Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library

Acta Crystallographica Section F:Structural Biology Communications

Volumn 72, Issue , 2016, Pages 346-355

  Huschmann, Franziska U ^a,b   Linnik, Janina ^a   Sparta, Karine ^a   Ühlein, Monika ^a   Wang, Xiaojie ^b   Metz, Alexander ^b   Schiebel, Johannes ^b   Heine, Andreas ^b   Klebe, Gerhard ^b   Weiss, Manfred S ^a   Mueller, Uwe ^a  

^a HAHN MEITNER INSTITUT   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

fragment screening; medicinal chemistry; protein ligand structures; structural biology; X ray crystallography

Indexed keywords

ASPARTIC PROTEINASE; ENDOTHIAPEPSIN; PEPTIDE FRAGMENT; PROTEIN BINDING;

CALORIMETRY; CHEMISTRY; PROTEIN CONFORMATION; VALIDATION STUDY; X RAY CRYSTALLOGRAPHY;

ASPARTIC ACID ENDOPEPTIDASES; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84969211396     PISSN: None     EISSN: 2053230X     Source Type: Journal    
DOI: 10.1107/S2053230X16004623     Document Type: Article

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