Active site proton delivery and the lyase activity of human CYP17A1

Biochemical and Biophysical Research Communications

Volumn 443, Issue 1, 2014, Pages 179-184

  Khatri, Yogan ^a   Gregory, Michael C ^a   Grinkova, Yelena V ^a   Denisov, Ilia G ^a   Sligar, Stephen G ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Compound I; CYP17A1; Nucelophilic attack; Proton delivery; T306A

Indexed keywords

CARBON; CYTOCHROME P450 17; CYTOCHROME P450 17A1; CYTOCHROME P450 REDUCTASE; NANODISC; OXYGENASE; PREGNENOLONE; PROGESTERONE; PYRIDINE NUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; HYDROXYLATION; MUTATION; NONHUMAN; OXIDATION; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEROID METABOLISM; TURNOVER TIME;

17Α-HYDROXY-PREGNENOLONE; 17Α-HYDROXY-PROGESTERONE; AD; ANDROSTENEDIONE; COMPOUND I; CPD I; CYP17A1; CYT-B(5); CYTOCHROME B(5); DEHYDROEPIANDROSTERONE; DHEA; NUCELOPHILIC ATTACK; OH-PREG; OH-PROG; PREG; PREGNENOLONE; PROG; PROGESTERONE; PROTON DELIVERY; T306A;

CATALYSIS; CATALYTIC DOMAIN; HUMANS; MUTATION; PREGNENOLONE; PROGESTERONE; PROTONS; STEROID 17-ALPHA-HYDROXYLASE; THREONINE;

EID: 84890855998     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.11.094     Document Type: Article

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