Mitochondrion-Mediated Apoptosis Induced by Acrylamide is Regulated by a Balance Between Nrf2 Antioxidant and MAPK Signaling Pathways in PC12 Cells

Molecular Neurobiology

Volumn 54, Issue 6, 2017, Pages 4781-4794

  Pan, Xiaoqi ^a,b   Yan, Dandan ^a   Wang, Dun ^a   Wu, Xu ^a   Zhao, Wanyun ^a   Lu, Qing ^a   Yan, Hong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Acrylamide; Apoptosis; MAPK; Nrf2; Oxidative stress

Indexed keywords

ACRYLAMIDE; CASPASE 3; CASPASE 9; CYTOCHROME C; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; MALONALDEHYDE; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MEMBRANE DEPOLARIZATION; CELL VIABILITY ASSAY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME RELEASE; HETEROCHROMATIN; HUMAN; IMMUNOCYTOCHEMISTRY; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOPHAGY; MOLECULAR INTERACTION; NEUROTOXICITY; OXIDATIVE STRESS; PHEOCHROMOCYTOMA CELL LINE; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL NUCLEUS; DRUG EFFECTS; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; MAPK SIGNALING; METABOLISM; MITOCHONDRION; PC12 CELL LINE; PROTEIN TRANSPORT; RAT; ULTRASTRUCTURE;

ACRYLAMIDE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL NUCLEUS; GENE SILENCING; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALONDIALDEHYDE; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PROTEIN TRANSPORT; RATS; TRANSCRIPTION, GENETIC;

EID: 84981170314     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-016-0021-1     Document Type: Article

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