Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase

ACS Catalysis

Volumn 6, Issue 8, 2016, Pages 5405-5414

  Wu, Bian ^a,b,c   Wijma, Hein J ^a   Song, Lu ^b,c   Rozeboom, Henriëtte J ^a   Poloni, Claudia ^d   Tian, Yue ^b,c   Arif, Muhammad I ^a   Nuijens, Timo ^e   Quaedflieg, Peter J L M ^e   Szymanski, Wiktor ^d,f   Feringa, Ben L ^d   Janssen, Dick B ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

^e Brightlands Campus   (Netherlands)

^f UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

computational protein engineering; enzymatic catalysis; MD simulation; peptide modification; protein stability

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CATALYSIS; COMPUTATIONAL CHEMISTRY; CRYSTAL STRUCTURE; ENZYMES; GENETIC ENGINEERING; MOLECULAR DYNAMICS; POLYPEPTIDES; PROTEINS; REACTION KINETICS;

ENZYMATIC CATALYSIS; MD SIMULATION; MODIFICATION REACTIONS; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN CRYSTALLOGRAPHY; PROTEIN ENGINEERING; PROTEIN STABILITY; STENOTROPHOMONAS MALTOPHILIA;

PEPTIDES;

EID: 84981318353     PISSN: 21555435     EISSN: None     Source Type: Journal    
DOI: 10.1021/acscatal.6b01062     Document Type: Article

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