The anti-cancer agent SU4312 unexpectedly protects against MPP+- induced neurotoxicity via selective and direct inhibition of neuronal NOS

British Journal of Pharmacology

Volumn 168, Issue 5, 2013, Pages 1201-1214

  Cui, Wei ^a   Zhang, Zaijun ^b,c   Li, Wenming ^a,g   Hu, Shengquan ^a   Mak, Shinghung ^a   Zhang, Huan ^a   Han, Renwen ^a   Yuan, Shuai ^b   Li, Sai ^c   Sa, Fei ^b   Xu, Daping ^b   Lin, Zhixiu ^d   Zuo, Zhong ^d   Rong, Jianhui ^e   Ma, Edmond Dik Lung ^f   Choi, Tony Chunglit ^a   Lee, Simon My ^b   Han, Yifan ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b University of Macau   (Macao)

^c JINAN UNIVERSITY   (China)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e THE UNIVERSITY OF HONG KONG   (Hong Kong)

^f HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

angiogenesis; MPP+; neuronal NOS; neuroprotection; Parkinson's disease; SU4312

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ANTINEOPLASTIC AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; SU 4312; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; VATALANIB;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TISSUE LEVEL; EMBRYO; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MONOTHERAPY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS; ZEBRA FISH;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; ANTINEOPLASTIC AGENTS; BEHAVIOR, ANIMAL; BRAIN; CELL DEATH; CELL LINE, TUMOR; EMBRYO, NONMAMMALIAN; ENZYME INHIBITORS; HUMANS; INDOLES; MOLECULAR DOCKING SIMULATION; MOTOR ACTIVITY; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; PC12 CELLS; RATS; RATS, SPRAGUE-DAWLEY; ZEBRAFISH;

EID: 84874225372     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12004     Document Type: Article

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