The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc

Neoplasia (United States)

Volumn 16, Issue 11, 2014, Pages 900-908

  Prensner, John R ^a   Chen, Wei ^a   Han, Sumin ^a   Iyer, Matthew K ^a   Cao, Qi ^a,c   Kothari, Vishal ^a   Evans, Joseph R ^a   Knudsen, Karen E ^b   Paulsen, Michelle T ^a   Ljungman, Mats ^a   Lawrence, Theodore S ^a   Chinnaiyan, Arul M ^a   Feng, Felix Y ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

3'UTR; Cell proliferation; CMyc; LncRNA; PCAT 1

Indexed keywords

LONG UNTRANSLATED RNA; LONG UNTRANSLATED RNA PCAT 1; MICRORNA; MYC PROTEIN; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MYC PROTEIN, HUMAN; PCAT-1 LNCRNA, HUMAN;

3' UNTRANSLATED REGION; ARTICLE; CELL PROLIFERATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MALE; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; PROTEIN TARGETING; TRANSCRIPTION REGULATION; UPREGULATION; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PROSTATE TUMOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, LONG NONCODING;

EID: 84921374786     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1016/j.neo.2014.09.001     Document Type: Article

References (48)

1. Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, et al. Landscape of transcription in human cells. Nature 2012, 489:101-108.
2. Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res 2012, 22:1775-1789.
3. Huarte M, Rinn JL Large non-coding RNAs: missing links in cancer?. Hum Mol Genet 2010, 19:R152-R161.
4. Gibb EA, Brown CJ, Lam WL The functional role of long non-coding RNA in human carcinomas. Mol Cancer 2011, 10:38.
5. Prensner JR, Chinnaiyan AM The emergence of lncRNAs in cancer biology. Cancer Discov 2011, 1:391-407.
6. de Kok JB, Verhaegh GW, Roelofs RW, Hessels D, Kiemeney LA, Aalders TW, Swinkels DW, Schalken JA DD3(PCA3), a very sensitive and specific marker to detect prostate tumors. Cancer Res 2002, 62:2695-2698.
7. Tomlins SA, Aubin SM, Siddiqui J, Lonigro RJ, Sefton-Miller L, Miick S, Williamsen S, Hodge P, Meinke J, Blase A, et al. Urine TMPRSS2:ERG fusion transcript stratifies prostate cancer risk in men with elevated serum PSA. Sci Transl Med 2011, 3:94ra72.
8. Srikantan V, Zou Z, Petrovics G, Xu L, Augustus M, Davis L, Livezey JR, Connell T, Sesterhenn IA, Yoshino K, et al. PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Proc Natl Acad Sci U S A 2000, 97:12216-12221.
9. Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, Chen Y, Liu XS Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol 2013, 20:908-913.
10. Prensner JR, Iyer MK, Balbin OA, Dhanasekaran SM, Cao Q, Brenner JC, Laxman B, Asangani IA, Grasso CS, Kominsky HD, et al. Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat Biotechnol 2011, 29:742-749.
11. Prensner JR, Iyer MK, Sahu A, Asangani IA, Cao Q, Patel L, Vergara IA, Davicioni E, Erho N, Ghadessi M, et al. The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet 2013, 45:1392-1398.
12. Ge X, Chen Y, Liao X, Liu D, Li F, Ruan H, Jia W Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer. Med Oncol 2013, 30:588.
13. Prensner JR, Chen W, Iyer MK, Cao Q, Ma T, Han S, Sahu A, Malik R, Wilder-Romans K, Navone N, et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res 2014, 74:1651-1660.
14. Cao Q, Mani RS, Ateeq B, Dhanasekaran SM, Asangani IA, Prensner JR, Kim JH, Brenner JC, Jing X, Cao X, et al. Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer. Cancer Cell 2011, 20:187-199.
15. Han S, Brenner JC, Sabolch A, Jackson W, Speers C, Wilder-Romans K, Knudsen KE, Lawrence TS, Chinnaiyan AM, Feng FY Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition. Neoplasia 2013, 15:1207-1217.
16. Ørom UA, Derrien T, Beringer M, Gumireddy K, Gardini A, Bussotti G, Lai F, Zytnicki M, Notredame C, Huang Q, et al. Long noncoding RNAs with enhancer-like function in human cells. Cell 2010, 143:46-58.
17. Tinel M, Elkahwaji J, Robin MA, Fardel N, Descatoire V, Haouzi D, Berson A, Pessayre D Interleukin-2 overexpresses c-myc and down-regulates cytochrome P-450 in rat hepatocytes. J Pharmacol Exp Ther 1999, 289:649-655.
18. Tinel M, Berson A, Elkahwaji J, Cresteil T, Beaune P, Pessayre D Downregulation of cytochromes P450 in growth-stimulated rat hepatocytes: role of c-Myc induction and impaired C/EBP binding to DNA. J Hepatol 2003, 39:171-178.
19. Arora V, Knapp DC, Smith BL, Statdfield ML, Stein DA, Reddy MT, Weller DD, Iversen PL c-Myc antisense limits rat liver regeneration and indicates role for c-Myc in regulating cytochrome P-450 3A activity. J Pharmacol Exp Ther 2000, 292:921-928.
20. Ruggero D The role of Myc-induced protein synthesis in cancer. Cancer Res 2009, 69:8839-8843.
21. Schmidt EV The role of c-myc in regulation of translation initiation. Oncogene 2004, 23:3217-3221.
22. Seoane J, Pouponnot C, Staller P, Schader M, Eilers M, Massague J TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol 2001, 3:400-408.
23. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, et al. Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol 2001, 3:392-399.
24. Djuranovic S, Nahvi A, Green R A parsimonious model for gene regulation by miRNAs. Science 2011, 331:550-553.
25. Bartel DP MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
26. Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 2010, 465:1033-1038.
27. Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?. Cell 2011, 146:353-358.
28. Prensner JR, Chen W, Iyer MK, Cao Q, Ma T, Han S, Sahu A, Malik R, Wilder-Romans K, Navone N, et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res 2014, 74:1651-1660.
29. Yamamura S, Saini S, Majid S, Hirata H, Ueno K, Deng G, Dahiya R MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells. PLoS One 2012, 7:e29722.
30. Siemens H, Jackstadt R, Hunten S, Kaller M, Menssen A, Gotz U, Hermeking H miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 2011, 10:4256-4271.
31. Benassi B, Flavin R, Marchionni L, Zanata S, Pan Y, Chowdhury D, Marani M, Strano S, Muti P, Blandino G, et al. MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer. Cancer Discov 2012, 2:236-247.
32. Kim JH, Dhanasekaran SM, Mehra R, Tomlins SA, Gu W, Yu J, Kumar-Sinha C, Cao X, Dash A, Wang L, et al. Integrative analysis of genomic aberrations associated with prostate cancer progression. Cancer Res 2007, 67:8229-8239.
33. Meyer N, Penn LZ Reflecting on 25 years with MYC. Nat Rev Cancer 2008, 8:976-990.
34. Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, Burge CB, Sharp PA, Young RA c-Myc regulates transcriptional pause release. Cell 2010, 141:432-445.
35. Yamamura S, Saini S, Majid S, Hirata H, Ueno K, Chang I, Tanaka Y, Gupta A, Dahiya R MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma. Carcinogenesis 2012, 33:294-300.
36. Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, et al. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 2011, 147:344-357.
37. Meijer HA, Kong YW, Lu WT, Wilczynska A, Spriggs RV, Robinson SW, Godfrey JD, Willis AE, Bushell M Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation. Science 2013, 340:82-85.
38. Song L, Dai T, Xie Y, Wang C, Lin C, Wu Z, Ying Z, Wu J, Li M, Li J Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair. J Mol Cell Biol 2012, 4:108-117.
39. Sood P, Krek A, Zavolan M, Macino G, Rajewsky N Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A 2006, 103:2746-2751.
40. Carroll AP, Tooney PA, Cairns MJ Context-specific microRNA function in developmental complexity. J Mol Cell Biol 2013, 5:73-84.
41. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005, 435:839-843.
42. Lee BK, Bhinge AA, Battenhouse A, McDaniell RM, Liu Z, Song L, Ni Y, Birney E, Lieb JD, Furey TS, et al. Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. Genome Res 2012, 22:9-24.
43. Gu TJ, Yi X, Zhao XW, Zhao Y, Yin JQ Alu-directed transcriptional regulation of some novel miRNAs. BMC Genomics 2009, 10:563.
44. Feschotte C Transposable elements and the evolution of regulatory networks. Nat Rev Genet 2008, 9:397-405.
45. Smalheiser NR, Torvik VI Alu elements within human mRNAs are probable microRNA targets. Trends Genet 2006, 22:532-536.
46. Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, et al. The landscape of somatic copy-number alteration across human cancers. Nature 2010, 463:899-905.
47. Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 2010, 18:11-22.
48. Guan Y, Kuo WL, Stilwell JL, Takano H, Lapuk AV, Fridlyand J, Mao JH, Yu M, Miller MA, Santos JL, et al. Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res 2007, 13:5745-5755.