Skin penetration and cellular uptake of amorphous silica nanoparticles with variable size, surface functionalization, and colloidal stability

ACS Nano

Volumn 6, Issue 8, 2012, Pages 6829-6842

  Rancan, Fiorenza ^a   Gao, Qi ^b   Graf, Christina ^b   Troppens, Stefan ^a   Hadam, Sabrina ^a   Hackbarth, Steffen ^c   Kembuan, Cynthia ^b   Blume Peytavi, Ulrike ^a   Rühl, Eckart ^b   Lademann, Jürgen ^a   Vogt, Annika ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

amorphous silica nanoparticles; colloidal stability; dendritic cells; HaCaT cells; keratinocytes; skin penetration

Indexed keywords

AMORPHOUS SILICA; COLLOIDAL STABILITY; DENDRITIC CELLS; KERATINOCYTES; SKIN PENETRATION;

CYTOLOGY; NANOPARTICLES; SILICA; SKIN; TRANSMISSION ELECTRON MICROSCOPY;

CELLS;

NANOPARTICLE; SILICON DIOXIDE;

ARTICLE; CELL LINE; CHEMISTRY; COLLOID; DRUG STABILITY; HUMAN; IN VITRO STUDY; KERATINOCYTE; MATERIALS TESTING; METABOLISM; PHYSIOLOGY; SKIN ABSORPTION; ULTRASTRUCTURE;

CELL LINE; COLLOIDS; DRUG STABILITY; HUMANS; KERATINOCYTES; MATERIALS TESTING; NANOPARTICLES; SILICON DIOXIDE; SKIN ABSORPTION;

EID: 84865613256     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn301622h     Document Type: Article

References (56)

1. Fadeel, B.; Garcia-Bennett, A. E. Better Safe than Sorry: Understanding the Toxicological Properties of Inorganic Nanoparticles Manufactured for Biomedical Applications Adv. Drug Delivery Rev. 2010, 62, 362-374
2. Papakostas, D.; Rancan, F.; Sterry, W.; Blume-Peytavi, U.; Vogt, A. Nanoparticles in Dermatology Arch. Dermatol. Res. 2011, 303, 533-550
3. Xia, T.; Kovochich, M.; Nel, A. The Role of Reactive Oxygen Species and Oxidative Stress in Mediating Particulate Matter Injury Clin. Occup. Environ. Med. 2006, 5, 817-836
4. Shvedova, A. A.; Kagan, V. E.; Fadeel, B. Close Encounters of the Small Kind: Adverse Effects of Man-Made Materials Interfacing with the Nano-cosmos of Biological Systems Annu. Rev. Pharmacol. Toxicol. 2010, 50, 63-88
5. Napierska, D.; Thomassen, L. C. J.; Lison, D.; Martens, J. A.; Hoet, P. H. The Nanosilica Hazard: Another Variable Entity Part. Fibre Toxicol. 2010, 7, 39-71
6. Merad, M.; Ginhoux, F.; Collin, M. Origin, Homeostasis and Function of Langerhans Cells and Other Langerin-Expressing Dendritic Cells Nat. Rev. Immunol. 2008, 8, 935-947
7. Lademann, J.; Weigmann, H. J.; Rickmeyer, C.; Barthelmes, H.; Schaefer, H.; Müller, G.; Sterry, W. Penetration of Titanium Dioxide Microparticles in a Sunscreen Formulation into the Horny Layer and the Follicular Orifice Skin Pharmacol. Appl. Skin Physiol. 1999, 12, 247-256
8. Baroli, B.; Ennas, M. G.; Loffredo, F.; Isola, M.; Pinna, R.; Lopez-Quintela, M. A. Penetration of Metallic Nanoparticles in Human Full-Thickness Skin J. Invest. Dermatol. 2007, 127, 1701-1712
9. Cross, S. E.; Innes, B.; Roberts, M. S.; Tsuzuki, T.; Robertson, T. A.; McCormick, P. Human Skin Penetration of Sunscreen Nanoparticles: In-Vitro Assessment of a Novel Micronized Zinc Oxide Formulation Skin Pharmacol. Physiol. 2007, 20, 148-154
10. Zhang, L. W.; Monteiro-Riviere, N. A. Assessment of Quantum Dot Penetration into Intact, Tape-Stripped, Abraded and Flexed Rat Skin Skin Pharmacol. Phys. 2008, 21, 166-180
11. Larese, F. F.; D'Agostin, F.; Crosera, M.; Adami, G.; Renzi, N.; Bovenzi, M.; Maina, G. Human Skin Penetration of Silver Nanoparticles through Intact and Damaged Skin Toxicology 2009, 255, 33-37
12. Vogt, A.; Combadiere, B.; Hadam, S.; Stieler, K. M.; Lademann, J.; Schaefer, H.; Autran, B.; Sterry, W.; Blume-Peytavi, U. 40 nm, but not 750 or 1,500 nm, Nanoparticles Enter Epidermal CD1a+ Cells after Transcutaneous Application on Human Skin J. Invest. Dermatol. 2006, 126, 1316-1322
13. Mahe, B.; Vogt, A.; Liard, C.; Duffy, D.; Abadie, V.; Bonduelle, O.; Boissonnas, A.; Sterry, W.; Verrier, B.; Blume-Peytavi, U. et al. Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells By Hair Follicles and Their Transport in Mice J. Invest. Dermatol. 2009, 129, 1156-1164
14. Mortensen, L. J.; Oberdorster, G.; Pentland, A. P.; DeLouise, L. A. In Vivo Skin Penetration of Quantum Dot Nanoparticles in the Murine Model: The Effect of UVR Nano Lett. 2008, 8, 2779-2787
15. Rahman, A.; Seth, D.; Mukhopadhyaya, S. K.; Brahmachary, R. L.; Ulrichs, C.; Goswami, A. Surface Functionalized Amorphous Nanosilica and Microsilica with Nanopores as Promising Tools in Biomedicine Naturwissenschaften 2009, 96, 31-38
16. Ketelson, H. A.; Brook, M. A.; Pelton, R. H. Sterically Stabilized Silica Colloids: Radical Grafting of Poly(methyl methacrylate) and Hydrosilylative Grafting of Silicones to Functionalized Silica Polym. Adv. Technol. 1995, 6, 335-344
17. He, X. X.; Wang, K. M.; Tan, W. H.; Li, J.; Yang, X. H.; Huang, S. S.; Li, D.; Xiao, D. Photostable Luminescent Nanoparticles as Biological Label for Cell Recognition of System Lupus Erythematosus Patients J. Nanosci. Nanotechnol. 2002, 2, 317-320
18. Liu, S. H.; Han, M. Y. Synthesis, Functionalization, and Bioconjugation of Monodisperse, Silica-Coated Gold Nanoparticles: Robust Bioprobes Adv. Funct. Mater. 2005, 15, 961-967
19. Calvert, G. M.; Rice, F. L.; Boiano, J. M.; Sheehy, J. W.; Sanderson, W. T. Occupational Silica Exposure and Risk of Various Diseases: An Analysis Using Death Certificates from 27 States of the United States Occup. Environ. Med. 2003, 60, 122-129
20. So, S. J.; Jang, I. S.; Han, C. S. Effect of Micro/Nano Silica Particle Feeding for Mice J. Nanosci. Nanotechnol. 2008, 8, 5367-5371
21. Sayes, C. M.; Reed, K. L.; Warheit, D. B. Assessing Toxicity of Fine and Nanoparticles: Comparing In Vitro Measurements to In Vivo Pulmonary Toxicity Profiles Toxicol. Sci. 2007, 97, 163-180
22. Nabeshi, H.; Yoshikawa, T.; Matsuyama, K.; Nakazato, Y.; Matsuo, K.; Arimori, A.; Isobe, M.; Tochigi, S.; Kondoh, S.; Hirai, T. et al. Systemic Distribution, Nuclear Entry and Cytotoxicity of Amorphous Nanosilica Following Topical Application Biomaterials 2011, 32, 2713-2724
23. Graf, C.; Gao, Q.; Schütz, I.; Noufele, C. N.; Ruan, W.; Posselt, U.; Korotianskiy, E.; Nordmeyer, D.; Rancan, F.; Hadam, S. et al. Surface Functionalization of Silica Nanoparticles Supports Colloidal Stability in Physiological Media and Facilitates Internalization in Cells Langmuir 2012, 28, 7598-7613
24. Okuda-Shimazaki, J.; Takaku, S.; Kanehira, K.; Sonezaki, S.; Taniguchi, A. Effects of Titanium Dioxide Nanoparticle Aggregate Size on Gene Expression Int. J. Mol. Sci. 2010, 11, 2383-2392
25. Stöber, W.; Fink, A.; Bohn, E. Controlled Growth of Monodisperse Silica Spheres in Micron Size Range J. Colloid Interface Sci. 1968, 26, 62-69
26. Bogush, G. H.; Zukoski, C. F. Uniform Silica Particle Precipitation: An Aggregative Growth Model J. Colloid Interface Sci. 1991, 142, 19-34
27. Philipse, A. P. Quantitative Aspects of the Growth of (Charged) Silica Spheres Coll. Pol. Sci. 1988, 266, 1174-1180
28. van Blaaderen, A.; van Geest, J.; Vrij, A. Monodisperse Colloidal Silica Spheres from Tetraalkoxysilanes: Particle Formation and Growth Mechanism J. Colloid Interface Sci. 1992, 154, 481-501
29. Mailänder, V.; Landfester, K. Interaction of Nanoparticles with Cells Biomacromolecules 2009, 10, 2379-2400
30. Kittler, S.; Greulich, C.; Gebauer, J. S.; Diendorf, J.; Treuel, L.; Ruiz, L.; Gonzalez-Calbet, J. M.; Vallet-Regi, M.; Zellner, R.; Koller, M. et al. The Influence of Proteins on the Dispersability and Cell-Biological Activity of Silver Nanoparticles J. Mater. Chem. 2010, 20, 512-518
31. Wiogo, H. T. R.; Lim, M.; Bulmus, V.; Yun, J.; Amal, R. Stabilization of Magnetic Iron Oxide Nanoparticles in Biological Media by Fetal Bovine Serum (FBS) Langmuir 2011, 27, 843-850
32. Verwey, E. J. W.; Overbeek, J. T. G. Theory of the Stability of Lyophobic Colloids; Elsevier: New York, 1948.
33. Derjaguin, B.; Landau, L. Theory of the Stability of Strongly Charged Lyophobic Sols and of the Adhesion of Strongly Charged Particles in Solutions of Electrolytes Acta Physicochim. URSS 1941, 14, 663-667
34. Morrison, I. D. Criterion for Electrostatic Stability of Dispersions at Low Ionic-Strength Langmuir 1991, 7, 1920-1922
35. Holthoff, H.; Egelhaaf, S. U.; Borkovec, M.; Schurtenberger, P.; Sticher, H. Coagulation Rate Measurements of Colloidal Particles by Simultaneous Static and Dynamic Light Scattering Langmuir 1996, 12, 5541-5549
36. Lin, M. Y.; Lindsay, H. M.; Weitz, D. A.; Ball, R. C.; Klein, R.; Meakin, P. Universal Reaction-Limited Colloid Aggregation Phys. Rev. A 1990, 41, 2005-2020
37. Wilhelm, C.; Gazeau, F.; Roger, J.; Pons, J. N.; Bacri, J. C. Interaction of Anionic Superparamagnetic Nanoparticles with Cells: Kinetic Analyses of Membrane Adsorption and Subsequent Internalization Langmuir 2002, 18, 8148-8155
38. Mahtab, F.; Yu, Y.; Lam, J. W. Y.; Liu, J.; Zhang, B.; Lu, P.; Zhang, X.; Tang, B. Z. Fabrication of Silica Nanoparticles with Both Efficient Fluorescence and Strong Magnetization, and Exploration of Their Biological Applications Adv. Funct. Mater. 2011, 21, 1733-1740
39. Kim, S.-I.; Pham, T. T.; Lee, J.-W.; Roh, S.-H. Multi-Amine-Grafted SBA-15 Spherical Nanoparticles for the Adsorption of Proteins J. Nanosci. Nanotechnol. 2010, 10, 3425-3429
40. 2 Submicron Particles Colloid. Surface. B 2010, 75, 432-440
41. Kumar, R.; Roy, I.; Ohulchanskky, T. Y.; Vathy, L. A.; Bergey, E. J.; Sajjad, M.; Prasad, P. N. In Vivo Biodistribution and Clearance Studies Using Multimodal Organically Modified Silica Nanoparticles ACS Nano 2010, 4, 699-708
42. Chen, Z. P.; Xu, R. Z.; Zhang, Y.; Gu, N. Effects of Proteins from Culture Medium on Surface Property of Silanes-Functionalized Magnetic Nanoparticles Nanoscale Res. Lett. 2009, 4, 204-209
43. Asenath-Smith, E.; Chen, W. How To Prevent the Loss of Surface Functionality Derived from Aminosilanes Langmuir 2008, 24, 12405-12409
44. Boukamp, P.; Petrussevska, R. T.; Breitkreutz, D.; Hornung, J.; Markham, A.; Fusenig, N. E. Normal Keratinization in a Spontaneously Immortalized Aneuploid Human Keratinocyte Cell-Line J. Cell Biol. 1988, 106, 761-771
45. Conner, S. D.; Schmid, S. L. Regulated Portals of Entry into the Cell Nature 2003, 422, 37-44
46. Morhenn, V. B.; Lemperle, G.; Gallo, R. L. Phagocytosis of Different Particulate Dermal Filler Substances by Human Macrophages and Skin Cells Dermotol. Surg. 2002, 28, 484-490
47. Kubo, A.; Nagao, K.; Yokouchi, M.; Sasaki, H.; Amagai, M. External Antigen Uptake by Langerhans Cells with Reorganization of Epidermal Tight Junction Barriers J. Exp. Med. 2009, 206, 2937-2946
48. Coombes, J. L.; Robey, E. A. Dynamic Imaging of Host-Pathogen Interactions In Vivo Nat. Rev. Immunol. 2010, 10, 353-364
49. Valladeau, J.; Saeland, S. Cutaneous Dendritic Cells Semin. Immunol. 2005, 17, 273-283
50. Leroueil, P. R.; Hong, S. Y.; Mecke, A.; Baker, J. R.; Orr, B. G.; Banaszak Holl, M. M. Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face? Acc. Chem. Res. 2007, 40, 335-342
51. Rancan, F.; Papakostas, D.; Hadam, S.; Hackbarth, S.; Delair, T.; Primard, C.; Verrier, B.; Sterry, W.; Blume-Peytavi, U.; Vogt, A. Investigation of Polylactic Acid (PLA) Nanoparticles as Drug Delivery Systems for Local Dermatotherapy Pharm. Res. 2009, 26, 2027-2036
52. Lademann, J.; Richter, H.; Teichmann, A.; Otberg, N.; Blume-Peytavi, U.; Luengo, J.; Weiss, B.; Schaefer, U. F.; Lehr, C. M.; Wepf, R. et al. Nanoparticles-An Efficient Carrier for Drug Delivery into the Hair Follicles Eur. J. Pharm. Biopharm. 2007, 66, 159-164
53. Imhof, A.; Megens, M.; Engelberts, J. J.; de Lang, D. T. N.; Sprik, R.; Vos, W. L. Spectroscopy of Fluorescein (FITC) Dyed Colloidal Silica Spheres J. Phys. Chem. B 1999, 103, 1408-1415
54. van Blaaderen, A.; Vrij, A. Synthesis and Characterization of Monodisperse, Colloidal, Organo-Silica Spheres J. Colloid Interface Sci. 1993, 156, 1-18
55. Westcott, S. L.; Oldenburg, S. J.; Lee, T. R.; Halas, N. J. Formation and Adsorption of Clusters of Gold Nanoparticles onto Functionalized Silica Nanoparticle Surfaces Langmuir 1998, 14, 5396-5401
56. Waddell, T. G.; Leyden, D. E.; DeBello, M. T. The Nature of Organosilane to Silica-Surface Bonding J. Am. Chem. Soc. 1981, 103, 5303-5307