A comparative study on the skin penetration of pure tryptanthrin and tryptanthrin in Isatis tinctoria extract by dermal microdialysis coupled with isotope dilution ESI-LC-MS

Planta Medica

Volumn 69, Issue 5, 2003, Pages 385-389

  Oberthür, Christine ^a   Heinemann, Christian ^a   Elsner, Peter ^a   Benfeldt, Eva ^b   Hamburger, Matthias ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ISATIS TINCTORIA EXTRACT; PLANT EXTRACT; TRYPTANTHRIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DERMIS; DIALYSATE; DRUG ACTIVITY; DRUG DIFFUSION; DRUG PENETRATION; DRUG PURITY; FORELIMB; HERB; HUMAN; ISATIS TINCTORIA; ISOTOPE DILUTION ASSAY; MASS SPECTROMETRY; MEDICINAL PLANT; MICRODIALYSIS; NONHUMAN; SKIN ELECTRODE; SKIN PENETRATION; SWINE;

ANIMALS; CHROMATOGRAPHY, LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ISATIS; MICRODIALYSIS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; QUINAZOLINES; SKIN; SKIN ABSORPTION; SWINE;

ANIMALIA; ISATIS; ISATIS TINCTORIA; SUS SCROFA;

EID: 0037757805     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-39718     Document Type: Article

References (17)

1. Hamburger M, Danz H. Medicament for inhibiting NF-κB. WO 00/61159.
2. Danz H, Stoyanova S, Hamburger M, Brattström A. Identification and isolation of the COX-2 inhibitory principle in Isatis tinctoria L. (Brassicaceae). Arch Pharm 2000; 333 (Suppl. 1 ): 11
3. Danz H, Stoyanova S, Wippich P, Brattström A, Hamburger M. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria. Planta Med 2001; 67: 411-6
4. Danz H, Baumann D, Hamburger M. Quantitative determination of the dual COX-2/5-LOX inhibitor tryptanthrin in Isatis tinctoria by ESI-LC-MS. Planta Med 2002; 68: 152-7
5. Danz H, Stoyanova S, Thomet O, Simon HU, Dannhardt G, Ulbrich H, Hamburger M. Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis. Planta Med 2002; 68: 875-80
6. 2 synthesis by murine macrophages. Eur J Pharmacol 2000; 407: 197-204
7. th Annual Congress of Society of Medicinal Plant Research 2002. Canigueral S, editor. Carlet (Valencia): CITA Publicaciones y Documentacion, 2002: p. 94
8. Heinemann C, Schliemann-Willers S, Oberthür C, Hamburger M, Elsner P. Prevention of experimentally induced irritant contact dermatitis by Isatis tinctoria and tryptanthrin and its impact on UVB-induced erythema. Brit J Dermatol, submitted,
9. Bronaugh RL, Maibach HI. editors. Topical Absorption of Dermatological Products. New York, Basel: Marcel Dekker, 2002
10. Anderson C, Anderson T, Molander M. Ethanol absorption across human skin measured by in vivo microdialysis technique. Acta Derm Venerol 1991; 71: 389-93
11. Benfeldt E. In vivo microdialysis for the investigation of drug levels in the dermis and the effect of barrier perturbation on cutaneous drug penetration. Studies in hairless rats and human subjects. Acta Derm Venereol 1999; 206 (Suppl): 1-59
12. Schnetz E, Fartasch M. Microdialysis for the evaluation of penetration through the human skin barrier - a promising tool for future research?. Eur J Pharm Sci 2000; 1: 1-9
13. Riviere JE, Monteiro-Riviere N, Williams P. Isolated perfused porcine skin flap as in vitro model for predicting transdermal pharmacokinetics. Eur J Pharm Biopharm 1995; 41: 152-62
14. Oberthür C, Hoffmann B, Hamburger M. Synthesis of d-tryptanthrin. Pharmazie, 2002: 586-7
15. Martinez MS, Gutierrez Hurtado B, Colino Gandarillas CI, Martinez Lanao J, Sanchez Navarro A. In vitro study of experimental factors affecting the microdialysis results. Anal Chim Acta 2002; 459: 143-50
16. Benfeldt E, Groth L. Feasibility of measuring lipophilic or protein-bound drugs in the dermis by in vivo microdialysis after topical or systemic drug administration. Acta Derm Venereol 1998; 78: 274-8
17. Friedländer P, Roschdestwensky N. Über ein Oxidationsprodukt des Indigoblaus. Bet dtsch chem Ges 1915; 48: 1841-7