메뉴 건너뛰기




Volumn 5, Issue 7, 2015, Pages 768-881

Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR; INITIATION FACTOR 4A; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; ANTINEOPLASTIC AGENT; INITIATION FACTOR 4E; MYC PROTEIN; MYC PROTEIN, HUMAN; SILVESTROL; TRITERPENE;

EID: 84979837852     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-14-1040     Document Type: Article
Times cited : (90)

References (44)
  • 2
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-7.
    • (2012) Nature , vol.487 , pp. 330-337
  • 5
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011; 146: 904-17.
    • (2011) Cell , vol.146 , pp. 904-917
    • Delmore, J.E.1    Issa, G.C.2    Lemieux, M.E.3    Rahl, P.B.4    Shi, J.5    Jacobs, H.M.6
  • 6
    • 0142057146 scopus 로고    scopus 로고
    • Low molecular weight inhibitors of Myc-Max interaction and function
    • Yin X, Giap C, Lazo JS, Prochownik EV. Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 2003; 22: 6151-9.
    • (2003) Oncogene , vol.22 , pp. 6151-6159
    • Yin, X.1    Giap, C.2    Lazo, J.S.3    Prochownik, E.V.4
  • 7
    • 84918519265 scopus 로고    scopus 로고
    • Tumor cell-specifi c inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
    • Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Muller J, et al. Tumor cell-specifi c inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. EMBO Mol Med 2014; 6: 1525-41.
    • (2014) EMBO Mol Med , vol.6 , pp. 1525-1541
    • Peter, S.1    Bultinck, J.2    Myant, K.3    Jaenicke, L.A.4    Walz, S.5    Muller, J.6
  • 11
    • 33748068792 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
    • Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, et al. Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma. Cancer Res 2006; 66: 8139-46.
    • (2006) Cancer Res , vol.66 , pp. 8139-8146
    • Chesler, L.1    Schlieve, C.2    Goldenberg, D.D.3    Kenney, A.4    Kim, G.5    McMillan, A.6
  • 12
    • 80052490834 scopus 로고    scopus 로고
    • Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms
    • Liu P, Cheng H, Santiago S, Raeder M, Zhang F, Isabella A, et al. Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms. Nat Med 2011; 17: 1116-20.
    • (2011) Nat Med , vol.17 , pp. 1116-1120
    • Liu, P.1    Cheng, H.2    Santiago, S.3    Raeder, M.4    Zhang, F.5    Isabella, A.6
  • 15
    • 80054845323 scopus 로고    scopus 로고
    • Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma
    • Schatz JH, Oricchio E, Wolfe AL, Jiang M, Linkov I, Maragulia J, et al. Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. J Exp Med 2011; 208: 1799-807.
    • (2011) J Exp Med , vol.208 , pp. 1799-1807
    • Schatz, J.H.1    Oricchio, E.2    Wolfe, A.L.3    Jiang, M.4    Linkov, I.5    Maragulia, J.6
  • 16
    • 51049109033 scopus 로고    scopus 로고
    • Identifi cation and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, et al. Identifi cation and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008; 7: 1851-63.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3    Furet, P.4    Schnell, C.5    Fritsch, C.6
  • 17
    • 46749097944 scopus 로고    scopus 로고
    • Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
    • Bordeleau ME, Robert F, Gerard B, Lindqvist L, Chen SM, Wendel HG, et al. Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest 2008; 118: 2651-60.
    • (2008) J Clin Invest , vol.118 , pp. 2651-2660
    • Bordeleau, M.E.1    Robert, F.2    Gerard, B.3    Lindqvist, L.4    Chen, S.M.5    Wendel, H.G.6
  • 18
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV. MYC on the path to cancer. Cell 2012; 149: 22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 19
    • 0028009754 scopus 로고
    • Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1
    • Roussel MF, Davis JN, Cleveland JL, Ghysdael J, Hiebert SW. Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1. Oncogene 1994; 9: 405-15.
    • (1994) Oncogene , vol.9 , pp. 405-415
    • Roussel, M.F.1    Davis, J.N.2    Cleveland, J.L.3    Ghysdael, J.4    Hiebert, S.W.5
  • 21
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96: 857-68.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 22
    • 41849150779 scopus 로고    scopus 로고
    • FOXOs, cancer and regulation of apoptosis
    • Fu Z, Tindall DJ. FOXOs, cancer and regulation of apoptosis. Oncogene 2008; 27: 2312-9.
    • (2008) Oncogene , vol.27 , pp. 2312-2319
    • Fu, Z.1    Tindall, D.J.2
  • 23
    • 0042161896 scopus 로고    scopus 로고
    • Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway
    • Puig O, Marr MT, Ruhf ML, Tjian R. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev 2003; 17: 2006-20.
    • (2003) Genes Dev , vol.17 , pp. 2006-2020
    • Puig, O.1    Marr, M.T.2    Ruhf, M.L.3    Tjian, R.4
  • 24
    • 20044380423 scopus 로고    scopus 로고
    • The eukaryotic initiation factor 4E-binding proteins and apoptosis
    • Proud CG. The eukaryotic initiation factor 4E-binding proteins and apoptosis. Cell Death Differ 2005; 12: 541-6.
    • (2005) Cell Death Differ , vol.12 , pp. 541-546
    • Proud, C.G.1
  • 25
    • 84880614734 scopus 로고    scopus 로고
    • The insulin receptor cellular IRES confers resistance to eIF4A inhibition
    • Olson CM, Donovan MR, Spellberg MJ, Marr MT 2nd. The insulin receptor cellular IRES confers resistance to eIF4A inhibition. eLife 2013; 2: e00542.
    • (2013) Elife , vol.2
    • Olson, C.M.1    Donovan, M.R.2    Spellberg, M.J.3    Marr, M.T.4
  • 27
  • 28
    • 84855855153 scopus 로고    scopus 로고
    • Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: Synthetic and biological studies
    • Rodrigo CM, Cencic R, Roche SP, Pelletier J, Porco JA. Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. J Med Chem 2012; 55: 558-62
    • (2012) J Med Chem , vol.55 , pp. 558-562
    • Rodrigo, C.M.1    Cencic, R.2    Roche, S.P.3    Pelletier, J.4    Porco, J.A.5
  • 29
    • 18644373146 scopus 로고    scopus 로고
    • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002; 111: 241-50.
    • (2002) Cell , vol.111 , pp. 241-250
    • van De Wetering, M.1    Sancho, E.2    Verweij, C.3    de Lau, W.4    Oving, I.5    Hurlstone, A.6
  • 30
    • 84920944681 scopus 로고    scopus 로고
    • Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation
    • Rubio CA, Weisburd B, Holderfi eld M, Arias C, Fang E, DeRisi JL, et al. Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation. Genome Biol 2014; 15: 476.
    • (2014) Genome Biol , vol.15 , pp. 476
    • Rubio, C.A.1    Weisburd, B.2    Holderfi Eld, M.3    Arias, C.4    Fang, E.5    Derisi, J.L.6
  • 31
    • 84875748565 scopus 로고    scopus 로고
    • Identifi cation of cardiac glycoside molecules as inhibitors of c-Myc IRES-mediated translation
    • Didiot MC, Hewett J, Varin T, Freuler F, Selinger D, Nick H, et al. Identifi cation of cardiac glycoside molecules as inhibitors of c-Myc IRES-mediated translation. J Biomol Screen 2013; 18: 407-19.
    • (2013) J Biomol Screen , vol.18 , pp. 407-419
    • Didiot, M.C.1    Hewett, J.2    Varin, T.3    Freuler, F.4    Selinger, D.5    Nick, H.6
  • 32
    • 35248889933 scopus 로고    scopus 로고
    • Loss of programmed cell death 4 expression marks adenomacarcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer
    • Mudduluru G, Medved F, Grobholz R, Jost C, Gruber A, Leupold JH, et al. Loss of programmed cell death 4 expression marks adenomacarcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer. Cancer 2007; 110: 1697-707.
    • (2007) Cancer , vol.110 , pp. 1697-1707
    • Mudduluru, G.1    Medved, F.2    Grobholz, R.3    Jost, C.4    Gruber, A.5    Leupold, J.H.6
  • 33
    • 84878889056 scopus 로고    scopus 로고
    • ROS production and NF-kappaB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation
    • Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, et al. ROS production and NF-kappaB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell 2013; 12: 761-73.
    • (2013) Cell Stem Cell , vol.12 , pp. 761-773
    • Myant, K.B.1    Cammareri, P.2    McGhee, E.J.3    Ridgway, R.A.4    Huels, D.J.5    Cordero, J.B.6
  • 34
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378: 785-9.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Jelkovich, M.4    Hemmings, B.A.5
  • 35
    • 60149085428 scopus 로고    scopus 로고
    • The aurora kinase A regulates GSK- 3beta in gastric cancer cells
    • Dar AA, Belkhiri A, El-Rifai W. The aurora kinase A regulates GSK- 3beta in gastric cancer cells. Oncogene 2009; 28: 866-75.
    • (2009) Oncogene , vol.28 , pp. 866-875
    • Dar, A.A.1    Belkhiri, A.2    El-Rifai, W.3
  • 36
    • 0027960448 scopus 로고
    • Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation
    • Stambolic V, Woodgett JR. Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. Biochem J 1994; 303 (Pt 3): 701-4.
    • (1994) Biochem J , vol.303 , pp. 701-704
    • Stambolic, V.1    Woodgett, J.R.2
  • 37
    • 57749187631 scopus 로고    scopus 로고
    • Suppression of Myc oncogenic activity by ribosomal protein haploinsuffi ciency
    • Barna M, Pusic A, Zollo O, Costa M, Kondrashov N, Rego E, et al. Suppression of Myc oncogenic activity by ribosomal protein haploinsuffi ciency. Nature 2008; 456: 971-5.
    • (2008) Nature , vol.456 , pp. 971-975
    • Barna, M.1    Pusic, A.2    Zollo, O.3    Costa, M.4    Kondrashov, N.5    Rego, E.6
  • 38
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev 2009; 10: 307-18.
    • (2009) Nat Rev , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 39
    • 84880352272 scopus 로고    scopus 로고
    • Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
    • Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A 2013; 110: 11988-93.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 11988-11993
    • Pourdehnad, M.1    Truitt, M.L.2    Siddiqi, I.N.3    Ducker, G.S.4    Shokat, K.M.5    Ruggero, D.6
  • 40
    • 84925491509 scopus 로고    scopus 로고
    • MTORC1-mediated translational elongation limits intestinal tumour initiation and growth
    • Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, et al. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature 2015; 517: 497-500.
    • (2015) Nature , vol.517 , pp. 497-500
    • Faller, W.J.1    Jackson, T.J.2    Knight, J.R.3    Ridgway, R.A.4    Jamieson, T.5    Karim, S.A.6
  • 42
    • 78049439594 scopus 로고    scopus 로고
    • Role of the amino terminal RHAU-specifi c motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU
    • Lattmann S, Giri B, Vaughn JP, Akman SA, Nagamine Y. Role of the amino terminal RHAU-specifi c motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU. Nucleic Acids Res 2010; 38: 6219-33.
    • (2010) Nucleic Acids Res , vol.38 , pp. 6219-6233
    • Lattmann, S.1    Giri, B.2    Vaughn, J.P.3    Akman, S.A.4    Nagamine, Y.5
  • 43
    • 78049286314 scopus 로고    scopus 로고
    • Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability
    • Skrzypczak M, Goryca K, Rubel T, Paziewska A, Mikula M, Jarosz D, et al. Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS One 2010; 5.
    • (2010) Plos One , pp. 5
    • Skrzypczak, M.1    Goryca, K.2    Rubel, T.3    Paziewska, A.4    Mikula, M.5    Jarosz, D.6
  • 44
    • 70349616273 scopus 로고    scopus 로고
    • Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
    • Balgi AD, Fonseca BD, Donohue E, Tsang TC, Lajoie P, Proud CG, et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 2009; 4: e7124.
    • (2009) Plos One , vol.4
    • Balgi, A.D.1    Fonseca, B.D.2    Donohue, E.3    Tsang, T.C.4    Lajoie, P.5    Proud, C.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.