Hitting the target: Fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes

Acta Crystallographica Section D: Biological Crystallography

Volumn 70, Issue 5, 2014, Pages 1177-1189

  Yin, Xingyu ^a,b,c   Scalia, Alexander ^a,d   Leroy, Ludmila ^a,e,f   Cuttitta, Christina M ^a,g   Polizzo, Gina M ^a,h   Ericson, Daniel L ^a,i   Roessler, Christian G ^a   Campos, Olven ^a,j   Ma, Millie Y ^a,k   Agarwal, Rakhi ^a   Jackimowicz, Rick ^a   Allaire, Marc ^a   Orville, Allen M ^a   Sweet, Robert M ^a   Soares, Alexei S ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c NANJING UNIVERSITY   (China)

^d BINGHAMTON UNIVERSITY   (United States)

^e MINISTRY OF EDUCATION OF BRAZIL   (Brazil)

^f FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^g CITY UNIVERSITY OF NEW YORK   (United States)

^h St Joseph's College New York   (United States)

ⁱ University at Buffalo The State University of New York   (United States)

^j FLORIDA ATLANTIC UNIVERSITY   (United States)

^k Department of Biological Science Florida Atlantic University ^*  (United States)

more..

Author keywords

acoustic droplet ejection; chemical biology; drug discovery; fragment screening; in situ X ray data collection; protein crystallization; synchrotron radiation

Indexed keywords

LYSOZYME; MOLECULAR LIBRARY; PROTEIN; THERMOLYSIN; TRYPSIN;

ACOUSTICS; CHEMISTRY; CRYSTALLIZATION; DEVICES; DRUG DEVELOPMENT; EQUIPMENT DESIGN; MOLECULAR LIBRARY; PROCEDURES; X RAY CRYSTALLOGRAPHY;

ACOUSTICS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; EQUIPMENT DESIGN; MURAMIDASE; PROTEINS; SMALL MOLECULE LIBRARIES; THERMOLYSIN; TRYPSIN;

EID: 84900398916     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004713034603     Document Type: Article

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