Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism

Science

Volumn 353, Issue 6300, 2016, Pages 664-669

  Whicher, Jonathan R ^a   MacKinnon, Roderick ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; POTASSIUM; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL EAG1; KCNH1 PROTEIN, RAT; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; PROTEIN BINDING;

CHANNEL; ELECTRON MICROSCOPY; INHIBITOR; MAMMAL; POTASSIUM;

ARTICLE; CHEMICAL BINDING; CRYOELECTRON MICROSCOPY; ELECTRIC POTENTIAL; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHANNEL GATING; CHEMISTRY; PROTEIN TERTIARY STRUCTURE; RAT; ULTRASTRUCTURE;

MAMMALIA;

ANIMALS; BINDING SITES; CALMODULIN; CRYOELECTRON MICROSCOPY; ETHER-A-GO-GO POTASSIUM CHANNELS; ION CHANNEL GATING; POTASSIUM CHANNEL BLOCKERS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS;

EID: 84981510441     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf8070     Document Type: Article

References (42)

1. S. B. Long, E. B. Campbell, R. Mackinnon, Science 309, 897-903 (2005).
2. S. B. Long, X. Tao, E. B. Campbell, R. MacKinnon, Nature 450, 376-382 (2007).
3. J. Payandeh, T. Scheuer, N. Zheng, W. A. Catterall, Nature 475, 353-358 (2011).
4. J. Wu et al., Science 350, aad2395 (2015).
5. S. B. Long, E. B. Campbell, R. Mackinnon, Science 309, 903-908 (2005).
6. H. R. Guy, S. R. Durell, J. Warmke, R. Drysdale, B. Ganetzky, Science 254, 730 (1991).
7. M. Ju, D. Wray, Biochem. Biophys. Res. Commun. 342, 1088-1097 (2006).
8. H. Terlau, S. H. Heinemann, W. Stühmer, O. Pongs, J. Ludwig, J. Physiol. 502, 537-543 (1997).
9. J. H. Morais Cabral et al., Cell 95, 649-655 (1998).
10. F. W. Muskett et al., J. Biol. Chem. 286, 6184-6191 (2011).
11. J. Wang, M. C. Trudeau, A. M. Zappia, G. A. Robertson, J. Gen. Physiol. 112, 637-647 (1998).
12. W. N. Zagotta et al., Nature 425, 200-205 (2003).
13. T. I. Brelidze, A. E. Carlson, W. N. Zagotta, J. Biol. Chem. 284, 27989-27997 (2009).
14. T. I. Brelidze, A. E. Carlson, B. Sankaran, W. N. Zagotta, Nature 481, 530-533 (2012).
15. M. J. Marques-Carvalho et al., J. Mol. Biol. 423, 34-46 (2012).
16. Y. Haitin, A. E. Carlson, W. N. Zagotta, Nature 501, 444-448 (2013).
17. J. Ludwig et al., EMBO J. 13, 4451-4458 (1994).
18. R. Schönherr, K. Löber, S. H. Heinemann, EMBO J. 19, 3263-3271 (2000).
19. U. Ziechner et al., FEBS J. 273, 1074-1086 (2006).
20. L. S. Mortensen et al., J. Physiol. 593, 181-196 (2014).
21. P. Bijlenga et al., J. Physiol. 512, 317-323 (1998).
22. L. A. Pardo, A. Brüggemann, J. Camacho, W. Stühmer, J. Cell Biol. 143, 767-775 (1998).
23. L. A. Pardo et al., EMBO J. 18, 5540-5547 (1999).
24. B. Hemmerlein et al., Mol. Cancer 5, 41 (2006).
25. J. R. Agarwal, F. Griesinger, W. Stühmer, L. A. Pardo, Mol. Cancer 9, 18 (2010).
26. F. Mello de Queiroz, G. Suarez-Kurtz, W. Stühmer, L. A. Pardo, Mol. Cancer 5, 42 (2006).
27. B. R. Downie et al., J. Biol. Chem. 283, 36234-36240 (2008).
28. D. Gómez-Varela et al., Cancer Res. 67, 7343-7349 (2007).
29. J. García-Quiroz et al., PLOS ONE 7, e45063 (2012).
30. J. Ludwig, D. Owen, O. Pongs, EMBO J. 16, 6337-6345 (1997).
31. M. Ju, D. Wray, FEBS Lett 524, 204-210 (2002).
32. Y. Jiang et al., Nature 423, 33-41 (2003).
33. P. H. Hsu et al., PLOS ONE 7, e41203 (2012).
34. X. Tao, A. Lee, W. Limapichat, D. A. Dougherty, R. MacKinnon, Science 328, 67-73 (2010).
35. M. Zhang, J. Liu, G. N. Tseng, J. Gen. Physiol. 124, 703-718 (2004).
36. S. K. Aggarwal, R. MacKinnon, Neuron 16, 1169-1177 (1996).
37. S. A. Seoh, D. Sigg, D. M. Papazian, F. Bezanilla, Neuron 16, 1159-1167 (1996).
38. Z. Lu, A. M. Klem, Y. Ramu, Nature 413, 809-813 (2001).
39. D. del Camino, M. Holmgren, Y. Liu, G. Yellen, Nature 403, 321-325 (2000).
40. É. Lörinczi et al., Nat Commun 6, 6672 (2015).
41. R. M. Hardman, P. J. Stansfeld, S. Dalibalta, M. J. Sutcliffe, J. S. Mitcheson, J. Biol. Chem. 282, 31972-31981 (2007).
42. G. Barbato, M. Ikura, L. E. Kay, R. W. Pastor, A. Bax, Biochemistry 31, 5269-5278 (1992).