Targeted delivery of a poorly water-soluble compound to hair follicles using polymeric nanoparticle suspensions

International Journal of Pharmaceutics

Volumn 416, Issue 1, 2011, Pages 314-322

  Morgen, Michael ^a   Lu, Guang Wei ^b   Du, Daniel ^b,c   Stehle, Randall ^b,d   Lembke, Franz ^a   Cervantes, Jessica ^a   Ciotti, Susan ^b,e   Haskell, Roy ^b,f   Smithey, Dan ^a,g   Haley, Kevin ^a,d   Fan, Conglin ^b  

^a Bend Research Incorporated   (United States)

^b PFIZER INC   (United States)

^c GLAXOSMITHKLINE   (United States)

^d 5886 West Q Avenue ^*  (United States)

^e NanoBio Corporation   (United States)

^f BRISTOL MYERS SQUIBB   (United States)

^g Agere Pharmaceuticals   (United States)

Author keywords

Dermal; Hair follicles; Low solubility; Nanoparticles

Indexed keywords

4 (2,3 DIHYDRO 2 METHYL 3 OXO 6 PYRIDAZINYLOXY) 6 (3 HYDROXYPHENYLSULFONYL) 2,2,3 TRIMETHYL 3 CHROMANOL; ETHYL CELLULOSE; GLYCOCHOLATE SODIUM; NANOPARTICLE; POLYMER; POTASSIUM CHANNEL STIMULATING AGENT; PROPYLENE GLYCOL; STABILIZING AGENT; WATER;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; DRUG TOLERABILITY; DRUG TRANSPORT; HAIR FOLLICLE; HAIR GROWTH; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SEBACEOUS GLAND; SKIN IRRITATION; SUSPENSION;

ADMINISTRATION, CUTANEOUS; ANIMALS; BENZOPYRANS; CELLULOSE; CRICETINAE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; HAIR FOLLICLE; MICE; MICE, INBRED C3H; NANOPARTICLES; PARTICLE SIZE; POLYMERS; RABBITS; SEBACEOUS GLANDS; SOLUBILITY; SULFONES; SUSPENSIONS;

EID: 80051784389     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.06.019     Document Type: Article

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