Size-exclusive effect of nanostructured lipid carriers on oral drug delivery

International Journal of Pharmaceutics

Volumn 511, Issue 1, 2016, Pages 524-537

  Li, Huipeng ^a   Chen, Minglei ^a   Su, Zhigui ^a   Sun, Minjie ^a   Ping, Qineng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Caco 2 cell; Intestinal absorption; Nanostructured lipid carriers; Oral drug delivery; Particle size; Pharmacokinetics

Indexed keywords

CLATHRIN; COUMARIN 6; COUMARIN DERIVATIVE; LIPID; NANOCARRIER; NANOSTRUCTURED LIPID CARRIER; SOLVENT; UNCLASSIFIED DRUG; DRUG CARRIER; NANOMATERIAL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CACO 2 CELL LINE; CAVEOLA; CELL MEMBRANE TRANSPORT; CHEMICAL STRUCTURE; CIRCULATION; COLON; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DUODENUM; ENDOCYTOSIS; EVAPORATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; ILEUM; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE LOOP; INTESTINE MUCOSA PERMEABILITY; JEJUNUM; MALE; MAXIMUM PLASMA CONCENTRATION; MONOLAYER CULTURE; MOUSE; MTT ASSAY; NANOFABRICATION; NANOPHARMACEUTICS; NANOTOXICOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; CACO-2 CELL LINE; CHEMISTRY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PHYSIOLOGY; PIG; PROCEDURES; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; INTESTINAL ABSORPTION; LIPIDS; MALE; MICE; MICE, INBRED ICR; NANOSTRUCTURES; PARTICLE SIZE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SWINE;

EID: 84979645442     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.07.049     Document Type: Article

References (40)

1. Albanese, C.T., Cardona, M., Smith, S.D., Watkins, S., Kurkchubasche, A.G., Ulman, I., Simmons, R.L., Rowe, M.I., Role of intestinal mucus in transepithelial passage of bacteria across the intact ileum in vitro. Surgery 116 (1994), 76–82.
2. Baos, S.C., Phillips, D.B., Wildling, L., Mcmaster, T.J., Berry, M., Distribution of sialic acids on mucins and gels: a defense mechanism. Biophys. J. 102 (2012), 176–184.
3. Beloqui, A., Gascón, A.R., Pozo-Rodríguez, A.D., Rieux, A.D., Préat, V., Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier. J. Control. Release 166 (2013), 115–123.
4. Chen, D., Xia, D., Li, X., Zhu, Q., Yu, H., Zhu, C., Gan, Y., Comparative study of Pluronic(®) F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats. Int. J. Pharm. 449 (2013), 1–9.
5. Conner, S.D., Schmid, S.L., Regulated portals of entry into the cell. Nature 422 (2003), 37–44.
6. Doktorovova, S., Souto, E.B., Silva, A.M., Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers – a systematic review of in vitro data. Eur. J. Pharm. Biopharm. 87 (2014), 1–18.
7. Ensign, L.M., Cone, R., Hanes, J., Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv. Drug Deliv. Rev. 64 (2012), 557–570.
8. Florey, H.W., The secretion and function of intestinal mucus. Gastroenterology 43 (1962), 326–329.
9. Gao, F., Zhang, Z., Bu, H., Huang, Y., Gao, Z., Shen, J., Zhao, C., Li, Y., Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: performance and mechanism. J. Control. Release 149 (2011), 168–174.
10. Gruber, P., Longer, M.A., Robinson, J.R., Some biological issues in oral, controlled drug delivery. Adv. Drug Deliv. Rev. 1 (1988), 1–18.
11. He, C., Yin, L., Tang, C., Yin, C., Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs. Biomaterials 33 (2012), 8569–8578.
12. Jani, P., Halbert, G.W., Langridge, J., Florence, A.T., The uptake and translocation of latex nanospheres and microspheres after oral administration to rats. J. Pharm. Pharmacol. 41 (1989), 809–812.
13. Jani, P., Halbert, G.W., Langridge, J., Florence, A.T., Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 42 (1990), 821–826.
14. Jung, T., Kamm, W., Breitenbach, A., Kaiserling, E., Xiao, J.X., Kissel, T., Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?. Eur. J. Pharm. Biopharm. 50 (2000), 147–160.
15. Kammona, O., Kiparissides, C., Recent advances in nanocarrier-based mucosal delivery of biomolecules. J. Control. Release 161 (2012), 781–794.
16. Khato, J., Priester, E.R., Sieber, S.M., Enhanced lymph node uptake of melphalan following liposomal entrapment and effects on lymph node metastasis in rats. Cancer Treat. Rep. 66 (1982), 517–527.
17. Li, C.J., Yu, Y.L., Yang, Q.M., Li, Y., Zhang, Y.H., Wang, J.Y., [Optimization of the formulation of ranolazine hydrochloride sustained-release tablet and its pharmacokinetics in dogs]. Yao xue bao 45 (2010), 1170–1176.
18. Li, H., Xiao, Y., Niu, J., Chen, X., Ping, Q., Preparation of a cationic nanoemulsome for intratumoral drug delivery and its enhancing effect on cellular uptake in vitro. J. Nanosci. Nanotechnol. 11 (2011), 8547–8555.
19. Li, M.H., Kantanen, J., Michelson, A., Saarma, U., Genetic components of grey cattle in Estonia as revealed by microsatellite analysis using two Bayesian clustering methods. BMC Res. Notes 4 (2011), 1–6.
20. Li, X., Guo, S., Zhu, C., Zhu, Q., Gan, Y., Rantanen, J., Rahbek, U.L., Hovgaard, L., Yang, M., Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles. Biomaterials 34 (2013), 9678–9687.
21. Macadam, A., The effect of gastro-intestinal mucus on drug absorption. Adv. Drug Deliv. Rev. 11 (1993), 201–220.
22. Mathot, F., Rieux, A.D., Ariën, A., Schneider, Y.J., Brewster, M., Préat, V., Transport mechanisms of mmePEG 750 P(CL-co-TMC) polymeric micelles across the intestinal barrier. J. Control. Release 124 (2007), 134–143.
23. Muchow, M., Maincent, P., Müller, R.H., Keck, C.M., 2013. Testosterone undecanoate – increase of oral bioavailability by nanostructured lipid carriers (NLC). 2.
24. Muller, R.H., Radtke, M., Wissing, S.A., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev. 54:Suppl. 1 (2002), S131–155.
25. Primard, C., Rochereau, N., Luciani, E., Genin, C., Delair, T., Paul, S., Verrier, B., Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells. Biomaterials 31 (2010), 6060–6068.
26. Rejman, J., Oberle VZuhorn, I.S., Hoekstra, D., Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis. Biochem. J 377 (2004), 159–169.
27. Rieux, A.D., Fievez, V., Garinot, M., Schneider, Y.J., Préat, V., Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J. Control. Release 116 (2006), 1–27.
28. Rieux, A.D., Fievez, V., Théate, I., Mast, J., Préat, V., Schneider, Y.J., An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells. Eur. J. Pharm. Sci. 30 (2007), 380–391.
29. Rodal, S.K., Skretting, G., Garred, O., Vilhardt, F., Van, D.B., Sandvig, K., Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol. Biol. Cell 10 (1999), 961–974.
30. Saupe, A., Wissing, S.A., Lenk, A., Schmidt, C., Muller, R.H., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) – structural investigations on two different carrier systems. Biomed. Mater. Eng. 15 (2005), 393–402.
31. Schenk, M., Mueller, C., The mucosal immune system at the gastrointestinal barrier. Best Pract. Res. Clin. Gastroenterol. 22 (2008), 391–409.
32. Severino, P., Pinho, S.C., Souto, E.B., Santana, M.H.A., Crystallinity of Dynasan (R) 114 and Dynasan (R) 118 matrices for the production of stable miglyol (R)-loaded nanoparticles. J. Therm. Anal. Calorim. 108 (2012), 101–108.
33. Shi, Y., Su, Z., Li, S., Chen, Y., Chen, X., Xiao, Y., Sun, M., Ping, Q., Zong, L., Multistep targeted nano drug delivery system aiming at leukemic stem cells and minimal residual disease. Mol. Pharm. 10 (2013), 2479–2489.
34. Silva, A.C., Kumar, A., Wild, W., Ferreira, D., Santos, D., Forbes, B., Long-term stability, biocompatibility and oral delivery potential of risperidone-loaded solid lipid nanoparticles. Int. J. Pharm. 436 (2012), 798–805.
35. Su, Z., Shi, Y., Xiao, Y., Sun, M., Ping, Q., Zong, L., Li, S., Niu, J., Huang, A., You, W., Chen, Y., Chen, X., Fei, J., Tian, J., Effect of octreotide surface density on receptor-mediated endocytosis in vitro and anticancer efficacy of modified nanocarrier in vivo after optimization. Int. J. Pharm. 447 (2013), 281–292.
36. Takeuchi, H., Thongborisute, J., Matsui, Y., Sugihara, H., Yamamoto, H., Kawashima, Y., Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems. Adv. Drug Deliv. Rev. 57 (2005), 1583–1594.
37. Thongborisute, J., Takeuchi, H., Evaluation of mucoadhesiveness of polymers by BIACORE method and mucin-particle method. Int. J. Pharm. 354 (2008), 204–209.
38. Xie, Z., Ji, Z., Zhang, Z., Gong, T., Sun, X., Adenoviral vectors coated with cationic PEG derivatives for intravaginal vaccination against HIV-1. Biomaterials 35 (2014), 7896–7908.
39. Yang, L., Gao, S., Asghar, S., Liu, G., Song, J., Wang, X., Ping, Q., Zhang, C., Xiao, Y., Hyaluronic acid/chitosan nanoparticles for delivery of curcuminoid and its in vitro evaluation in glioma cells. Int. J. Biol. Macromol. 72 (2015), 1391–1401.
40. Yuan, H., Chen, C.Y., Chai, G.H., Du, Y.Z., Hu, F.Q., Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles. Mol. Pharm. 10 (2013), 1865–1873.