Change in the Molecular Dimension of a RAGE-Ligand Complex Triggers RAGE Signaling

Structure

Volumn 24, Issue 9, 2016, Pages 1509-1522

  Xue, Jing ^a   Manigrasso, Michaele ^b   Scalabrin, Matteo ^a   Rai, Vivek ^c   Reverdatto, Sergey ^a   Burz, David S ^a   Fabris, Daniele ^a   Schmidt, Ann Marie ^b   Shekhtman, Alexander ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c INSTITUTE OF LIFE SCIENCES   (India)

Author keywords

cancer; diabetes; diaphanous 1; hybrid method of structure determination; inflammation; mass spectrometry; NMR spectroscopy; pattern recognition; RAGE; receptor for advanced glycation end products; segmental labeling; signal transduction

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; LIGAND; BACTERIAL PROTEIN; CROSS LINKING REAGENT; CYAN FLUORESCENT PROTEIN; DIAPH1 PROTEIN, HUMAN; GREEN FLUORESCENT PROTEIN; MALEIMIDE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MOK PROTEIN, HUMAN; PHOTOPROTEIN; PROTEIN BINDING; RECOMBINANT PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SULFOSUCCINIMIDYL 4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE; TUMOR ANTIGEN; YELLOW FLUORESCENT PROTEIN, BACTERIA;

ARTICLE; CELL MEMBRANE; CELL SURFACE; COMPLEX FORMATION; CROSS LINKING; DIMERIZATION; MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; REPORTER GENE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; THERMODYNAMICS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NEOPLASM; BACTERIAL PROTEINS; BINDING SITES; CROSS-LINKING REAGENTS; GENE EXPRESSION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; LIGANDS; LUMINESCENT PROTEINS; MALEIMIDES; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR DOCKING SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; THERMODYNAMICS;

EID: 84981710200     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2016.06.021     Document Type: Article

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