How well can fragments explore accessed chemical space? A case study from heat shock protein 90

Journal of Medicinal Chemistry

Volumn 54, Issue 12, 2011, Pages 3989-4005

  Roughley, Stephen D ^a   Hubbard, Roderick E ^a,b  

^a Vernalis PLC   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 (2,4 DIHYDROXY 5 ISOPROPYLPHENYL) 4 (4 MORPHOLINOMETHYLPHENYL) 3 ISOXAZOLECARBOXYLIC ACID ETHYLAMIDE; ALVESPIMYCIN; AT 13387; BENZAMIDE DERIVATIVE; CNF 1010; CUDC 305; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; IPI 493; NVP BEP 800; RESORCINOL; RETASPIMYCIN; SNX 2112; SNX 5422; TANESPIMYCIN; UNCLASSIFIED DRUG;

CRYSTAL STRUCTURE; DRUG STRUCTURE; REVIEW;

BINDING SITES; DRUG DESIGN; DRUG DISCOVERY; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959407930     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200350g     Document Type: Review

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