Mathematical modelling of the evolution of protein distribution within single PLGA microspheres: Prediction of local concentration profiles and release kinetics

Journal of Materials Science: Materials in Medicine

Volumn 19, Issue 4, 2008, Pages 1587-1593

  Mollica, Francesco ^a   Biondi, Marco ^b   Muzzi, Sara ^a   Ungaro, Francesca ^b   Quaglia, Fabiana ^b   La Rotonda, Maria Immacolata ^b   Netti, Paolo Antonio ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BIODEGRADABILITY; KINETICS; MATHEMATICAL MODELS; MICROSPHERES; POLYMER MATRIX; SCANNING ELECTRON MICROSCOPY;

BOVINE SERUM ALBUMIN; RELEASE KINETICS; TETRAMETHYLRHODAMINE;

PROTEINS;

BOVINE SERUM ALBUMIN; MICROSPHERE; POLYGLACTIN; POLYMER; TETRAMETHYLRHODAMINE;

CONFERENCE PAPER; CONFOCAL LASER MICROSCOPY; EVOLUTION; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SCANNING ELECTRON MICROSCOPY;

ALGORITHMS; ANIMALS; CATTLE; COMPUTER SIMULATION; KINETICS; LACTIC ACID; MATERIALS TESTING; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MODELS, THEORETICAL; POLYGLYCOLIC ACID; POLYMERS; PROTEINS; RHODAMINES; SERUM ALBUMIN, BOVINE;

BOVINAE;

EID: 40949104888     PISSN: 09574530     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10856-007-3301-5     Document Type: Conference Paper

References (25)

1. M. C. PETERS, B. C. ISENBERG, J. A. ROWLEY, D. J. MOONEY, J. Biomater. Sci. Polym. Ed. 9 (1998) 1267
2. T. A. HOLLAND, A. G. MIKOS, Adv. Biochem. Eng. Biotechnol. 102 (2006) 161
3. F. UNGARO, M. BIONDI, L. INDOLFI, G. DE ROSA M. I. LA ROTONDA, F. QUAGLIA, P.A. NETTI (2005) Bioactivated Polymer Scaffolds for Tissue Engineering. In Topics in Tissue engineering Vol. II, edited by N. ASHAMMAKHI, R. L. RISE and W. SUN
4. D. F. LAZAROUS, M. SHOU, M. SCHEINOWITZ, E. HODGE, V. THIRUMURTI, A. N. KITSIOU, Circulation 94 (1996) 1074
5. N. FERRARA, H. P. GERBER, J. LECOUTER, Nat. Med. 9 (2003) 669
6. C. L. HELM, M. E. FLEURY, A. H. ZISCH, F. BOSCHETTI, M. A. SWARTZ, Proc. Natl. Acad. Sci. USA 102 (2005) 15779
7. H. GERHARDT, M. GOLDING, M. FRUTTIGER, C. RUHRBERG, A. LUNDKVIST, A. ABRAMSON, J. Cell. Biol. 161 (2003) 1163
8. J. ELISSEEFF, W. MCINTOSH, K. ANSETH, S. RILEY, P. RAGAN, R. LANGER, J. Biomed. Mater. Res. 51 (2000) 164
9. T. P. RICHARDSON, M. C. PETERS, A. B. ENNETT, D. J. MOONEY, Nat. Biotechnol. 19 (2001) 1029
10. A. PERETS, Y. BARUCH, F. WEISBUCH, G. SHOSHANY, G. NEUFELD, S. COHEN, J. Biomed. Mater. Res. 65A (2003) 489
11. F. UNGARO, M. BIONDI, I. D'ANGELO, L. INDOLFI, F. QUAGLIA, P. A. NETTI, M. I. LA ROTONDA, J. Control. Release 113 (2006) 128
12. R.P. BATYCKY, J. HANES, R. LANGER, D. A. EDWARDS, J. Pharm. Sci. 86 (1997) 1464
13. V. LEMAIRE, J. BELAIR, P. HILDGEN, Int. J. Pharm. 258 (2003) 95
14. N. FAISANT, J. SIEPMANN, J. P. BENOIT, Eur. J. Pharm. Sci. 15 (2002) 355
15. N. FAISANT, J. SIEPMANN, J. RICHARD, J. P. BENOIT, Eur. J. Pharmaceut. Biopharmaceut. 56 (2003) 271
16. J. HE, C. ZHONG, J. MI, Drug Deliv. 12 (2005) 251
17. M. ZHANG, Z. YANG, L. L. CHOW, C. H. WANG, J. Pharm. Sci. 92 (2003) 2040
18. G. CROTTS, T. G. PARK, J. Microencapsul. 15 (1998) 699
19. H. OKADA, H. TOGUCHI, Crit. Rev. Ther. Drug Carrier Syst. 12 (1995) 1
20. T.G. PARK, Biomaterials 16 (1995) 1123
21. I. GRIZZI, H. GARREAU, S. LI, M. VERT, Biomaterials 16 (1995) 305
22. F. VON BURKERSRODA, L. SCHEDL, A. GÖPFERICH, Biomaterials 23 (2002) 4221
23. J. SIEPMANN, K. ELKHARRAZ, F. SIEPMANN, D. KLOSE, Biomacromolecules 6 (2005) 2312
24. J. N. REDDY, in "Introduction to the Finite Element Method" (McGraw Hill, 1993) 228
25. J. KANG, S. P. SCHWENDEMAN, Mol. Pharm. 4 (2007) 104