Discovery, synthesis, and functional characterization of a novel neuroprotective natural product from the fruit of alpinia oxyphylla for use in Parkinson's disease through LC/MS-based multivariate data analysis-guided fractionation

Journal of Proteome Research

Volumn 15, Issue 8, 2016, Pages 2595-2606

  Li, Guohui ^a,b   Zhang, Zaijun ^b,c   Quan, Quan ^a   Jiang, Renwang ^c   Szeto, Samuel S W ^a   Yuan, Shuai ^b   Wong, Wing Tak ^d   Lam, Herman H C ^a   Lee, Simon Ming Yuen ^b   Chu, Ivan K ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b University of Macau   (Macao)

^c JINAN UNIVERSITY   (China)

^d HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

natural products; neuroprotective; NRF2; Parkinson's disease; proteomics

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPINIA OXYPHYLLA EXTRACT; ANTIPARKINSON AGENT; NEUROPROTECTIVE AGENT; OXYPHYLLA A; PLANT EXTRACT; RASAGILINE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 5-METHYLHEXANOIC ACID; CRESOL; DOPAMINE RECEPTOR STIMULATING AGENT; HEXANOIC ACID DERIVATIVE;

ADULT; ALPINIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CELL LOSS; CEREBELLUM GRANULAR LAYER; CHEMOMETRIC ANALYSIS; CHEMOMETRICS; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG SYNTHESIS; EMBRYO; FRACTIONATION; FRUIT; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLOMICS; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEOMICS; RAT; SCALE UP; WESTERN BLOTTING; ZEBRA FISH; ANIMAL; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ISOLATION AND PURIFICATION; NERVE DEGENERATION;

ALPINIA; ANIMALS; CAPROATES; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, LIQUID; CRESOLS; DOPAMINE AGENTS; DOPAMINERGIC NEURONS; DRUG DISCOVERY; MASS SPECTROMETRY; MICE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; PLANT EXTRACTS; ZEBRAFISH;

EID: 84981297905     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.6b00152     Document Type: Article

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