Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles

Nature Nanotechnology

Volumn 11, Issue 10, 2016, Pages 890-899

  Kishimoto, Takashi K ^a   Ferrari, Joseph D ^a   Lamothe, Robert A ^a   Kolte, Pallavi N ^a   Griset, Aaron P ^a   O'Neil, Conlin ^a   Chan, Victor ^a   Browning, Erica ^a,b   Chalishazar, Aditi ^a,c   Kuhlman, William ^a   Fu, Fen Ni ^a   Viseux, Nelly ^a   Altreuter, David H ^a,d   Johnston, Lloyd ^a   Maldonado, Roberto ^a  

^a Selecta Biosciences   (United States)

^b Structural Proteomics   (United States)

^c Quiet Therapeutics Inc ^*  (United States)

^d Quiet Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; MAMMALS; NANOPARTICLES;

BIOLOGIC DRUGS; DENDRITIC CELLS; HYPERSENSITIVITY REACTION; NON-HUMAN PRIMATE; POLY(LACTIC-CO-GLYCOLIC ACID); REGULATORY T CELLS; TRANSGENIC MICE; URIC ACIDS;

DRUG DELIVERY;

ADALIMUMAB; B7 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; DIPYRONE; GAMMA INTERFERON; KEYHOLE LIMPET HEMOCYANIN; METHOTREXATE; NANOCARRIER; OVALBUMIN; PEGLOTICASE; POLYGLACTIN; RAPAMYCIN; RECOMBINANT URATE OXIDASE; TUMOR NECROSIS FACTOR; URATE OXIDASE; URIC ACID; LACTIC ACID; NANOPARTICLE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; RECOMBINANT VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE ACTIVATION; BIOLOGICAL THERAPY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; EXPERIMENTAL ARTHRITIS; EXPERIMENTAL DELAYED TYPE HYPERSENSITIVITY; FEMALE; GERMINAL CENTER; HYPERURICEMIA; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INJECTION SITE REACTION; LOW DRUG DOSE; LYMPHOCYTE DIFFERENTIATION; MACACA FASCICULARIS; MONOTHERAPY; MOUSE; NANOENCAPSULATION; NANOPHARMACEUTICS; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; SYSTEMIC ANAPHYLAXIS; T LYMPHOCYTE ACTIVATION; URIC ACID BLOOD LEVEL; ANAPHYLAXIS; ANIMAL; CHEMISTRY; DRUG EFFECT; GENETICS; IMMUNOLOGY; OSTEOLYSIS; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE;

ADALIMUMAB; ANAPHYLAXIS; ANIMALS; ARTHRITIS, EXPERIMENTAL; BONE RESORPTION; DRUG DELIVERY SYSTEMS; FEMALE; HYPERURICEMIA; IMMUNE TOLERANCE; LACTIC ACID; MACACA FASCICULARIS; MICE, TRANSGENIC; NANOPARTICLES; POLYGLYCOLIC ACID; RATS, SPRAGUE-DAWLEY; SIROLIMUS; T-LYMPHOCYTES, REGULATORY; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, SYNTHETIC;

EID: 84980351348     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2016.135     Document Type: Article

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