High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits

Structure

Volumn 24, Issue 8, 2016, Pages 1398-1409

  Schiebel, Johannes ^a   Krimmer, Stefan G ^a   Röwer, Karine ^b   Knörlein, Anna ^a   Wang, Xiaojie ^a   Park, Ah Young ^a   Stieler, Martin ^a   Ehrmann, Frederik R ^a   Fu, Kan ^a   Radeva, Nedyalka ^a   Krug, Michael ^b   Huschmann, Franziska U ^a,b   Glöckner, Steffen ^a   Weiss, Manfred S ^b   Mueller, Uwe ^b,c   Klebe, Gerhard ^a   Heine, Andreas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HAHN MEITNER INSTITUT   (Germany)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

SOLVENT; WATER; MOLECULAR LIBRARY;

ARTICLE; AUTOMATION; BINDING SITE; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DATA ANALYSIS; DIFFRACTION; DRUG DEVELOPMENT; DRUG STRUCTURE; FRAGMENT BASED LEAD DISCOVERY; HIGH THROUGHPUT SCREENING; MOLECULE; PRIORITY JOURNAL; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; CHEMISTRY; DRUG DESIGN; HUMAN; INFORMATION PROCESSING; MOLECULAR LIBRARY; PROCEDURES; STATISTICS AND NUMERICAL DATA;

CRYSTALLOGRAPHY, X-RAY; DATASETS AS TOPIC; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; SMALL MOLECULE LIBRARIES; WATER; X-RAY DIFFRACTION;

EID: 84979966787     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2016.06.010     Document Type: Article

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