Tannoid principles of Emblica officinalis renovate cognitive deficits and attenuate amyloid pathologies against aluminum chloride induced rat model of Alzheimer’s disease

Nutritional Neuroscience

Volumn 19, Issue 6, 2016, Pages 269-278

  Justin Thenmozhi, Arokiasamy ^a   Dhivyabharathi, Mathiyazahan ^a   William Raja, Tharsius Raja ^a   Manivasagam, Thamilarasan ^a   Essa, Musthafa Mohamed ^b  

^a ANNAMALAI UNIVERSITY   (India)

^b SULTAN QABOOS UNIVERSITY   (Oman)

Author keywords

A beta peptide; AChE; AlCl3; Alzheimer s disease; Emblica officinalis; Memory; Tannoid principles

Indexed keywords

ACETYLCHOLINESTERASE; ALUMINUM CHLORIDE; AMYLOID; EMBLICA OFFICINALIS EXTRACT; SODIUM CHLORIDE; TANNIN; ALUMINUM DERIVATIVE; BIOLOGICAL MARKER; CHLORIDE; NERVE PROTEIN; NEUROPROTECTIVE AGENT; PLANT EXTRACT; TANNIN DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CONTROLLED STUDY; DISEASE COURSE; EMBLICA OFFICINALIS; ENZYME ASSAY; FAR WESTERN BLOTTING; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEARNING DISORDER; MALE; MEMORY DISORDER; MILD COGNITIVE IMPAIRMENT; MORRIS WATER MAZE TEST; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OPEN FIELD TEST; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPATIAL LEARNING; ANALYSIS; ANIMAL; AYURVEDA; BRAIN CORTEX; CHEMISTRY; COGNITIVE DYSFUNCTION; COMPARATIVE STUDY; DIETARY SUPPLEMENT; DISEASE MODEL; ETHNOPHARMACOLOGY; FRUIT; HIPPOCAMPUS; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PLAQUE, AMYLOID; RANDOMIZATION; WISTAR RAT;

ALUMINUM COMPOUNDS; ALZHEIMER DISEASE; ANIMALS; BIOMARKERS; CEREBRAL CORTEX; CHLORIDES; COGNITIVE DYSFUNCTION; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; ETHNOPHARMACOLOGY; FRUIT; HIPPOCAMPUS; MALE; MEDICINE, AYURVEDIC; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; PHYLLANTHUS EMBLICA; PLANT EXTRACTS; PLAQUE, AMYLOID; RANDOM ALLOCATION; RATS, WISTAR; TANNINS;

EID: 84981267563     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830515Y.0000000016     Document Type: Article

References (66)

1. Vasudevan M, Parle M. Pharmacological actions of Thespesia populnea relevant to Alzheimer’s disease. Phytomedicine 2006; 13: 677-87.
2. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer’s disease. Alzheimer’s Dement 2007;3: 186-91.
3. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 2002;297: 353-6.
4. Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci 2004;24: 7707-17.
5. Cain DP. Testing the NMDA, long-term potentiation and cholinergic hypotheses of spatial learning. Neurosci Behav Rev 1998;22: 181-93.
6. Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR. Alzheimer’s disease: evidence for the selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981;10: 122-6.
7. Armstrong RA. What causes Alzheimer’s disease? Folia Neuropathol 2013;51: 169-88.
8. Gauthier E, Fortier I, Courchesne F, Pepin P, Mortimer J, Gauvreau D. Aluminum forms in drinking water and risk of Alzheimer’s disease. Environ Res 2000;84: 234-46.
9. Walton JR. An aluminum-based rat model for Alzheimer’s disease exhibits oxidative damage, inhibition of PP2A activity, hyperphosphorylated tau and granulovacuolar degeneration. J Inorg Biochem 2007;101: 1275-84.
10. Savory J, Jagannatha Rao KS, Huang Y, Letada PR, Herman MM. Age-related hippocampal changes in Bcl-2: Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging. Neurotoxicology 1999;20: 805-18.
11. McLachlan DR, Bergeron C, Smith JE, Boomer D, Rifat SL. Risk for neuropathologically confirmed Alzheimer’s disease and residual aluminum in municipal drinking water employing weighted residential histories. Neurology 1996;46: 401-5.
12. Mangialasche FM, Solomon A, Winblad B, Mecocci P, Kivipelto M. Alzheimer’s disease: clinical trials and drug development. Lancet Neurol 2010;9: 702-16.
13. Essa MM, Vijayan RK, Castellano-Gonzalez G, Memon MA, Braidy N. Neuroprotective effect of natural products against Alzheimer’s disease. Neurochem Res 2012;37: 1829-42.
14. Thilakchand KR,Mathai RT, Simon P, Ravi RT, Baliga-RaoMP, Baliga M. Hepatoprotective properties of the Indian gooseberry (Emblica officinalisGaertn): a review.FoodFunct 2013;4: 1431-41.
15. Baliga MS, Dsouza JJ. Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur J Cancer Prev 2011;20: 225-39.
16. Baliga MS, Meera S, Mathai B, Rai MP, Pawar V, Palatty PL. Scientific validation of the ethnomedicinal properties of the ayurvedic drug Triphala: a review. Chin J Integr Med 2012;18: 946-54.
17. Vasudevan M, Parle M. Effect of Anwala churna (Emblica officinalis GAERTN.): an ayurvedic preparation on memory deficit rats. Yakugaku Zasshi 2007;127: 1701-7.
18. Sharma RK. Samhita Chikitsa Sthanam, 1st ed. Varanasi: India: BhagwanDashChoukhambha Sanskrit Series Office; 1988. p. 20-2.
19. Ghosal S, Tripathi VK, Chauhan S. Active constituents of Emblica officinalis. Part I, the chemistry and antioxidative effects of two hydrolysable tannins, emblicanin A and B. Indian J Chem 1996;35: 941-8.
20. Huang MT, Ho CT, Wang ZY, Ferraro T, Finnegan-Olive T, Lou YR, et al. Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 1992;13: 947-54.
21. Chung FL, Xu Y, Ho CT, Desai D, Han C. Protection against tobacco-specific, nitrosamine-induced lung tumorigenesis by green tea and its components. In: Huang MT, Ho CT, Lee CY, (eds.) Phenolic compounds in food and their effects on health. II. Antioxidants and cancer prevention. Washington, DC, USA: American Chemical Society; 1992. p. 300.
22. Kamei H, Koide T, Hashimoto Y, Kojima T, Hasegawa M. Tumor cell growth suppression by tannic acid. Cancer Biother Radiopharm 1999;14: 135-8.
23. Athar M, Khan WA, Mukhtar H. Effect of dietary tannic acid on epidermal, lung, and forestomach polycyclic aromatic hydrocarbon metabolism and tumorigenicity in Sencar mice. Cancer Res 1989;49: 5784-8.
24. Abdel-Aal RA, Assi AA, Kostandy BB. Rivastigmine reverses aluminum-induced behavioral changes in rats. Eur J Pharmacol 2011;659: 169-76.
25. Abdel-Aal RA, Assi AA, Kostandy BB. Memantine prevents aluminum-induced cognitive deficit in rats. Behav Brain Res 2011b;225: 31-8.
26. Walton JR and Wang MX. APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer’s disease. J Inorg Biochem 2009;103: 1548-54.
27. Flaten TP, Alfrey AC, Birchall JD, Savory J, Yokel RA. Status and future concerns of clinical and environmental aluminum toxicology. J Toxicol Environ Health 1996;48: 527-41.
28. Wills MR, Savory J. Aluminium poisoning: dialysis encephalopathy, osteomalacia and anaemia. Lancet 1983;322: 29-34.
29. Sanchez-Iglesiasa S, Soto-Oteroa R, Iglesias-Gonzaleza J, Barciela-Alonsob MC, Bermejo-Barrerab P, Mendez-Alvarez E. Analysis of brain regional distribution of aluminium in rats via oral and intraperitoneal administration. J Trace Elem Med Biol 2007;S1: 31-4.
30. Niu Q, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, et al. The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats. Neurotox Res 2007;12: 163-9.
31. Sun X, Liu Z, Zhang X, Zhang Z. Effects of aluminum on the number of neurons granulovacuolar degeneration in rats. Wei Sheng Yan Jiu 1999;28: 164-6.
32. Morris R. Developments of a water maze procedure for studying spatial learning in the rat. J Neurosci Meth 1984;11: 47-60.
33. Anandhan A, Tamilselvam K, Radhiga T, Rao S, Essa MM, Manivasagam T. Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson’s disease. Brain Res 2012;1433: 104-13.
34. Sethi P, Jyoti A, Singh R, Hussain E, Sharma D. Aluminiuminduced electrophysiological, biochemical and cognitive modifications in the hippocampus of aging rats. Neurotoxicology 2008; 29: 1069-79.
35. Hartmann M, Heumann R, Lessmann V. Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses. EMBO J 2001;20: 5887-97.
36. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193: 265-75.
37. Yumoto S, Nagai H, Matsuzaki H, Matsumura H, Tada W, Nagatsuma E, et al. Aluminium incorporation into the brain of rat fetuses and sucklings. Brain Res Bull 2001;55: 229-34.
38. Yumoto S, Nagai H, Kobayashi K, Tamate A, Kakimi S, Matsuzaki H. Al incorporation into the brain of suckling rats through maternal milk. J Inorg Biochem 2003;97: 155-60.
39. Roskams AJ, Connor JR. Aluminum access to the brain: a role for transferrin and its receptors. Proc Natl Acad Sci USA 1990; 87: 9024-7.
40. Jelenković A1, Jovanović MD, Stevanović I, Petronijević N, Bokonjić D, Zivković J, et al. Influence of the green tea leaf extract on neurotoxicity of aluminium chloride in rats. Phytother Res 2014;28: 82-7.
41. Bhattacharya A, Kumar M, Ghosal S, Bhattacharya SK. Effect of bioactive tannoid principles of Emblica officinalis on ironinduced hepatic toxicity in rats. Phytomedicine 2000a;7: 173-5.
42. Khandelwal S, Shukla LJ, Shanker R. Modulation of acute cadmium toxicity by Emblica officinalis fruit in rat. Indian J Exp Biol 2002;40: 564-70.
43. Sharma A, Sharma MK, Kumar M. Modulatory role of Emblica officinalis fruit extract against arsenic induced oxidative stress in Swiss albino mice. Chem Biol Interact 2009;180: 20-30.
44. Dhir H, Roy AK, Sharma A. Relative efficiency of Phyllanthus emblica fruit extract and ascorbic acid in modifying lead and aluminium- induced sister-chromatid exchanges in mouse bone marrow. Environ Mol Mutagen 1993;21: 229-36.
45. Dhir H, Roy AK, Sharma A, Talukder G. Modification of clastogenicity of lead and aluminium in mouse bone marrow cells by dietary ingestion of Phyllanthus emblica fruit extract. Mutat Res Genet Toxicol 1990;241: 305-12.
46. Zatta P, Zambenedetti P, Bruna V, Filippi B. Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species. Neuroreport 1994;5: 1777-80.
47. Kakkar V, Kaur IP. Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain. Food Chem Toxicol 2011;49: 2906-13.
48. Blennow K, de Leon MJ, Zetterberg H. Alzheimer’s disease. Lancet 2006;368: 387-403.
49. Wilkinson DG, Francis PT, Schwam E, Payne-Parrish J. Cholinesterase inhibitors used in the treatment of Alzheimer’s disease: the relationship between pharmacological effects and clinical efficacy. Drugs Aging 2004;21: 453-78.
50. Mathew M, Subramanian S. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders. PLoS One 2014;9: 86804.
51. Golechha M, Bhatia J, Arya DS. Studies on effects of Emblica officinalis (amla) on oxidative stress and cholinergic function in scopolamine induced amnesia in mice. J Environ Biol 2012;33: 95-100.
52. Baydar T, Papp A, Aydin A, Nagymajtenyi L, Schulz H, Isimer A, et al. Accumulation of aluminum in rat brain: does it lead to behavioral and electrophysiological changes? Biol Trace Elem Res 2003;92: 231-44.
53. KawaharaM, Kato-Negishi M. Link between aluminum and the pathogenesis of Alzheimer’s disease: the integration of the aluminum and amyloid cascade hypotheses. Int J Alzheimers Dis 2011;2011: 276393.
54. Ashwlayan VD, Singh R. Reversal effect of Phyllanthus emblica (Euphorbiaceae) rasayana on memory deficits in mice. Int J Appl Pharm 2011;2: 10-5.
55. Cam JA, Bu GJ. Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family. Mol Neurodegener 2006;1: 8.
56. Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, et al. Amyloid beta peptide load is correlated with increased betasecretase activity in sporadic Alzheimer’s disease patients. Proc Natl Acad Sci USA 2004;101: 3632-7.
57. Vassar R. Caspase-3 cleavage of GGA3 stabilizes BACE: implications for Alzheimer’s disease. Neuron 2007;54: 671-3.
58. Huse JT, Byant D, Yang Y, Pijak DS, D’Souza I, Lah JJ, et al. Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation. J Biol Chem 2003;278: 17141-9.
59. Mohajeri MH, Saini KD, Nitsch RM. Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology. J Neural Transm 2004;111: 413-25.
60. Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, Allsop D, et al. Distinct sites of intracellular production for Alzheimer’s disease A beta40/42 amyloid peptides. Nat Med 1997;3: 1016-20.
61. Justin Thenmozhi A, William Raja TR, Janakiraman U, Manivasagam T. Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer’s disease in Wistar rats. Neurochem Res 2015;40: 767-76.
62. Vamer JA, Jensen KF, Horvath W, Isaacson RL. Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Res 1998;784: 284-98.
63. Zhang ZJ, Qian YH, Hu HT, Yang H, Yang GD. The herbal medicine Dipsacus asper wall extract reduces the cognitive deficits and over expression of beta-amyloid protein induced by aluminum exposure. Life Sci 2003;73: 2443-54.
64. Govindarajan R, Vijayakumar M, Pushpangadan P. Antioxidant approach to disease management and the role of ‘rasayana’ herbs of ayurveda. J Ethnopharmacol 2005;99: 165-78.
65. Bhattacharya A, Ghosal S, Bhattacharya SK. Antioxidant activity of tannoid principles of Emblica officinalis (amla) in chronic stress induced changes in rat brain. Indian J Exp Biol 2000;38: 877-80.
66. Bhattachary SK, Bhattacharya D, Muruganandam AV. Effect of Emblica officinalis tannoids on a rat model of tardive dyskinesia. Indian J Exp Biol 2000;38: 945-7.