Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles

Science Advances

Volumn 2, Issue 5, 2016, Pages

  Pakulska, Malgosia M ^a,b   Donaghue, Irja Elliott ^a,b   Obermeyer, Jaclyn M ^a,b   Tuladhar, Anup ^b   McLaughlin, Christopher K ^a   Shendruk, Tyler N ^c   Shoichet, Molly S ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DELIVERY; ELECTROSTATICS; ENCAPSULATION; FUNCTIONAL POLYMERS; NANOPARTICLES; PROTEINS; TARGETED DRUG DELIVERY;

ADSORPTION OF PROTEINS; CLINICAL TRANSLATION; ELECTROSTATIC ADSORPTION; ENCAPSULATION EFFICIENCY; NANOPARTICLE CONCENTRATIONS; POLY(LACTIC-CO-GLYCOLIC ACID); PROTEIN ENCAPSULATION; THERAPEUTIC MOLECULES;

CONTROLLED DRUG DELIVERY;

BRAIN DERIVED NEUROTROPHIC FACTOR; DELAYED RELEASE FORMULATION; DRUG CARRIER; LACTIC ACID; NANOPARTICLE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; PROTEIN;

ADSORPTION; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; MONTE CARLO METHOD; PH; STATIC ELECTRICITY;

ADSORPTION; BRAIN-DERIVED NEUROTROPHIC FACTOR; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MONTE CARLO METHOD; NANOPARTICLES; POLYGLYCOLIC ACID; PROTEINS; STATIC ELECTRICITY;

EID: 84979945616     PISSN: None     EISSN: 23752548     Source Type: Journal    
DOI: 10.1126/sciadv.1600519     Document Type: Article

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