Chemical and spatial analysis of protein loaded PLGA microspheres for drug delivery applications

Journal of Controlled Release

Volumn 162, Issue 2, 2012, Pages 321-329

  Rafati, A ^a   Boussahel, A ^a   Shakesheff, K M ^a   Shard, A G ^b   Roberts, C J ^a   Chen, X ^a   Scurr, D J ^a   Rigby Singleton, S ^c   Whiteside, P ^c   Alexander, M R ^a   Davies, M C ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NATIONAL PHYSICAL LABORATORY   (United Kingdom)

^c Molecular Profiles Ltd   (United Kingdom)

Author keywords

Confocal Raman; Microsphere; Protein; Surface analysis; Surfactant; ToF SIMS

Indexed keywords

BULK ANALYSIS; BULK PROPERTIES; BURST RELEASE; CONFOCAL RAMAN; CONTROLLED RELEASE; DISCONTINUOUS FILMS; DRUG DELIVERY APPLICATIONS; OIL PHASE; OPTIMISATIONS; PLGA MICROSPHERES; POLY LACTIC-CO-GLYCOLIC ACID; POLYMER MICROSPHERES; POLYVINYL ALCOHOL (PVA); RELEASE PROFILES; SPATIAL ANALYSIS; SURFACE PORES; SURFACE PROTEINS; THERAPEUTIC EFFECTS; THERAPEUTIC PROTEIN; TIME OF FLIGHT; TOF SIMS;

ATOMIC FORCE MICROSCOPY; DRUG DELIVERY; LUNAR SURFACE ANALYSIS; MICROSPHERES; OPTIMIZATION; ORGANIC POLYMERS; SCANNING ELECTRON MICROSCOPY; SECONDARY ION MASS SPECTROMETRY; SURFACE ACTIVE AGENTS; SURFACE ANALYSIS;

PROTEINS;

MICROSPHERE; POLYGLACTIN; POLYVINYL ALCOHOL;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL ANALYSIS; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; MASS SPECTROMETRY; MOLECULAR PROBE; PARTICLE SIZE; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; THICKNESS; TIME OF FLIGHT MASS SPECTROMETRY;

DRUG CARRIERS; LACTIC ACID; MICROSPHERES; MURAMIDASE; POLYGLYCOLIC ACID; POLYVINYL ALCOHOL; POROSITY; SPATIAL ANALYSIS; SPECTROMETRY, MASS, SECONDARY ION; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS;

EID: 84865308705     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.008     Document Type: Article

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