Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

Cell Reports

Volumn 16, Issue 6, 2016, Pages 1614-1628

  Padanad, Mahesh S ^a,b   Konstantinidou, Georgia ^a,b   Venkateswaran, Niranjan ^a,b   Melegari, Margherita ^b   Rindhe, Smita ^a,b   Mitsche, Matthew ^a,c   Yang, Chendong ^c   Batten, Kimberly ^c   Huffman, Kenneth E ^c   Liu, Jingwen ^d   Tang, Ximing ^e   Rodriguez Canales, Jaime ^e   Kalhor, Neda ^e   Shay, Jerry W ^c   Minna, John D ^a,c   McDonald, Jeffrey ^a   Wistuba, Ignacio I ^e   DeBerardinis, Ralph J ^c   Scaglioni, Pier Paolo ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

ACSL3; cancer metabolism; fatty acid oxidation; lipid metabolism; lung cancer; mouse cancer models; mutant KRAS

Indexed keywords

ACYL COENZYME A SYNTHETASE LONG CHAIN FAMILY MEMBER 3; LONG CHAIN FATTY ACID COENZYME A LIGASE; UNCLASSIFIED DRUG; ACYL COENZYME A; COENZYME A LIGASE; FATTY ACID; KRAS PROTEIN, HUMAN; KRAS2 PROTEIN, MOUSE; LIGASE; LONG-CHAIN-FATTY-ACID-COA LIGASE; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GRADING; CELL LOSS; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; GENE EXPRESSION; GLYCOLYSIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIPOGENESIS; LUNG CARCINOGENESIS; LUNG TUMOR; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; ANIMAL; CARCINOGENESIS; CELL TRANSFORMATION; GENETICS; KNOCKOUT MOUSE; LIPID METABOLISM; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

ACYL COENZYME A; ANIMALS; CARCINOGENESIS; CELL TRANSFORMATION, NEOPLASTIC; COENZYME A LIGASES; FATTY ACIDS; HUMANS; LIGASES; LIPID METABOLISM; LIPOGENESIS; LUNG NEOPLASMS; MICE, KNOCKOUT; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 84979738962     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.07.009     Document Type: Article

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