Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers

Journal of Controlled Release

Volumn 242, Issue , 2016, Pages 25-34

  Döge, Nadine ^a,b   Hönzke, Stefan ^b   Schumacher, Fabian ^c,d   Balzus, Benjamin ^b   Colombo, Miriam ^b   Hadam, Sabrina ^a   Rancan, Fiorenza ^a   Blume Peytavi, Ulrike ^a   Schäfer Korting, Monika ^b   Schindler, Anke ^b   Rühl, Eckart ^b   Skov, Per Stahl ^a,e   Church, Martin K ^a   Hedtrich, Sarah ^b   Kleuser, Burkhard ^c   Bodmeier, Roland ^b   Vogt, Annika ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF POTSDAM   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e RefLab   (Denmark)

Author keywords

Dexamethasone; Drug delivery systems; Microdialysis; Polymeric nanoparticles; Skin barrier disruption; Skin penetration

Indexed keywords

CELLULOSE; DIALYSIS; DIFFUSION BARRIERS; DRUG DOSAGE; DRUG PRODUCTS; NANOCRYSTALS; NANOPARTICLES; PROBES; SODIUM; SODIUM SULFATE;

DEXAMETHASONES; DRUG DELIVERY SYSTEM; MICRO-DIALYSIS; POLYMERIC NANOPARTICLES; SKIN PENETRATION;

SKIN;

DEXAMETHASONE; DODECYL SULFATE SODIUM; ETHYL CELLULOSE; GLUCOCORTICOID; INTERLEUKIN 6; INTERLEUKIN 8; NANOCARRIER; NANOCRYSTAL; TISSUE EXTRACT; ANTIINFLAMMATORY AGENT; CELLULOSE; CYTOKINE; DRUG CARRIER; NANOPARTICLE;

ARTICLE; CONTROLLED STUDY; CREAM; CULTURE MEDIUM; DERMIS; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; EPIDERMIS; EX VIVO STUDY; EXTRACT; EXTRACTION; FEMALE; HEAT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INJURY; MICRODIALYSIS; NANOENCAPSULATION; PRIORITY JOURNAL; SEPARATION TECHNIQUE; SKIN; SKIN CULTURE; SKIN PENETRATION; STRATUM CORNEUM; ANALOGS AND DERIVATIVES; CHEMISTRY; COMPARATIVE STUDY; CUTANEOUS DRUG ADMINISTRATION; METABOLISM; SKIN ABSORPTION; SKIN DISEASE; TIME FACTOR;

ADMINISTRATION, CUTANEOUS; ANTI-INFLAMMATORY AGENTS; CELLULOSE; CYTOKINES; DEXAMETHASONE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; FEMALE; GLUCOCORTICOIDS; HUMANS; MICRODIALYSIS; NANOPARTICLES; SKIN; SKIN ABSORPTION; SKIN DISEASES; SODIUM DODECYL SULFATE; TIME FACTORS;

EID: 84979581151     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.07.009     Document Type: Article

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