundance in drug-selected and susceptible strains. J Parasitol 88 (2002) 612-620
16. Prichard R.K., and Roulet A. ABC transporters and beta-tubulin in macrocyclic lactone resistance: prospects for marker development. Parasitology 134 (2007) 1123-1132
17. Blackhall W.J., Prichard R.K., and Beech R.N. P-glycoprotein selection in strains of Haemonchus contortus resistant to benzimidazoles. Vet Parasitol 152 (2008) 101-107
18. Bourguinat C., Ardelli B.F., Pion S.D., et al. P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus. Mol Biochem Parasitol 158 (2008) 101-111
19. Kerboeuf D., Blackhall W., Kaminsky R., and von Samson-Himmelstjerna G. P-glycoprotein in helminths: function and perspectives for anthelmintic treatment and reversal of resistance. Int J Antimicrob Agents 22 (2003) 332-346
20. Jones P.M., and George A.M. Multidrug resistance in parasites: ABC transporters, P-glycoproteins and molecular modelling. Int J Parasitol 35 (2005) 555-566
21. Lespine A., Alvinerie M., Vercruysse J., Prichard R.K., and Geldhof P. ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics. Trends Parasitol 24 (2008) 293-298
22. Bosch I.B., Wang Z.-X., Tao L.-F., and Shoemaker C.B. Two Schistosoma mansoni cDNAs encoding ATP-binding cassette (ABC) family proteins. Mol Biochem Parasitol 65 (1994) 351-356
23. Reed M.B., Panaccio M., Strugnell R.A., and Spithill T.W. Developmental expression of a Fasciola hepatica sequence homologous to ABC transporters. Int J Parasitol 28 (1998) 1375-1381
24. Sato H., Kusel J.R., and Thornhill J. Functional visualization of the excretory system of adult Schistosoma mansoni by the fluorescent marker resorufin. Parasitology 125 (2002) 527-535
25. Sato H., Kusel J.R., and Thornhill J. Excretion of fluorescent substrates of mammalian multidrug resistance-associated protein (MRP) in the Schistosoma mansoni excretory system. Parasitology 128 (2004) 43-52
26. Oliviera F.A., Kusel J.R., Ribeiro F., and Coelho P.M.Z. Responses of the surface membrane and excretory system of Schistosoma mansoni to damage and to treatment with praziquantel and other biomolecules. Parasitology 132 (2006) 321-330
27. Hayeshi R., Masimirembwa C., Mukanganyama S., and Ungell A.L.B. The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. Eur J Pharmaceut Sci 29 (2006) 70-81
28. Ismail M., Botros S., Metwally A., et al. Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am J Trop Med Hyg 60 (1999) 932-935
29. Georges E., Bradley G., Gariepy J., and Ling V. Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies. Proc Natl Acad Sci USA 87 (1990) 152-156
30. Lewis F.A. Schistosomiasis. In: Coligan J.E., Kruisbeek A.M., and Margulies D.H. (Eds). Current protocols in immunology (1998), John Wiley & Sons, Inc., New York 19.1.1-19.1.28
31. Ismail M., Metwally A., Farghaly A., et al. Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. Am J Trop Med Hyg 55 (1996) 214-218
32. 50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates. Int J Parasitol 34L (2004) 979-987
33. Matz M.V. Amplification of representative cDNA samples from microscopic amounts of invertebrate tissue to search for new genes. Methods Mol Biol 183 (2002) 3-18
34. Franz O., Bruchhaus I., and Roeder T. Verification of differential gene transcription using virtual northern blotting. Nucleic Acids Res 27 (1999) e3
35. t method. Nat Protoc 3 (2008) 1101-1108
36. Mair G.R., Maule A.G., Day T.A., and Halton D.W. A confocal microscopical study of the musculature of adult Schistosoma mansoni. Parasitology 121 (2000) 163-170
37. Leopold G., Ungethüm W., Groll E., et al. Clinical pharmacology in normal volunteers of praziquantel, a new drug against schistosomes and cestodes. An example of a complex study covering both tolerance and pharmacokinetics. Eur J Clin Pharmacol 14 (1978) 281-291
38. William S., Sabra A., Ramzy F., et al. Stability and reproductive fitness of Schistosoma mansoni isolates with decreased sensitivity to praziquantel. Int J Parasitol 31 (2001) 1093-1100
39. Cioli D. Praziquantel: is there real resistance and are there alternatives?. Curr Opin Infect Dis 13 (2000) 659-663
40. Doenhoff M.J., Kusel J.R., Coles G.C., and Cioli D. Resistance of Schistosoma mansoni to praziquantel: is there a problem?. Trans Royal Soc Trop Med Hyg 96 (2002) 465-469