In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Mathew, Maya ^a   Subramanian, Sarada ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACORUS CALAMUS EXTRACT; ANTIOXIDANT; BACOPA MONNIERI EXTRACT; CEDRUS DEODERA EXTRACT; CELASTRUS PANICULATUS EXTRACT; CENTELLA ASIATICA EXTRACT; CHOLINESTERASE INHIBITOR; CONVOLVULUS PLURICAULIS EXTRACT; CORIANDRUM SATIVUM EXTRACT; EMBLICA OFFICINALIS EXTRACT; EVOLVULUS ALSINOIDES EXTRACT; GLYCYRRHIZA GLABRA EXTRACT; METHANOL; NARDOSTACHYS JATAMANSI EXTRACT; NELUMBO NUCIFERA EXTRACT; PLANT EXTRACT; POLYPHENOL; POMEGRANATE EXTRACT; RAULFIA SERPENTINA EXTRACT; SAUSSUREA LAPPA EXTRACT; TERMINALIA CHEBULA EXTRACT; TINOSPORA CORDIFOLIA EXTRACT; TRIGONELLA FOENUM EXTRACT; UNCLASSIFIED DRUG; VALERIANA WALLICHII EXTRACT; WITHANIA SOMNIFERA EXTRACT;

ACORUS CALAMUS; ANTIOXIDANT ACTIVITY; APOCYNACEAE; ARTICLE; AYURVEDA; BACOPA MONNIERI; CEDRUS; CEDRUS DEODERA; CELASTRUS; CELASTRUS PANICULATUS; CENTELLA ASIATICA; CHOLINESTERASE INHIBITION; COGNITIVE DEFECT; CONTROLLED STUDY; CONVOLVULACEAE; CONVOLVULUS; CONVOLVULUS PLURICAULIS; CORIANDER; DRUG DETERMINATION; DRUG SCREENING; EMBLICA OFFICINALIS; EVOLVULUS ALSINOIDES; GLYCYRRHIZA GLABRA; IC 50; IN VITRO STUDY; NELUMBO NUCIFERA; NONHUMAN; POMEGRANATE; RAULFIA SERPENTINA; SAUSSUREA; SAUSSUREA LAPPA; TERMINALIA CHEBULA; TINOSPORA CORDIFOLIA; TRIGONELLA; TRIGONELLA FOENUM; VALERIANA; VALERIANA JATAMANSI; VALERIANA WALLICHII; WITHANIA SOMNIFERA;

ACETYLCHOLINESTERASE; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CHOLINESTERASE INHIBITORS; COGNITION DISORDERS; DRUG EVALUATION, PRECLINICAL; HUMANS; METHANOL; PICRATES; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 84899867386     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086804     Document Type: Article

References (37)

1. Davies P, Maloney AJ (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2: 1403. (Pubitemid 8004505)
2. Mangialasche FM, Solomon A, Winblad B, Mecocci P, Kivipelto M (2010) Alzheimer's disease: clinical trials and drug development. Lancet Neurol. 9: 7022716.
3. Mukherjee PK, Kumar V, Mal M, Houghton PJ (2007) Acetylcholinesterase inhibitors from plants. Phytomedicine 14: 289-300. (Pubitemid 46415622)
4. Murray AP, Faraoni MB, Castro MJ, Alza NP, Cavallaro V (2013) Natural AChE inhibitors from plants and their contribution to Alzheimer's disease therapy. Curr Neuropharmacol 11: 388-413.
5. Nordberg A, Svensson AL (1998) Cholinesterase inhibitors in the treatment of Alzheimer's disease, a comparison of tolerability and pharmacology. Drug Safety 19: 465-480. (Pubitemid 29015406)
6. Mehta M, Adem A, Sabbagh M (2012) New acetylcholinesterase inhibitors for Alzheimer's disease. Int J Alzheimer's Disease Article ID 728983.
7. Mukherjee PK, Kumar V, Houghton PJ (2007) Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res 21: 1142-1145.
8. Oh MH, Houghton PJ, Whang WK, Cho JH (2004) Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine 11: 544-548. (Pubitemid 39312632)
9. Orhan I, Sener B, Choudhary MI, Khalid A (2004) Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. J. Ethnopharmacol 91: 57-60. (Pubitemid 38270227)
10. Ferreira A, Proenc C, Serralheiro MLM, Araujo MEM (2006) The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. J Ethnopharmacol 108: 31-37. (Pubitemid 44498982)
11. Ingkaninan K, Temkitthawon P, Chuenchom K, Yuyaem T, Thongnoi W (2003) Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies. J Ethnopharmacol 89: 261-264. (Pubitemid 37378200)
12. Viña J, Lloret A, Giraldo E, Badia MC, Alonso MD (2011) Antioxidant pathways in Alzheimer's disease: possibilities of intervention. Curr Pharm Des 17(35): 3861-3864.
13. Gutzmann H, Hadler D (1998) Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study. J Neural Transm Suppl 54: 301-310. (Pubitemid 28539367)
14. Bolognesi ML, Matera R, Minarini A, Rosini M, Melchiorre C (2009) Alzheimer's disease: new approaches to drug discovery. Curr Opin Chem Biol 13: 303-308.
15. Capurro V, Busquet P, Lopes JP, Bertorelli R, Tarozzo G et al. (2013) Pharmacological characterization of Memoquin, a multi-target compound for the treatment of Alzheimer's disease, PLoS One 8(2): e56870.
16. Warrier PK, Nambiar VPK, Ramankutty C (1993-96) Indian Medicinal Plants: A Compendium of 500 Species (vol. I-V) Universities Press, (India) Private Ltd., New Delhi.
17. Manyam BV (1999) Dementia in ayurveda. J Altern Complement Med 5: 81-88.
18. Rao RV, Descamps O, John V, Bredesen DE (2012) Ayurvedic medicinal plants for Alzheimer's disease: a review. Alzheimers Res Ther 4: 22.
19. Atoui A, Mansouri A, Boskou G, Kefalas P (2005) Tea and herbal infusions: their antioxidant activity and phenolic profile. Food Chem 89: 27-36. (Pubitemid 39024479)
20. Tepe B, Daferera D, Sokmen A, Sokmen M, Polissiou M (2005) Antimicrobial and antioxidant activities of the essential oil and various extracts of Salvia tomentosa Miller (Lamiaceae). Food Chem 90: 333-340. (Pubitemid 39361067)
21. Ellman GL, Courtney KD, Andres V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol 7: 88-95.
22. Rice-Evans C, Miller N, Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20: 933-956. (Pubitemid 26157509)
23. Naik GH, Priyadarsini KI, Bhagirathi RG, Mishra B, Mishra KP et al. (2005) In vitro antioxidant studies and free radical reactions of triphala, an ayurvedic formulation and its constituents. Phytother Res 19: 582-586. (Pubitemid 41375239)
24. Mathew M, Sagar BKC, Subramanian S (2013) Identification of small molecule inhibitors against amyloid b (Ab) oligomerization and toxicity from nootropic Ayurvedic herbal extracts Int J Pharm Sci Res 4: 4685-4691.
25. Mathew M, Subramanian S (2012) Evaluation of the anti-amyloidogenic potential of nootropic herbal extracts in vitro. Int J Pharm Sci Res 3: 1000-1004.
26. Vasudevan M, Parle M (2007) Memory enhancing activity of Anwala churna (Emblica officinalis Gaertn.): An Ayurvedic preparation. Physiol Behav 91: 46-54. (Pubitemid 46628968)
27. Peckels CM, Alexander NS, Wilson GN, Karty JM, Matera KM (2013) Trisubstituted phenolic compounds as inhibitors of acetylcholinesterase and amyloid beta aggregate formation. Curr Enz Inhibition 9: 67-74.
28. Joshi H, Parle M (2006) Nardostachys jatamansi improves learning and memory in mice. J Med Food 9: 113-118. (Pubitemid 44153626)
29. Karkada G, Shenoy KB, Halahalli H, Karanth KS (2012) Nardostachys jatamansi extract prevents chronic restraint stress-induced learning and memory deficits in a radial arm maze task. J Nat Sci Biol Med 3: 125-132.
30. Ling ZQ, Xie BJ, Yang EL (2005) Isolation, characterization, and determination of antioxidative activity of oligomeric procyanidins from the seedpod of Nelumbo nucifera Gaertn. J Agric Food Chem 53: 2441-2445.
31. Yang ZD, Zhang X, Du J, Ma ZJ, Guo F et al. (2011) An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure-activity correlations. Nat Prod Res 26: 387-392.
32. Jung HA, Jung HA, Jin SE, Choi RJ, Kim DH et al. (2010) Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1. Life Sci 87: 420-430.
33. Gil MI, Tomás-Barberán FA, Hess-Pierce B, Holcroft DM, Kader AA (2000) Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 48: 4581-4589.
34. Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M et al. (2006) Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease. Neurobiol Dis 24: 506-515. (Pubitemid 44716679)
35. Kwak HM, Jeon SY, Sohng BH, Kim JG, Lee JM et al. (2005) β-Secretase (BACE1) inhibitors from pomegranate (Punica granatum) husk. Arch Pharm Res 28: 1328-1332.
36. Itoh A, Kumashiro T, Yamaguchi M, Nagakura N, Mizushina Yet al. (2005) Indole alkaloids and other constituents of Rauwolfia serpentina. J Nat Prod 68: 848-852. (Pubitemid 41017496)
37. Arya U, Dwivedi H, Subramanyam JR (2009) Reserpine ameliorates Aβ toxicity in the Alzheimer's disease model in Caenorhabditis elegans. Exp Gerontol 44: 462-466.