LncRNA-MIF, a c-Myc-activated long non-coding RNA, suppresses glycolysis by promoting Fbxw7-mediated c-Myc degradation

EMBO Reports

Volumn 17, Issue 8, 2016, Pages 1204-1220

  Zhang, Pengfei ^a   Cao, Limian ^a   Fan, Pingsheng ^b   Mei, Yide ^a   Wu, Mian ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

c Myc; Fbxw7; glycolysis; lncRNA; microRNA

Indexed keywords

C MYC INHIBITORY FACTOR; COMPLEMENTARY DNA; FBXW 7 PROTEIN; LONG UNTRANSLATED RNA; MICRORNA; MICRORNA 34A; MICRORNA 586; MYC PROTEIN; PROTEIN; PROTEIN C JUN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; F BOX PROTEIN; FBXW7 PROTEIN, HUMAN; MIRN-586 MICRORNA, HUMAN; PROTEIN BINDING; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STABILITY; ANIMAL; CELL CYCLE; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; ONCOGENE; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CELL PROLIFERATION; F-BOX PROTEINS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENES, JUN; GENES, TUMOR SUPPRESSOR; GLYCOLYSIS; MALE; MICE; MICRORNAS; PROTEIN BINDING; PROTEIN STABILITY; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MYC; RNA, LONG NONCODING; TRANSCRIPTIONAL ACTIVATION; UBIQUITIN-PROTEIN LIGASES;

EID: 84980021804     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201642067     Document Type: Article

References (52)

1. Bishop JM (1982) Retroviruses and cancer genes. Adv Cancer Res 37: 1–32
2. Bister K, Jansen HW (1986) Oncogenes in retroviruses and cells: biochemistry and molecular genetics. Adv Cancer Res 47: 99–188
3. Vita M, Henriksson M (2006) The Myc oncoprotein as a therapeutic target for human cancer. Semin Cancer Biol 16: 318–330
4. Cole MD (1986) The myc oncogene: its role in transformation and differentiation. Annu Rev Genet 20: 361–384
5. Popescu NC, Zimonjic DB (2002) Chromosome-mediated alterations of the MYC gene in human cancer. J Cell Mol Med 6: 151–159
6. Meyer N, Penn LZ (2008) MYC – TIMELINE reflecting on 25 years with MYC. Nat Rev Cancer 8: 976–990
7. Bhatia K, Huppi K, Spangler G, Siwarski D, Iyer R, Magrath I (1993) Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Nat Genet 5: 56–61
8. Clark HM, Yano T, Otsuki T, Jaffe ES, Shibata D, Raffeld M (1994) Mutations in the coding region of C-Myc in aids-associated and other aggressive lymphomas. Cancer Res 54: 3383–3386
9. Dang CV (2012) MYC on the path to cancer. Cell 149: 22–35
10. Lin CY, Loven J, Rahl PB, Paranal RM, Burge CB, Bradner JE, Lee TI, Young RA (2012) Transcriptional amplification in tumor cells with elevated c-Myc. Cell 151: 56–67
11. Nie ZQ, Hu GQ, Wei G, Cui KR, Yamane A, Resch W, Wang RN, Green DR, Tessarollo L, Casellas R et al (2012) c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 151: 68–79
12. Fernandez PC, Frank SR, Wang LQ, Schroeder M, Liu SX, Greene J, Cocito A, Amati B (2003) Genomic targets of the human c-Myc protein. Gene Dev 17: 1115–1129
13. Dang CV (2013) MYC, metabolism, cell growth, and tumorigenesis. Csh Perspect Med 3: a014217
14. Dang CV, O'Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F (2006) The c-Myc target gene network. Semin Cancer Biol 16: 253–264
15. Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG et al (2012) The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res 22: 1775–1789
16. Iorio MV, Croce CM (2012) MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 4: 143–159
17. Bonasio R, Shiekhattar R (2014) Regulation of transcription by long noncoding RNAs. Annu Rev Genet 48: 433–455
18. Wilusz JE, Freier SM, Spector DL (2008) 3′ end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell 135: 919–932
19. Kartha RV, Subramanian S (2014) Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation. Front Genet 5: 8
20. Tay Y, Rinn J, Pandolfi PP (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature 505: 344–352
21. Gutschner T, Diederichs S (2012) The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol 9: 703–719
22. Qiu MT, Hu JW, Yin R, Xu L (2013) Long noncoding RNA: an emerging paradigm of cancer research. Tumour Biol 34: 613–620
23. Liu J, Levens D (2006) Making myc. Curr Top Microbiol Immunol 302: 1–32
24. Wierstra I, Alves J (2008) The c-myc promoter: still MysterY and challenge. Adv Cancer Res 99: 113–333
25. Hann SR (2006) Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function. Semin Cancer Biol 16: 288–302
26. Wall M, Poortinga G, Hannan KM, Pearson RB, Hannan RD, McArthur GA (2008) Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation. Blood 112: 2305–2317
27. Farrell AS, Sears RC (2014) MYC degradation. Cold Spring Harb Perspect Med 4: a014365
28. Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE (2004) The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci USA 101: 9085–9090
29. Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H, Ishida N, Okumura F, Nakayama K, Nakayama KI (2004) Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 23: 2116–2125
30. Hofmann JW, Zhao XA, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang YQ, Feng B et al (2015) Reduced expression of MYC increases longevity and enhances healthspan. Cell 160: 477–488
31. Wu S, Yin X, Fang X, Zheng J, Li L, Liu X, Chu L (2015) c-MYC responds to glucose deprivation in a cell-type-dependent manner. Cell Death Discov 1: 15057
32. Hill CG, Jabbari N, Matyunina LV, McDonald JF (2014) Functional and evolutionary significance of human microRNA seed region mutations. PLoS ONE 9: e115241
33. Welcker M, Clurman BE (2008) FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 8: 83–93
34. Hsieh AL, Walton ZE, Altman BJ, Stine ZE, Dang CV (2015) MYC and metabolism on the path to cancer. Semin Cell Dev Biol 43: 11–21
35. Hart JR, Roberts TC, Weinberg MS, Morris KV, Vogt PK (2014) MYC regulates the non-coding transcriptome. Oncotarget 5: 12543–12554
36. Song L, Dai T, Xie Y, Wang C, Lin C, Wu Z, Ying Z, Wu J, Li M, Li J (2012) Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair. J Mol Cell Biol 4: 108–117
37. Winkle M, van den Berg A, Tayari M, Sietzema J, Terpstra M, Kortman G, de Jong D, Visser L, Diepstra A, Kok K et al (2015) Long noncoding RNAs as a novel component of the Myc transcriptional network. FASEB J 29: 2338–2346
38. Zheng GX, Do BT, Webster DE, Khavari PA, Chang HY (2014) Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs. Nat Struct Mol Biol 21: 585–590
39. Barsyte-Lovejoy D, Lau SK, Boutros PC, Khosravi F, Jurisica I, Andrulis IL, Tsao MS, Penn LZ (2006) The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Res 66: 5330–5337
40. Grossi E, Sanchez Y, Huarte M (2015) Expanding the p53 regulatory network: LncRNAs take up the challenge. Biochim Biophys Acta 1859: 200–208
41. He X, Tan X, Wang X, Jin H, Liu L, Ma L, Yu H, Fan Z (2014) C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion. Tumour Biol 35: 12181–12188
42. Kim T, Cui R, Jeon YJ, Fadda P, Alder H, Croce CM (2015) MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression. Oncotarget 6: 18780–18789
43. Kim T, Jeon YJ, Cui R, Lee JH, Peng Y, Kim SH, Tili E, Alder H, Croce CM (2015) Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. J Natl Cancer Inst 107: dju505
44. Xiang JF, Yin QF, Chen T, Zhang Y, Zhang XO, Wu Z, Zhang S, Wang HB, Ge J, Lu X et al (2014) Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. Cell Res 24: 513–531
45. Yang F, Xue X, Zheng L, Bi J, Zhou Y, Zhi K, Gu Y, Fang G (2014) Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. FEBS J 281: 802–813
46. Hu G, Lou Z, Gupta M (2014) The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation. PLoS ONE 9: e107016
47. Prensner JR, Chen W, Han S, Iyer MK, Cao Q, Kothari V, Evans JR, Knudsen KE, Paulsen MT, Ljungman M et al (2014) The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc. Neoplasia 16: 900–908
48. Tseng YY, Moriarity BS, Gong W, Akiyama R, Tiwari A, Kawakami H, Ronning P, Reuland B, Guenther K, Beadnell TC et al (2014) PVT1 dependence in cancer with MYC copy-number increase. Nature 512: 82–86
49. Weinstein IB (2002) Cancer: addiction to oncogenes – the Achilles heal of cancer. Science 297: 63–64
50. Chen BJ, Wu YL, Tanaka Y, Zhang W (2014) Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci 10: 1084–1096
51. Mitra SA, Mitra AP, Triche TJ (2012) A central role for long non-coding RNA in cancer. Front Genet 3: 17
52. Yang F, Zhang H, Mei Y, Wu M (2014) Reciprocal regulation of HIF-1alpha and lincRNA-p21 modulates the Warburg effect. Mol Cell 53: 88–100