ADD ON THERAPY;
ANTIBODY RESPONSE;
ANTIGEN ANTIBODY COMPLEX;
AUTOIMMUNE DISEASE;
BIOLOGICAL THERAPY;
CHRONIC LYMPHATIC LEUKEMIA;
CLINICAL TRIAL;
CROHN DISEASE;
DRUG BINDING;
DRUG BLOOD LEVEL;
DRUG CLEARANCE;
DRUG DOSE ESCALATION;
DRUG EFFICACY;
DRUG EXPOSURE;
DRUG MECHANISM;
DRUG MEGADOSE;
DRUG RESPONSE;
HUMAN;
IMMUNE RESPONSE;
IMMUNOGENICITY;
IMMUNOLOGICAL TOLERANCE;
MULTIPLE SCLEROSIS;
NONHUMAN;
PRIORITY JOURNAL;
RHEUMATOID ARTHRITIS;
SHORT SURVEY;
T CELL LYMPHOMA;
ANIMALS;
ANTIBODIES, MONOCLONAL;
ANTIBODIES, NEOPLASM;
ANTINEOPLASTIC AGENTS;
CLINICAL TRIALS, PHASE II AS TOPIC;
DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC;
DRUG ADMINISTRATION SCHEDULE;
HUMANS;
IMMUNE TOLERANCE;
IMMUNOTHERAPY;
MICE;
PROTEIN BINDING;
Dealing with immunogenicity of biologicals: Assessment and clinical relevance
Wolbink, G. J., Aarden, L. A. & Dijkmans, B. A. Dealing with immunogenicity of biologicals: assessment and clinical relevance. Curr. Opin. Rheumatol. 21, 211-215 (2009).
Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
DOI 10.1056/NEJMoa020888
Baert, F. et al. influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N. Engl. J. Med. 348, 601-608 (2003). (Pubitemid 36204954)
Clinical response to adalimumab: Relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis
Bartelds, G. M. et al. Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis. Ann. Rheum. Dis. 66, 921-926 (2007).
CAMPATH-1H, a humanized monoclonal antibody, in refractory rheumatoid arthritis. An intravenous dose-escalation study
Weinblatt, M. E. et al. CAMPATH-1H, a humanized monoclonal antibody, in refractory rheumatoid arthritis. An intravenous dose-escalation study. Arthritis Rheum. 38, 1589-1594 (1995).
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
Maini, R. N. et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum. 41, 1552-1563 (1998).
Optimization algorithms for functional deimmunization of therapeutic proteins
Parker, A. S., Zheng, W., Griswold, K. E. & Bailey-Kellogg, C. Optimization algorithms for functional deimmunization of therapeutic proteins. BMC Bioinformatics 11, 180 (2010).