Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production

Biochemistry

Volumn 55, Issue 31, 2016, Pages 4356-4365

  Peng, Hwei Ming ^a   Im, Sang Choul ^a   Pearl, Naw May ^a   Turcu, Adina F ^a   Rege, Juilee ^a   Waskell, Lucy ^a   Auchus, Richard J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; DISEASES;

ANDROGEN PRODUCTION; COUPLING EFFICIENCY; HUMAN CYTOCHROME; NATURALLY OCCURRING; PRODUCT FORMATION; PROSTATE CANCERS; SIDE PRODUCTS; TIGHTLY-COUPLED;

SUBSTRATES;

17 HYDROXYPREGNENOLONE; CYTOCHROME B5; CYTOCHROME P450; CYTOCHROME P450 17A1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID 17ALPHA MONOOXYGENASE; UNCLASSIFIED DRUG; ABIRATERONE; ANDROGEN; ANDROSTANE DERIVATIVE; CYP17A1 PROTEIN, HUMAN; ENZYME INHIBITOR; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ANDROGEN SYNTHESIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HYDROXYLATION; OXIDATION; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; BIOSYNTHESIS; CHEMISTRY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; GENETICS; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANDROGENS; ANDROSTENES; CATALYTIC DOMAIN; CYTOCHROMES B5; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STEROID 17-ALPHA-HYDROXYLASE;

EID: 84981250372     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.6b00532     Document Type: Article

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